Dupuytren Contracture (Dupuytrens Contracture)

A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. It arises most commonly in men between the ages of 30 and 50.

Also Known As:

Networked: 1021 relevant articles (72 outcomes, 165 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Contracture
2.	Pain (Aches)
3.	Rupture
4.	Disease Progression
5.	Wounds and Injuries (Trauma)

Experts

1.	Gan, Bing Siang: 14 articles (08/2014 - 06/2003)
2.	Werker, Paul M N: 13 articles (04/2021 - 05/2006)
3.	Selles, Ruud W: 12 articles (01/2022 - 07/2015)
4.	Bayat, Ardeshir: 11 articles (01/2014 - 06/2003)
5.	Satish, Latha: 10 articles (02/2022 - 04/2008)
6.	O'Gorman, David B: 10 articles (01/2021 - 08/2006)
7.	Hovius, Steven E R: 10 articles (03/2020 - 11/2014)
8.	Hentz, Vincent R: 10 articles (06/2014 - 09/2002)
9.	Degreef, Ilse: 9 articles (04/2022 - 01/2009)
10.	Hurst, Lawrence C: 8 articles (12/2021 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dupuytren Contracture:

1.	Microbial Collagenase (Clostridiopeptidase A)FDA Link 12/01/2010 - "Collagenase clostridium histolyticum is the first Food and Drug Administration-approved, nonsurgical treatment option for adult Dupuytren's contracture patients with a palpable cord that is highly effective and well tolerated. " 04/01/2017 - "Collagenase clostridium histolyticum (CCH) has proven to be both safe and effective in the treatment of Dupuytren disease (DD). " 03/01/2016 - "Collagenase Clostridium histolyticum is a good treatment option for pretendinous cords in thumbs affected with Dupuytren disease because it provides good results, is minimally invasive, and has minor adverse events. " 11/01/2022 - "Underdosing collagenase clostridium histolyticum is equally effective in the treatment of Dupuytren's disease." 05/01/2017 - "Treatment of Recurrent Dupuytren Contracture in Joints Previously Effectively Treated With Collagenase Clostridium histolyticum."
2.	Collagenases (Collagenase)FDA Link 01/01/2019 - "We present a case of a 61-year-old right hand-dominant male with a 2-year history of isolated right small finger Dupuytren's contracture at the DIP joint who achieved significant improvement after collagenase injection." 09/01/2013 - "The use of collagenase injection in the treatment of palmar form of Dupuytren's disease gives good results in the short and medium terms. " 02/01/2022 - "Conclusions: Collagenase is effective in the treatment of Dupuytren contracture, with disease involving the little finger showing the greatest benefit. " 12/01/2014 - "The use of collagenase appears to be an effective and safe method for the treatment of Dupuytren's contracture. " 10/01/2017 - "Collagenase injection is a safe and effective treatment option for Dupuytren disease, but recurrence is common especially for the PIP joint."
3.	CollagenIBA 01/01/2022 - "Finally, spectroscopic assays revealed a significant reduction of the collagen content and alterations of collagen cross-linking within the Dupuytren's disease tissues. " 08/01/1991 - "The objective of this study was to determine if fibroblasts from patients with Dupuytren's contracture have an intrinsic aberration in collagen production or whether local factors govern the collagen changes in Dupuytren's contracture. " 01/01/1990 - "The search for the causative factors in Dupuytren's disease has historically progressed form gross anatomical dissection, through microscopical tissue studies, to the biochemistry of the collagen produced. " 04/01/1984 - "Biochemical studies on the collagen of the palmar aponeurosis affected with Dupuytren's disease." 06/01/1981 - "No alterations of the molecular structure or the state of macromolecular aggregation of the collagen in Dupuytren's disease were detected by wide or low-angle x-ray diffraction studies or by transmission electron microscopy. "
4.	SolutionsIBA 01/01/2020 - "We found that our CHC solution is safe and effective when simultaneously treating as many as four joints affected by Dupuytren's disease. " 01/01/1986 - "While helpful in the early care of these patients, the open palm method does not modify the long-term results in Dupuytren's disease, which is a pervasive condition without simple surgical solution." 07/01/1996 - "Microvascular solution for vascular complication in surgery for Dupuytren's contracture: a case report." 07/30/1959 - "[Cutaneous hydrocortisone solution in Dupuytren's contracture]."
5.	Adalimumab (Humira)FDA Link 07/01/2018 - "These data form the basis of an ongoing phase 2b clinical trial assessing the efficacy of intranodular injection of 40 mg adalimumab in 0.4 ml compared to an equivalent volume of placebo in patients with early stage Dupuytren's disease. " 11/01/2022 - "To estimate the potential cost-effectiveness of adalimumab compared with standard care alone for the treatment of early-stage Dupuytren's disease (DD) and the value of further research from an NHS perspective. " 11/01/2022 - "Cost-effectiveness of adalimumab for early-stage Dupuytren's disease : an economic evaluation based on a randomized controlled trial and individual-patient simulation model." 06/01/2022 - "In this phase 2b, randomised, double-blind, placebo-controlled trial adults with early-stage Dupuytren's disease and an established clinically distinct nodule with a clear history of progression in the preceding 6 months were recruited from two clinical centres in the UK and were randomly assigned 1:1 to receive four injections of adalimumab or saline every 3 months. " 01/01/2018 - "The objective of this paper is to describe the methods applied to assess the cost-effectiveness of adalimumab injections compared to usual care for controlling the progression of early stage DD in the Repurposing Anti-TNF for Treating Dupuytren's Disease (RIDD) trial. "
6.	Matrix Metalloproteinases (MMPs)IBA 11/01/2009 - "Several studies indicate that MMPs and TIMPs may play a key role in the onset or progression of Dupuytren's disease and related disorders. " 02/01/2013 - "Matrix metalloproteinases (MMPs) are expressed in Dupuytren's contracture and play a role in matrix remodeling. " 02/01/2013 - "The mechanical environment in Dupuytren's contracture determines cell contractility and associated MMP-mediated matrix remodeling." 04/01/2012 - "The results presented here suggest that treatment of Dupuytren's contracture patients with CCH does not lead to any clinical adverse events associated with MMP inhibition." 04/01/2012 - "DNA copy number variations at chromosome 7p14.1 and chromosome 14q11.2 are associated with dupuytren's disease: potential role for MMP and Wnt signaling pathway."
7.	Metalloproteases (Metalloproteinases)IBA 06/01/2012 - "MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction." 09/01/2008 - "Metalloproteinase gene expression correlates with clinical outcome in Dupuytren's disease." 03/01/2007 - "A complete expression profile of matrix-degrading metalloproteinases in Dupuytren's disease." 10/01/2003 - "Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytren's disease." 09/01/2008 - "We have previously demonstrated that gene expression levels of matrix metalloproteinases (MMPs), related metalloproteinases "a disintegrin and metalloproteinase with thrombospontin motifs" (ADAMTSs), and tissue inhibitors of metalloproteinases (TIMPs) differed when comparing palmar fascia from 19 patients with Dupuytren's disease (DD) with 19 disease-free controls. "
8.	LipidsIBA 11/01/1992 - "The raised levels of serum lipids appeared to be associated with the pathogenesis of Dupuytren's disease, and this may help to explain the high incidence of Dupuytren's disease in alcoholic, diabetic and epileptic patients, since these conditions are also associated with raised serum lipid levels." 11/01/1992 - "We studied prospectively the relationship between serum lipids and Dupuytren's disease of the hand in 85 patients, 65 men and 20 women. " 11/01/1992 - "Lipids and Dupuytren's disease." 05/01/1983 - "Seventy-two surgically obtained Dupuytren's disease palmar-fat (DDPF) specimens and 18 location-matched specimens from patients not suffering from this disease (controls) were studied for their total lipid composition and de novo lipogenic activity. " 05/01/1983 - "Lipid composition and de novo lipid biosynthesis of human palmar fat in Dupuytren's disease."
9.	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 04/01/1998 - "In outpatients undergoing surgery for Dupuytren's contracture, a midhumeral block was used with the musculocutaneous and radial nerves blocked by lidocaine and the median and ulnar nerves blocked with bupivacaine. " 04/01/1998 - "Patients undergoing surgery for Dupuytren's contracture were randomized into two groups in a double-blind fashion: in the control group (n = 17), each of the four nerves was infiltrated with 10 mL of a mixture of 2% lidocaine and 0.5% bupivacaine, whereas in the selective group (n = 17), the R and MC nerves were blocked with 10 mL of 2% lidocaine each and the M and U nerves were blocked with 10 mL of 0.5% bupivacaine each. " 10/01/2019 - "Addition of liposome bupivacaine to forearm blocks for Dupuytren contracture release prolonged sensory block and improved pain scores without increasing side effects or impairing hand function. " 10/01/2019 - "We randomized 32 subjects scheduled for Dupuytren contracture release with collagenase Clostridium histolyticum injections to receive forearm blocks of the median and ulnar nerves with a mixture of 5 mL liposome bupivacaine 1.33% plus 2.5 mL bupivacaine hydrochloride 0.5% per nerve (n = 16) or 7.5 mL bupivacaine hydrochloride 0.5% alone per nerve (n = 16). " 10/01/2019 - "Effect of Bupivacaine Liposome Injectable Suspension on Sensory Blockade and Analgesia for Dupuytren Contracture Release."
10.	SuspensionsIBA 10/01/2019 - "Effect of Bupivacaine Liposome Injectable Suspension on Sensory Blockade and Analgesia for Dupuytren Contracture Release." 10/01/2019 - "To study the efficacy of bupivacaine liposome injectable suspension in prolonging sensory blocks of the median and ulnar nerves for subjects with Dupuytren contracture release by collagenase injection. "

Therapies and Procedures

1.	Fasciotomy 05/01/2021 - "Our study shows that repeat limited fasciectomy for selected patients presenting with recurrence of Dupuytren's disease can be an effective and safe treatment resulting in excellent patient-reported outcomes and levels of satisfaction. " 09/01/2012 - "Increasing options to treat Dupuytren disease include percutaneous needle fasciotomy (PNF), a minimally invasive technique that has proven to be effective for the treatment of primary disease. " 05/01/2006 - "The demand for percutaneous needle fasciotomy (PNF) as treatment for Dupuytren's disease is increasing because of its limited invasiveness, good outcome, limited number of complications, quick recovery, and overall patient satisfaction. " 05/01/2017 - "Our study results demonstrated that regional selective fasciectomy is a reliable and efficient method to treat Dupuytren's disease with low rates of complications and recurrence and the technique can be considered the gold standard. " 05/01/2016 - "These preliminary results indicate that IBS may be effective in enzymatic fasciotomy in Dupuytren's contracture.Cite"
2.	Injections 01/01/2023 - "An institutional review board-approved retrospective chart review was conducted for patients between 2010 and 2017 who received CCH injections for Dupuytren's contracture at a Veterans Affairs hospital. " 01/01/2019 - "CCH injections are a viable treatment for Dupuytren's contracture in the Australian public health setting." 10/01/2018 - "We hypothesize that the gaining popularity of CCH has resulted in a change in treatment patterns among providers, with increased utilization of CCH injections in the management of Dupuytren's contracture from 2012 to 2014. " 01/01/2018 - "Frequent single injections are adequate to treat palmar fibromatosis [3]. " 07/01/1999 - "We studied tissue from 20 patients with Dupuytren's disease, four samples of normal palmar fascia from patients undergoing carpal tunnel decompression and tissue from ten patients who had received perinodular injections of depomedrone into the palm five days before operation. "
3.	Therapeutics 10/01/2005 - "Careful assessment of hand function, establishing the indications for surgery at the right time, choice of the appropriate surgical approach and initiation of intensive hand therapy immediately after surgery are decisive for effective treatment of recurrent Dupuytren's contracture. " 01/01/2021 - "For patients with Dupuytren's disease, CCH therapy directly improved the health-related quality of life. " 03/01/1992 - "The purpose of this study was to prospectively compare the postoperative use of passive motion (PM) and standard hand therapy after surgical treatment of Dupuytren's disease for extent and rate of recovery of joint motion. " 12/01/2022 - "The inaccessibility of the drug has seen both an increase in surgery for the treatments of both PD and Dupuytren's disease and an interruption of therapies in patients who had not completed their therapeutic cycle. " 10/01/2022 - "Comparison of Hand Therapy with or without Splinting Postfasciectomy for Dupuytren's Contracture: Systematic Review and Meta-Analysis."
4.	Extracorporeal Shockwave Therapy 12/01/2019 - "Extracorporeal shockwave therapy was beneficial in relieving symptoms in Dupuytren's disease of the hand." 01/01/2022 - "It can be concluded that shock wave therapy can be effective in improving the symptoms and function of patients with Dupuytren's Contracture." 06/12/2020 - "While the efficacy of focused Extracorporeal Shock Wave Therapy (ESWT) in the treatment of Dupuytren's disease (DD) is supported by one positive trial, the effects of radial ESWT is unclear. " 12/01/2019 - "The objective of this study was to evaluate the effectiveness of shock-wave therapy on patients with Dupuytren's disease of the hand. " 01/01/2022 - "We aimed to evaluate the effect of shock wave therapy on the improvement of symptoms and function of patients with Dupuytren's contracture. "
5.	Radiotherapy 09/01/2017 - "We have systematically reviewed the evidence on the use of radiotherapy in Dupuytren's disease. " 09/01/2017 - "Radiotherapy has been advocated as an alternative treatment in early Dupuytren's disease. " 09/01/2017 - "Radiotherapy in Dupuytren's disease: a systematic review of the evidence." 10/01/2016 - "To remember: Radiotherapy - a successful treatment for early Dupuytren's disease." 05/01/2015 - "Radiotherapy with soft X-rays in Dupuytren's disease - successful, well-tolerated and satisfying."