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Bacillary Dysentery (Shigellosis)

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DYSENTERY caused by gram-negative rod-shaped enteric bacteria (ENTEROBACTERIACEAE), most often by the genus SHIGELLA. Shigella dysentery, Shigellosis, is classified into subgroups according to syndrome severity and the infectious species. Group A: SHIGELLA DYSENTERIAE (severest); Group B: SHIGELLA FLEXNERI; Group C: SHIGELLA BOYDII; and Group D: SHIGELLA SONNEI (mildest).

Also Known As:

Shigellosis; Dysentery, Shigella; Dysentery, Bacillary; Dysentery, Shiga bacillus; Dysentery, Shigella boydii; Dysentery, Shigella dysenteriae; Dysentery, Shigella dysenteriae type 1; Dysentery, Shigella flexneri; Dysentery, Shigella sonnei; Shigella Dysentery; Dysenteries, Shigella; Dysenteries, Shigella boydii; Dysenteries, Shigella dysenteriae; Dysenteries, Shigella flexneri; Dysenteries, Shigella sonnei; Shiga bacillus Dysentery; Shigella Dysenteries; Shigella boydii Dysenteries; Shigella boydii Dysentery; Shigella dysenteriae Dysenteries; Shigella dysenteriae Dysentery; Shigella flexneri Dysenteries; Shigella flexneri Dysentery; Shigella sonnei Dysenteries; Shigella sonnei Dysentery; boydii Dysenteries, Shigella; boydii Dysentery, Shigella; dysenteriae Dysenteries, Shigella; dysenteriae Dysentery, Shigella; flexneri Dysenteries, Shigella; flexneri Dysentery, Shigella; sonnei Dysenteries, Shigella; sonnei Dysentery, Shigella

Networked: 625 relevant articles (60 outcomes, 69 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Salmonella Infections (Salmonellosis)
2.	Typhoid Fever (Typhoid)
3.	Infection
4.	Cholera
5.	Enteritis

Experts

1.	Sansonetti, Philippe J: 9 articles (02/2009 - 05/2002)
2.	Raqib, Rubhana: 6 articles (11/2006 - 06/2002)
3.	Andersson, Jan: 5 articles (06/2006 - 06/2002)
4.	Raqib, R: 4 articles (01/2010 - 06/2000)
5.	Diederich, François: 4 articles (12/2009 - 06/2008)
6.	Nair, G B: 4 articles (06/2007 - 06/2001)
7.	von Seidlein, Lorenz: 4 articles (09/2006 - 01/2005)
8.	Lee, Hyejon: 4 articles (09/2006 - 01/2005)
9.	Ali, Mohammad: 4 articles (09/2006 - 01/2005)
10.	Clemens, John D: 4 articles (07/2006 - 09/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bacillary Dysentery:

1.	Nalidixic Acid FDA Link 11/01/2004 - "As a consequence, should antimicrobial therapy be indicated, the efficacy of nalidixic acid as the preferred treatment for children with bacillary dysentery has been jeopardised." 11/01/1988 - "I. Randomized, double-blind trial of nalidixic acid in childhood shigellosis." 08/01/2009 - "Nalidixic acid has been one of the most common agents used for the treatment of shigellosis. " 12/01/2002 - "Reported here is a retrospective molecular analysis of the isolates recovered from the first outbreak of nalidixic acid (NA)-resistant Shigella sonnei shigellosis to occur in Israel. " 12/01/2002 - "Retrospective analysis of the first clonal outbreak of nalidixic acid-resistant Shigella sonnei shigellosis in Israel." Order ALL the reference details at left...
2.	Ampicillin (Omnipen)FDA LinkGeneric 02/01/1981 - "Thus, in highly endemic areas SD ampicillin is clinically effective therapy for ampicillin-sensitive shigellosis in patients older than four years of age." 02/01/1981 - "To evaluate a more economical regimen for severe shigella dysentery, treatment with single-dose (SD) ampicillin (100 mg/kg) was compared in a randomized trial with results obtained in a conventional five-day (100 mg/kg per 24 hr) multiple-dose (MD) course. " 01/01/2006 - "However, to avoid the loss of this choice, ampicillin which still has an high effectivity rate, should be preferred for the treatment of shigellosis with the guidence of antibiogram results. " 06/01/1990 - "Ampicillin is still the most frequently used drug for most forms of shigellosis in the Philippines. " 02/01/1981 - "Single-dose ampicillin therapy for severe shigellosis in Bangladesh." Order ALL the reference details at left...
3.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)FDA LinkGeneric 01/01/1998 - "These results demonstrate that trimethoprim-sulfamethoxazole should not be used in the treatment of shigellosis." 03/01/1982 - "Oral or intravenous trimethoprim-sulfamethoxazole therapy for shigellosis." 04/01/1979 - "Three-day treatment of shigellosis with co-trimoxazole." 04/27/1987 - "Trimethoprim/sulfamethoxazole is currently considered the treatment of choice for shigellosis and severe travelers' diarrhea. " 06/01/2007 - "Oral trimethoprim/sulfamethoxazole (TMP-SMX) is approved by the US Food and Drug Administration for the treatment of urinary tract infections, shigellosis, acute otitis media in pediatric patients, and Pneumocystis carinii pneumonia. " Order ALL the reference details at left...
4.	Furazolidone (Furoxone)FDA Link 01/01/1972 - "Failure of furazolidone therapy in shigellosis." 09/01/1968 - "Furazolidone in the treatment of institutional shigellosis." 01/01/1960 - "The evaluation of furazolidone in the treatment of shigellosis." 04/01/1959 - "A bacillary dysentery outbreak at a large university: final control with furazolidone (furoxone)." 07/01/1972 - "Clinical evaluation of co-trimoxazole and furazolidone in treatment of shigellosis in children." Order ALL the reference details at left...
5.	Anti-Bacterial Agents (Antibiotics)IBA 12/01/2005 - "Monitoring of antimicrobial susceptibility through a surveillance programme is recommended to select appropriate antibiotics for the effective treatment of shigellosis in this region." 01/01/2010 - "More trials adhering to standard guidelines are required to evaluate the role of antibiotics in the treatment of severe forms of Shigella dysentery and in groups who are at high risk of complications." 01/01/2010 - "SELECTION CRITERIA: Randomized controlled trials of antibiotics for Shigella dysentery. " 01/01/2009 - "More trials adhering to standard guidelines are required to evaluate the role of antibiotics in the treatment of severe forms of Shigella dysentery and in groups who are at high risk of complications." 01/01/2009 - "SELECTION CRITERIA: Randomized controlled trials of antibiotics for Shigella dysentery. " Order ALL the reference details at left...
6.	VaccinesIBA 02/01/1996 - "Because it is relatively inexpensive and convenient, this model should facilitate study of the pathophysiology and immunology of shigellosis, thereby speeding development of oral vaccines, which can be tested in this animal model." 01/01/1985 - "Two attenuated strains are presently being tested in volunteer studies as candidate vaccines against shigellosis; one uses S. " 11/01/1984 - "Two attenuated strains are presently being tested in volunteer studies as candidate vaccines against shigellosis; one uses S. " 03/01/1984 - "Two attenuated strains are presently being tested in volunteer studies as candidate vaccines against shigellosis; one uses S. " 12/01/2009 - "Vaccines to prevent shigellosis can be divided into living and nonliving approaches. " Order ALL the reference details at left...
7.	QuinolonesIBA 01/01/1988 - "Although further clinical trials are necessary to assess the comparative efficacy of the quinolones, the present clinical data already indicate that they will be of great utility, and particularly important in the treatment of drug-resistant shigellosis, which is currently a major problem in many developing nations in Asia and Africa." 01/01/1999 - "A number of randomised controlled trials of the quinolones in shigellosis have demonstrated their efficacy and safety in children. " 07/01/1995 - "Controlled studies have shown that quinolones, administered in varying regimens ranging from a single dose to 5 days treatment, significantly reduce the intensity and severity of travellers' diarrhoea as well as shigellosis. " 01/06/1998 - "Quinolones are widely employed to treat shigellosis. " 11/01/1994 - "Thus, quinolones may be an effective alternative therapy for travel-related shigellosis." Order ALL the reference details at left...
8.	Trimethoprim (Proloprim)FDA LinkGeneric 11/01/1987 - "Although we were unable to demonstrate a difference in efficacy between the two dosage schedules of trimethoprim, we conclude that both treatment regimens are effective for the treatment of Shigella dysentery." 11/01/1987 - "Fifty-three adults hospitalized with Shigella dysentery were empirically treated with trimethoprim (200 mg) twice/day for 5 days, a single dose of trimethoprim (600 mg), or placebo in a randomized double-blind trial. " 01/01/1985 - "Before recommending trimethoprim as standard therapy for shigellosis, the validity of our results should be tested in a larger trial and the long-term ecological consequences of monotherapy carefully monitored." 11/01/1987 - "Empirical treatment of Shigella dysentery with trimethoprim: five-day course vs. single dose." 01/01/1985 - "Treatment of severe bacillary dysentery with trimethoprim alone." Order ALL the reference details at left...
9.	Cefixime (Suprax)FDA Link 01/01/1999 - "Cefixime showed some promise in treating shigellosis in an open labeled trial. " 06/01/2000 - "Treatment of shigellosis with cefixime: two days vs. five days." 04/01/1998 - "Cefixime should be considered as an alternative drug of choice for shigellosis in children." 10/01/1995 - "CONCLUSION: Cefixime is ineffective in treating shigellosis in adults when used in the standard recommended dosage." 10/01/1995 - "Treatment of shigellosis: IV. Cefixime is ineffective in shigellosis in adults." Order ALL the reference details at left...
10.	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 11/01/1993 - "Comparative efficacy of two- and five-day courses of ceftriaxone for treatment of severe shigellosis in children." 11/01/1993 - "Our study, involving 40 children, demonstrated that a 2-day course of ceftriaxone was as beneficial as a 5-day course and constituted effective therapy for children with severe shigellosis." 01/01/2009 - "Emergence of resistance to ceftriaxone in Shigella may have grave implications in treatment of severe shigellosis in very young patients." 11/01/1993 - "Administration of ceftriaxone for 5 days has been shown to be highly efficient in the treatment of severe shigellosis in children. " 04/01/1991 - "Comparative efficacy of ceftriaxone and ampicillin for treatment of severe shigellosis in children." Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/30/1998 - "Beta-lactam resistance poses a major problem in the chemotherapy of shigellosis caused by Shigella dysenteriae. " 09/01/1985 - "Which chemotherapy for shigella dysentery?" 02/01/1963 - "Shigellosis: mass drug therapy in an institutional setting." 01/01/1955 - "[Chemotherapy of bacillary dysentery.]" 01/01/1947 - "[Disulfan and sulgin in chemotherapy of acute bacillary dysentery.]" Order ALL the reference details at left...
2.	Fluid Therapy (Oral Rehydration Therapy) 10/01/2004 - "The mainstay of treatment of shigellosis in children is correction of the fluid and electrolyte loss, which often is achieved by the administration of oral rehydration solutions. " 01/01/1993 - "This association has not been described in children and should be considered in children with shigellosis who do not respond to rehydration therapies." 03/19/1983 - "Intestinal fluid loss in Shigella dysentery: role of oral rehydration therapy." 11/01/2004 - "Treatment includes use of an effective antibiotic, rehydration therapy (if there is dehydration) and appropriate feeding during and after an episode of shigellosis. " 07/01/1996 - "Rehydration therapy is the key to the management of acute watery diarrhoea, whereas antibiotics play a vital role in the management of acute invasive diarrhoea, particularly shigellosis. " Order ALL the reference details at left...
3.	Day Care (Partial Hospitalization) 06/01/1995 - "The study's objectives were to assess (1) control of a community outbreak of shigellosis through the promotion of handwashing, (2) risk factors in day-care centers, and (3) shigellosis attributable to attendance at a day-care center. " 06/01/1986 - "Control of day care shigellosis: a trial of convalescent day care in isolation." 10/06/2006 - "This report describes the investigation of two outbreaks of MDR shigellosis associated with day care centers and reviews measures for prevention and control of S. " 06/01/1995 - "A case-control study compared day-care centers that had confirmed cases of shigellosis with centers that had none. " 06/01/1995 - "Annotation: a community-focused strategy for the control of day-care center shigellosis." Order ALL the reference details at left...
4.	Intensive Care (Surgical Intensive Care) 02/01/2005 - "A rare case of neonatal shigellosis caused by Shigella boydii in a preterm neonate, severe enough to necessitate intensive care support, is presented. " Order ALL the reference details at left...
5.	Cardiopulmonary Resuscitation (CPR) 01/25/1980 - "Shigellosis from cardiopulmonary resuscitation." Order ALL the reference details at left...

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