|1.||Omran, Heymut: 13 articles (10/2015 - 09/2004)|
|2.||Olbrich, Heike: 12 articles (10/2015 - 09/2004)|
|3.||Chung, Eddie M K: 9 articles (09/2014 - 08/2002)|
|4.||Mitchison, Hannah M: 9 articles (09/2014 - 08/2002)|
|5.||Hafezparast, Majid: 8 articles (02/2015 - 09/2003)|
|6.||Schmidts, Miriam: 8 articles (01/2014 - 12/2009)|
|7.||Holzbaur, Erika L F: 8 articles (08/2013 - 05/2002)|
|8.||Loges, Niki T: 7 articles (10/2015 - 04/2012)|
|9.||Dupuis, Luc: 7 articles (04/2015 - 01/2009)|
|10.||Knowles, Michael R: 7 articles (08/2014 - 07/2005)|
|1.||Motor Neuron Disease (Primary Lateral Sclerosis)
09/01/2007 - "Paradoxically, evidence from studies on the legs at odd angles (Loa) mouse and a transgenic mouse model for human motor neuron disease suggest that partial limitation of the function of dynein may in fact lead to improved axonal transport in the transgenic mouse, leading to delayed disease onset and increased life span."
06/11/2010 - "The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease."
08/20/2007 - "These findings are consistent with studies indicating that perturbations in dynein activity can contribute to the aberrant accumulations of neurofilaments that accompany ALS/motor neuron disease."
06/01/2011 - "Mice with mutation in dynein heavy chain 1 do not share the same tau expression pattern with mice with SOD1-related motor neuron disease."
01/01/2009 - "Altogether, these findings show that dynein heavy chain mutation triggers sensory neuropathy rather than motor neuron disease."
|2.||Kartagener Syndrome (Primary Ciliary Dyskinesia)
03/01/2000 - "The gold standard for the diagnosis of primary ciliary dyskinesia (PCD) is a dynein deficiency shown with transmission electron microscopy. "
06/01/1998 - "The results of this study show that patients with Kartagener's syndrome may have normal ciliary ultrastructure and the absence of dynein arms is not necessarily associated with ciliary immotility. "
04/01/1994 - "Ciliary motion analysis demonstrated a total absence of ciliary motion whereas, ultrastructural studies revealed typical features of primary ciliary dyskinesia (PCD) (absence or short outer/inner dynein arms in 90% of the cilia). "
01/01/1990 - "No abnormal ciliary ultrastructures specific to Kartagener's syndrome, such as absence of dynein arms, were detected in this study. "
10/01/2015 - "Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex."
|3.||Huntington Disease (Huntington's Disease)
01/01/2012 - "First, we confirmed the post-translational myristoylation of two previously identified putative substrates, cytoplasmic dynein intermediate chain 2A and PKCε (ctPKCε), and identified 5 more caspase-cleaved potential substrates for myristoylation that include the antiapoptotic regulator of apoptosis, Mcl-1, and the causative agent of Huntington's disease, huntingtin protein. "
01/01/2011 - "The molecular motor dynein is regulated by the huntingtin protein, and Huntington's disease (HD) mutations of huntingtin disrupt dynein motor activity. "
01/01/2011 - "Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues."
07/01/2005 - "We show that mutations of the dynein machinery enhanced the toxicity of the mutation that causes Huntington disease in fly and mouse models. "
10/01/2005 - "These studies highlight the importance of dyneins and autophagy in the clearance of aggregate-prone proteins in general, and also in the specific case of Huntington's disease. "
04/03/2012 - "Using an improved application of an optical trap, we were now able to demonstrate that cytoplasmic dynein can generate a discrete power stroke as well as a processive walk in either direction; i.e., towards the plus- or towards the minus-end of a microtubule. "
05/20/2014 - "In flagella, dynein e likely acts as a facilitator by holding adjacent microtubules to aid dynein c's power stroke."
05/01/2014 - "Our results reveal that the rotation of the head relative to the linker is the key action in dynein movement, and that there are at least two distinct pre-power-stroke conformations: pre-I (microtubule-detached) and pre-II (microtubule-bound). "
05/01/2014 - "Here, using cryo-electron tomography of intact, active (that is, beating), rapidly frozen sea urchin sperm flagella, we determined the in situ three-dimensional structures of all domains of both pre- and post-power-stroke dynein, including the previously unresolved linker and stalk of pre-power-stroke dynein. "
05/01/2014 - "Structural mechanism of the dynein power stroke."
01/01/2014 - "Altogether, our study revealed that MPyV cytoplasmic trafficking leading to productive infection bypasses recycling endosomes, does not require the function of kinesin-1 and kinesin-2, but depends on functional dynein-mediated transport along microtubules for translocation of the virions from peripheral, often caveolin-positive compartments to late endosomes and ER - a prerequisite for efficient delivery of the viral genome to the nucleus. "
07/01/2005 - "The precise role of the rabies virus P-dynein interaction in the axonal transport of rabies virus, particularly the importance of this interaction during natural infection, merits further study."
12/01/2014 - "Rabies virus retrograde axonal transport by dynein motors supports virus spread over long distances and lethal infection of the central nervous system. "
08/01/2014 - "These results suggested that cytoplasmic dynein was involved in WSSV infection."
08/01/2014 - "Cloning and characterization of cytoplasmic dynein intermediate chain in Fenneropenaeus chinensis and its essential role in white spot syndrome virus infection."
|1.||Proteins (Proteins, Gene)
|3.||Adenosine Triphosphatases (ATPase)
|4.||NF-kappa B (NF-kB)
|6.||DNA (Deoxyribonucleic Acid)
|8.||Casein Kinase II (Casein Kinase 2)
|9.||I-kappa B Proteins (I kappa B)
|10.||tax Gene Products (tax Gene Product)
|2.||Surgical Instruments (Clip)