Dysgammaglobulinemia

02/01/1987 - "From these conclusions the etiology of the dysgammaglobulinemia in UM-B19 chickens is hypothesized to be primarily due to delayed bursal development: Immature BG cells are eliminated by environmental antigens during the neonatal period in a process similar to tolerance induction. "
11/01/1981 - "The immunodeficiency was characterized by low T-cell numbers and function, very low levels of thymic hormone, dysgammaglobulinemia, and an inability to mount a primary antibody or cell-mediated response to new antigens. "
03/24/1988 - "Fatal T-cell lymphomas developed in three patients with a chronic illness manifested by fever, pneumonia, dysgammaglobulinemia, hematologic abnormalities, and extraordinarily high titers of antibody to the Epstein-Barr virus (EBV) capsid antigen (greater than 10,000) and early antigen (greater than 640) but low titers to the EBV nuclear antigen (less than or equal to 40). "
09/01/2021 - "Iatrogenic or secondary dysgammaglobulinemia is a main consequence of targeted therapies using monoclonal antibodies and other antibody-derived treatments that target specific antigens on lymphoid cells (blinatumomab, inotuzumab ozogamicin, rituximab), chimeric antigen receptor T cells, tyrosine kinase inhibitors (imatinib, dasatinib, nilotinib) and, to a lesser extent, checkpoint inhibitors (pembrolizumab, nivolumab). "

04/01/2010 - "At least some TS/OCD patients may suffer IgA dysgammaglobulinemia, possibly rendering the children more prone to URTI."
01/01/2005 - "However, dysgammaglobulinemia related to mucosal immunoglobulin A, can be considered as alteration associated with mucosal problems."
10/01/1985 - "[Dysgammaglobulinemia with a reduced IgA in pneumology]."
01/01/2019 - "Immunoglobulin A Dysgammaglobulinemia Is Associated with Pediatric-Onset Obsessive-Compulsive Disorder."
04/01/2010 - "Children with Tourette's syndrome may suffer immunoglobulin A dysgammaglobulinemia: preliminary report."

07/01/1985 - "To study the role of bursal development on the expression of dysgammaglobulinemia in these birds, we examined the effect of bursacyte transfer to line 140 birds and parabiosis between UCD 140 and a control line of chickens on changes in serum IgM and 7S Ig levels. "
03/01/2016 - "Selective immunoglobulin M (SIgM) deficiency is a rare form of dysgammaglobulinemia. "
01/01/2009 - "IgM deficiency is a dysgammaglobulinemia characterized by isolated low levels of serum IgM. "
01/01/1992 - "Furthermore, the same type of dysgammaglobulinemia with increased IgM was found in the patient's father and brother. "
11/30/1977 - "[Type V dysgammaglobulinemia (IgM deficiency)]."

04/15/1986 - "Lymphocyte blastogenic responses were decreased and there was dysgammaglobulinemia in pups in which quantitative studies of immunoglobulins were made. "
02/01/1987 - "Attempts to localize the defect in dysgammaglobulinemia of UM-B19 chickens by studying the effect of immunomodulating substances on immunoglobulin and antibody production."
09/01/1980 - "Inherited 7 S immunoglobulin deficiency in chickens: late onset dysgammaglobulinemia and evaluation of the lymphocyte proliferative responses and other immunologic functions."
04/15/1979 - "[Partial deficiency of immunoglobulins (dysgammaglobulinemia). "
11/01/1977 - "The III type of dysgammaglobulinemia was found to be characteristic of patients with microangiopathies; changes in the immunoglobulin content were directly opposite to the changes revealed in patients with microangiopathies. "

01/01/1968 - "Study of an 11-year-old girl with recurrent severe infections associated with dysgammaglobulinemia, lymphopenia and lymphocytotoxic antibody, resulting in loss of immunologic memory."

01/01/1978 - "[Effect of IgG dysgammaglobulinemia on the process of adaption of premature infant]."
01/01/1979 - "[Primary gastric plasmacytoma with IgG dysgammaglobulinemia and macrocytic anemia (author's transl)]."
11/22/2002 - "Mice lacking both IL-4 and IL-21R exhibited a significantly more pronounced phenotype, with dysgammaglobulinemia, characterized primarily by a severely impaired IgG response. "
02/01/1987 - "Beside the appearance of high levels of IgG in dysgammaglobulinemic chickens during the first weeks of life and in transitory dysgammaglobulinemia, remarkable IgG synthesis can be temporarily induced by the mitogenic activity of LPS and even more by the regulatory function of Levamisole. "
03/31/1967 - "[Dysgammaglobulinemia with hyper-immunoglobulin A (paradoxal immunoglobulin A-immunoglobulin G)]."

07/01/1990 - "Murine GVHD can serve as a model for studying dysgammaglobulinemias in general and for hyper-IgE formation in particular."
01/01/2021 - "DOCK8-deficient patients present early in life with eczema, viral cutaneous infections, chronic mucocutaneous candidiasis, bacterial pneumonia, and abscesses, together with eosinophilia, thrombocytosis, lymphopenia, and variable dysgammaglobulinemia that usually includes Hyper-IgE. "
07/01/1988 - "In contrast, NK cells from patients with various dysgammaglobulinemias could not be induced to express FcER or FcAR corresponding to their abnormal circulating IgE and/or IgA levels. "
01/01/1984 - "Lack of IgG in a healthy adult: a rare case of dysgammaglobulinemia with undetectable serum IgG, IgA2, and IgE."

12/01/2010 - "No systemic manifestations of Castleman syndrome, such as iron-refractory hypochromic/microcytic anemia and dysgammaglobulinemia, were found. "
07/15/1988 - "The patients preoperatively manifested iron-resistant hypochromic microcytic anemia, and one of them had dysgammaglobulinemia and stunted growth. "
09/01/2005 - "This tumor is often seen in children, but not in adults, with a systemic inflammatory syndrome (iron-resistant microcytic anemia and/or dysgammaglobulinemia) and very rarely with a persistent moderate hyperthermia. "

01/01/2004 - "It is suggested that comparison of the gamma-globulin levels by the different methods is a simple and useful method of detecting these dysgammaglobulinemias."
08/01/1964 - "DYSGAMMAGLOBULINEMIA: REPORT OF A CASE WITH A FAMILY HISTORY OF A CONGENITAL GAMMA GLOBULIN DISORDER."
06/01/1962 - "The two patients with dysgammaglobulinemia had high serum concentrations of the 19S gamma(1)-globulins and a marked deficit of the 7S gamma-globulins. "
06/01/1962 - "The site of synthesis of the 19S gamma-globulins in dysgammaglobulinemia."

03/01/1989 - "Inability of oral bovine transfer factor to eradicate cryptosporidial infection in a patient with congenital dysgammaglobulinemia."
01/01/1975 - "Diseases in which transfer factor appeared to cause improvement include the Wiskott-Aldrich syndrome, severe combined immunodeficiency disease, mucocutaneous candidiasis, chronic active hepatitis, coccidioidmycosis, dysgammaglobulinemia, Behcet disease, aphthous stomatitis, linear morphea, familial keratoacanthoma and malignancy."
03/01/1989 - "A 31-year-old man with dysgammaglobulinemia Type I (deficient IgG, IgA, and elevated IgM) and persistent cryptosporidiosis was treated over a 13-week period with oral bovine transfer factor from calves immunized with cryptosporidia. "

01/01/2021 - "We conducted a prospective study in children and young adults with acute lymphoblastic leukaemia treated with CART19, analysing the kinetics of BCA and dysgammaglobulinemia during therapy, as well as the B-cell reconstitution in those with CART19 loss. "
01/01/2021 - "CD19-CAR T-cell therapy (CART19) causes B-cell aplasia (BCA) and dysgammaglobulinemia but there is a lack of information about the degree of its secondary immunodeficiency. "
04/18/1998 - "The dysgammaglobulinemia persisted after therapy. "
01/01/1999 - "We report a child with antibody deficiency (dysgammaglobulinemia) and disseminated MAI infection, in whom complete, long-term remission was attained with multiple antimycobacterial therapy. "
09/01/2021 - "Secondary Dysgammaglobulinemia in Children with Hematological Malignancies Treated with Targeted Therapies."

01/01/2020 - "Of the 14 patients eligible for persistent dysgammaglobulinemia analysis (3 had received RTX retreatment, 2 had <12 months post-RTX follow-up, and in 1 data for this time point was missing), 2/14 (14%) remained with complete B-cell depletion, and 5/14 (36%) had dysgammaglobulinemia. "

07/01/2013 - "In this report we present a patient with refractory chronic diarrhea, recurrent pneumonia, and dysgammaglobulinemia after thymectomy, who was finally then diagnosed with Good syndrome. "

07/01/1973 - "Conventional Swiss mice were treated from birth with intraperitoneal injections of anti-immunoglobulins in an attempt to create an experimental dysgammaglobulinemia. "