Drug-Induced Dyskinesia (Dyskinesia, Drug Induced)

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66 relevant articles (5 outcomes, 5 trials/studies) found for this Disease

Description: Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)

Also Known As:

Dyskinesia, Drug Induced; Dyskinesia, Drug-Induced; Medication-Induced Dyskinesia; Drug-Induced Dyskinesias; Dyskinesia, Medication Induced; Dyskinesias, Drug-Induced; Dyskinesias, Medication-Induced; Medication Induced Dyskinesia; Medication-Induced Dyskinesias; Dyskinesia, Medication-Induced

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3414

Central Nervous System Diseases: 930

Movement Disorders: 1472

Dyskinesias: 5109

Drug-Induced Dyskinesia: 66

Neurotoxicity Syndromes: 127

Drug-Induced Dyskinesia: 66

Disorders of Environmental Origin

Poisoning: 37022

Drug Toxicity: 1290

Drug-Induced Dyskinesia: 66

Neurotoxicity Syndromes: 127

Drug-Induced Dyskinesia: 66

Related Diseases

1.	Parkinsonian Disorders (Parkinsonism)
2.	Dyskinesias (Dyskinesia)
3.	Tremor (Tremors)
4.	Hypokinesia (Bradykinesia)
5.	Psychomotor Agitation (Akathisia)

Experts

1.	Gershanik, O S: 1 article (07/2004)
2.	Taravini, I R E: 1 article (07/2004)
3.	Ferrario, J E: 1 article (07/2004)
4.	Stefano, A V: 1 article (07/2004)
5.	Delfino, M A: 1 article (07/2004)
6.	Murer, M G: 1 article (07/2004)
7.	Manson, A J: 1 article (02/2004)
8.	Katzenschlager, R: 1 article (02/2004)
9.	Lees, A J: 1 article (02/2004)
10.	Evans, A: 1 article (02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Drug-Induced Dyskinesia:

1.	Levodopa (L Dopa)FDA LinkGeneric 04/30/2008 - "Drug induced dyskinesia and end of dose failure were experienced by most patients, but the main current problems relate to the non-levodopa responsive features of the disease" 03/01/2003 - "The reduction in the levodopa dose is useful in controlling drug-induced dyskinesias." 01/01/2003 - "Besides, the MSA patients were more frequently resistant to levodopa and had axial drug-induced dyskinesia (p < 0.05)" 11/01/2001 - "Parkinsonian features included benign course, early onset of drug-induced dyskinesias, and a good and persistent response to levodopa" 03/01/2001 - "After one decade of levodopa therapy, however, drug-induced dyskinesia had become a source of additional disability not amenable to medical treatment" Order ALL the reference details at left...
2.	Dopamine Agents (Dopaminergic Agents)IBA 09/01/2002 - "Electrical stimulation led to a significant improvement in motor symptoms and in the quality of life, allowing a significant reduction of dopaminergic drugs with a consequent improvement of drug-induced dyskinesias" 11/01/2001 - "This study tested for effects on proprioception of dopaminergic drugs, and for associations between such effects and drug induced dyskinesias" 04/01/2000 - "Results suggest that dopaminergic agents act by decreasing GPi and STN activity, and increasing GPe activity, and that drug-induced dyskinesias results from a large reduction in GPi firing." 01/01/2005 - "Dyskinesias are known to occur in many patients with Parkinson's disease treated with dopaminergic drugs but to date, drug-induced dyskinesias have not been observed in humans with no underlying basal ganglia disorder" 09/01/1999 - "The results suggest that memantine may improve parkinsonian symptoms independently of dopaminergic drugs and, in contrast to recent findings with amantadine, it has no effect on drug-induced dyskinesias." Order ALL the reference details at left...
3.	Metoclopramide (Reglan)FDA LinkGeneric 01/01/2003 - "Key search terms included metoclopramide; diabetic gastroparesis; and dyskinesia, drug induced" 06/28/1993 - "Metoclopramide-treated patients had significantly greater severity of tardive dyskinesia, drug-induced parkinsonism, and subjective akathisia than controls" Order ALL the reference details at left...
4.	5-HT2C Serotonin ReceptorIBA 07/01/2005 - "However, pharmacological evidence and recent molecular genetic studies would suggest a role for the 5-HT2C receptor in the consequences of antipsychotic treatment, particularly in relation to the development of both drug-induced dyskinesias and weight gain" Order ALL the reference details at left...
5.	Psychotropic Drugs (Psychoactive Drugs)IBA 07/01/1975 - "Although the term "oral dyskinesia" is used interchangeably with "drug-induced dyskinesia" this author doesn't find sufficient scientific evidence from published studies to implicate the psychotropic drugs solely responsible for "oral dyskinesia." All the previous studies attempting to link drugs etiologically with oral dyskinesia suffered from lack of adequate information and methodological difficulties inherent in the question involved" Order ALL the reference details at left...
6.	diazenedicarboxylic acid bis(N'-methylpiperazide)IBA 09/01/1999 - "Drug-induced dyskinesia and DIP did not show a conspicuous pattern of lateralisation" 09/01/1999 - "This study attempted to contribute to the subtyping of tardive dyskinesia (TD) by studying the effects of age, sex, psychiatric diagnosis and duration of illness on the severity and topographic distribution of dyskinesia, and to describe the topographic distribution of drug-induced dyskinesia (DID) and drug-induced parkinsonism (DIP) in detail by examining 170 consecutive inpatients on antipsychotic treatment" Order ALL the reference details at left...
7.	Bromocriptine (Parlodel)FDA LinkGeneric 01/01/1983 - "Fewer of the late complications associated with levodopa therapy were seen in those taking bromocriptine, and drug-induced dyskinesia was seen in only one patient" 11/01/1981 - "Fewer of the late complications of levodopa therapy occurred in those taking bromocriptine; drug-induced dyskinesia was seen in only one patient and oscillations in performance were not observed" 08/01/1991 - "All remained predominantly responsive to levodopa, although with marked disability secondary to clinical fluctuations (short-duration responses) and medication-induced dyskinesias; all were receiving substantial doses of levodopa and 6 of the 8 patients were additionally receiving bromocriptine or pergolide" Order ALL the reference details at left...
8.	Dopamine Agonists (Dopamine Agonist)IBA 07/09/2004 - "Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias." 02/01/2005 - "Continuous subcutaneous (SC) infusion of the dopamine agonist apomorphine was shown in retrospective studies to improve drug-induced dyskinesias in Parkinson's disease (PD)" Order ALL the reference details at left...
9.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 05/01/1989 - "Drug-induced dyskinesia in primates rendered hemiparkinsonian by intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)." 10/01/1990 - "We examined the ability of L-DOPA to induce dyskinesias in MPTP-treated and normal squirrel monkeys to establish whether the underlying neuropathology associated with parkinsonism is an absolute requirement or merely promotes the development of drug-induced dyskinesias" Order ALL the reference details at left...
10.	Antipsychotic Agents (Antipsychotics)IBA 01/01/2007 - "METHOD: The relevant literature was retrieved via Medline (1960-2005), using combinations of the (mesh) terms 'antipsychotic agents', 'dystonia', 'parkinson disease', 'secondary', 'dyskinesias', 'drug-induced', 'asphyxia' and the key words 'dysphagia' en 'respiratory'" 01/01/1994 - "Similar drug-induced dyskinesias have been described for amphetamine and neuroleptic drugs" Order ALL the reference details at left...

Therapies and Procedures

1.	Microelectrodes 11/01/1998 - "Multiple factors have led to the resurgence of interest in the surgical treatment of PD: 1) recognition that long-term medical therapy for PD is often unsatisfactory, with patients eventually suffering from drug-induced dyskinesias, motor fluctuations, and variable responses to medication; 2) greater understanding of the pathophysiology of PD, providing a better scientific rationale for some previously developed procedures and suggesting new targets; and 3) use of improved techniques, such as computed tomography- and magnetic resonance imaging-guided stereotaxy and single-unit microelectrode recording, making surgical intervention in the basal ganglia more precise" Order ALL the reference details at left...
2.	Pallidotomy 01/01/2001 - "There was a consensus on the benefits of pallidotomy for off period motor function and on period, drug-induced dyskinesias, with variations in the extent of symptomatic benefit across studies" 01/01/2005 - "Nine PD patients, three men and six women, with an average age of 62 years and disease duration of 13 years underwent unilateral globus pallidus internus (GPi) pallidotomy contralateral to the side with marked akinetic symptoms and drug-induced dyskinesia" 10/01/1999 - "Pallidotomy surgery, lesioning the globus pallidus internal, has been performed to alleviate Parkinsonian symptoms and drug-induced dyskinesias" 08/01/2003 - "One lesioning session was enough to relieve tremor in the two patients treated by thalamotomy; three lesioning sessions over a 7-month period were required to relieve drug-induced dyskinesias in the patient treated by pallidotomy" 09/01/1999 - "4) Symptoms that respond best to pallidotomy include medication-induced dyskinesias, rigidity, and tremor, while balance, gait disorders, and hypophonia are generally less responsive to surgery" Order ALL the reference details at left...
3.	Transplants (Transplant) 12/15/2005 - "While there is little doubt that intrastriatal grafts can induce dyskinesias, these appear to differ from common drug-induced dyskinesias" Order ALL the reference details at left...
4.	Neurosurgical Procedures 04/01/2005 - "High-frequency stimulation of the subthalamic nucleus is a neurosurgical procedure for the alleviation of motor symptoms of Parkinson's disease and debilitating medication-induced dyskinesias" Order ALL the reference details at left...
5.	Drug Therapy (Chemotherapy) 12/01/2005 - "Drug-induced dyskinesias (DID) represent a troublesome, dose-limiting, and common complication of long-term pharmacotherapy in Parkinson's disease (PD) patients" Order ALL the reference details at left...

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