|2.||Parkinsonian Disorders (Parkinsonism)
|3.||Amnesia (Dissociative Amnesia)
|4.||Parkinson Disease (Parkinson's Disease)
|1.||Subramanian, Thyagarajan: 5 articles (01/2012 - 12/2005)|
|2.||Lieu, Christopher A: 4 articles (01/2012 - 08/2010)|
|3.||Deogaonkar, Milind: 4 articles (01/2012 - 12/2005)|
|4.||Schwarz, Johannes: 2 articles (01/2014 - 11/2012)|
|5.||Wegner, Florian: 2 articles (01/2014 - 11/2012)|
|6.||Strecker, Karl: 2 articles (01/2014 - 11/2012)|
|7.||Manyam, Bala V: 2 articles (01/2012 - 08/2010)|
|8.||Venkiteswaran, Kala: 2 articles (01/2012 - 08/2010)|
|9.||Kirik, Deniz: 2 articles (07/2010 - 04/2002)|
|10.||Shtok, V N: 2 articles (01/2003 - 04/2002)|
|1.||Levodopa (L Dopa)FDA LinkGeneric
01/01/2015 - "Motor response fluctuations and drug-induced dyskinesias seriously compromise the unparalleled symptomatic efficacy of l-dopa during long-term treatment. "
04/30/2008 - "Drug induced dyskinesia and end of dose failure were experienced by most patients, but the main current problems relate to the non-levodopa responsive features of the disease. "
03/01/2003 - "The reduction in the levodopa dose is useful in controlling drug-induced dyskinesias."
01/01/2003 - "Besides, the MSA patients were more frequently resistant to levodopa and had axial drug-induced dyskinesia (p < 0.05). "
11/01/2001 - "Parkinsonian features included benign course, early onset of drug-induced dyskinesias, and a good and persistent response to levodopa. "
|2.||Dopamine Agents (Dopaminergic Agents)IBA
09/01/2002 - "Electrical stimulation led to a significant improvement in motor symptoms and in the quality of life, allowing a significant reduction of dopaminergic drugs with a consequent improvement of drug-induced dyskinesias. "
11/01/2001 - "This study tested for effects on proprioception of dopaminergic drugs, and for associations between such effects and drug induced dyskinesias. "
04/01/2000 - "Results suggest that dopaminergic agents act by decreasing GPi and STN activity, and increasing GPe activity, and that drug-induced dyskinesias results from a large reduction in GPi firing."
01/01/2005 - "Dyskinesias are known to occur in many patients with Parkinson's disease treated with dopaminergic drugs but to date, drug-induced dyskinesias have not been observed in humans with no underlying basal ganglia disorder. "
02/01/2013 - "Although levodopa and dopaminergic drugs remain the mainstay of therapy for the motor symptoms of Parkinson disease (PD), they fail to address many of the non-motor symptoms of PD including orthostatic hypotension, freezing of gait (FOG) and difficulty with balance, drug-induced paranoia and hallucinations, and drug-induced dyskinesias. "
|3.||Reserpine (Serpasil)FDA Link
|4.||Dopamine (Intropin)FDA LinkGeneric
07/20/2010 - "Drug-induced dyskinesias in dopamine-denervated animals are known to depend on both pre- and postsynaptic changes of the nigrostriatal circuitry. "
07/01/1999 - "It is proposed that striatal dopamine deficiency might play a major role in the pathogenesis of drug-induced dyskinesias. "
12/03/2015 - "Treatment of Parkinson's disease (PD) with dopamine replacement relieves symptoms of poverty of movement, but often causes drug-induced dyskinesias. "
11/01/2012 - "Drug-induced dyskinesia is a major complication of dopamine replacement therapy in advanced Parkinson's disease consisting of dystonia, chorea and athetosis. "
01/04/2012 - "Pharmacological dopamine replacement therapy with medications such as levodopa ameliorates the symptoms of PD but can lead to motor complications known as drug-induced dyskinesias. "
|5.||Amantadine (Aman)FDA LinkGeneric
02/01/2011 - "Amantadine is becoming more commonly used for Parkinson's disease (PD), particularly for its efficacy in treating the drug-induced dyskinesias. "
12/01/2006 - "Amantadine-sulfate has been used for several decades to treat acute influenza A, Parkinson's disease (PD), and acute or chronic drug-induced dyskinesia. "
09/01/1999 - "The results suggest that memantine may improve parkinsonian symptoms independently of dopaminergic drugs and, in contrast to recent findings with amantadine, it has no effect on drug-induced dyskinesias."
|6.||5-HT2C Serotonin ReceptorIBA
|8.||diazenedicarboxylic acid bis(N'-methylpiperazide)IBA
09/01/1999 - "Drug-induced dyskinesia and DIP did not show a conspicuous pattern of lateralisation. "
09/01/1999 - "This study attempted to contribute to the subtyping of tardive dyskinesia (TD) by studying the effects of age, sex, psychiatric diagnosis and duration of illness on the severity and topographic distribution of dyskinesia, and to describe the topographic distribution of drug-induced dyskinesia (DID) and drug-induced parkinsonism (DIP) in detail by examining 170 consecutive inpatients on antipsychotic treatment. "
|9.||1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
05/01/1989 - "Drug-induced dyskinesia in primates rendered hemiparkinsonian by intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)."
01/01/2011 - "The stable 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian (HP) rhesus monkey model of Parkinson's disease (PD) has been frequently used to test preclinical experimental therapeutics targeted to treat patients with advanced PD who suffer from motor fluctuations and drug-induced dyskinesias. "
10/01/1990 - "We examined the ability of L-DOPA to induce dyskinesias in MPTP-treated and normal squirrel monkeys to establish whether the underlying neuropathology associated with parkinsonism is an absolute requirement or merely promotes the development of drug-induced dyskinesias. "
|10.||Antipsychotic Agents (Antipsychotics)IBA
12/01/2009 - "Drug-induced dyskinesias are common side-effects of first-generation antipsychotics (FGAs) but are not usually related to second-generation antipsychotics (SGAs). "
01/01/2007 - "The relevant literature was retrieved via Medline (1960-2005), using combinations of the (mesh) terms 'antipsychotic agents', 'dystonia', 'parkinson disease', 'secondary', 'dyskinesias', 'drug-induced', 'asphyxia' and the key words 'dysphagia' en 'respiratory'. "
01/01/1994 - "Similar drug-induced dyskinesias have been described for amphetamine and neuroleptic drugs. "
|1.||Deep Brain Stimulation
11/01/1998 - "Multiple factors have led to the resurgence of interest in the surgical treatment of PD: 1) recognition that long-term medical therapy for PD is often unsatisfactory, with patients eventually suffering from drug-induced dyskinesias, motor fluctuations, and variable responses to medication; 2) greater understanding of the pathophysiology of PD, providing a better scientific rationale for some previously developed procedures and suggesting new targets; and 3) use of improved techniques, such as computed tomography- and magnetic resonance imaging-guided stereotaxy and single-unit microelectrode recording, making surgical intervention in the basal ganglia more precise. "
01/01/2001 - "There was a consensus on the benefits of pallidotomy for off period motor function and on period, drug-induced dyskinesias, with variations in the extent of symptomatic benefit across studies. "
01/01/2005 - "Nine PD patients, three men and six women, with an average age of 62 years and disease duration of 13 years underwent unilateral globus pallidus internus (GPi) pallidotomy contralateral to the side with marked akinetic symptoms and drug-induced dyskinesia. "
10/01/1999 - "Pallidotomy surgery, lesioning the globus pallidus internal, has been performed to alleviate Parkinsonian symptoms and drug-induced dyskinesias. "
08/01/2003 - "One lesioning session was enough to relieve tremor in the two patients treated by thalamotomy; three lesioning sessions over a 7-month period were required to relieve drug-induced dyskinesias in the patient treated by pallidotomy. "
09/01/1999 - "(4) Symptoms that respond best to pallidotomy include medication-induced dyskinesias, rigidity, and tremor, while balance, gait disorders, and hypophonia are generally less responsive to surgery. "