Duodenal Obstruction

Hindrance of the passage of luminal contents in the DUODENUM. Duodenal obstruction can be partial or complete, and caused by intrinsic or extrinsic factors. Simple obstruction is associated with diminished or stopped flow of luminal contents. Strangulating obstruction is associated with impaired blood flow to the duodenum in addition to obstructed flow of luminal contents.

Also Known As:

Networked: 406 relevant articles (19 outcomes, 27 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Pancreatic Neoplasms (Pancreatic Cancer)
3.	Familial duodenal atresia
4.	Vomiting
5.	Carcinoma (Carcinomatosis)

Experts

1.	Higuchi, Kazuhide: 5 articles (03/2021 - 09/2014)
2.	Ogura, Takeshi: 5 articles (03/2021 - 09/2014)
3.	Sasahira, Naoki: 4 articles (05/2022 - 07/2012)
4.	Sasaki, Takashi: 4 articles (05/2022 - 07/2012)
5.	Masuda, Daisuke: 4 articles (05/2016 - 09/2014)
6.	Takeda, Tsuyoshi: 3 articles (05/2022 - 11/2020)
7.	Gerdes, Hans: 3 articles (04/2022 - 05/2010)
8.	Schattner, Mark A: 3 articles (04/2022 - 05/2010)
9.	Nakai, Yousuke: 3 articles (12/2021 - 07/2012)
10.	Isayama, Hiroyuki: 3 articles (01/2018 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Duodenal Obstruction:

1.	MetalsIBA 03/01/2003 - "Combined self-expandable metal stenting for simultaneous palliation of malignant biliary and duodenal obstruction may provide a safe and less invasive alternative to surgical palliation with an acceptable clinical outcome. " 05/01/2002 - "The aim of the study was to determine the efficacy of the endoscopic placement of metal self expanding duodenal stents for the palliation of malignant duodenal obstruction. " 04/01/2003 - "This study reports our experience with the use of self-expanding metal stents in the palliation of malignant gastric duodenal obstruction. " 03/01/2003 - "Previous studies have shown that self-expanding metal stents are an effective method for palliation of malignant biliary or duodenal obstruction. " 01/01/2023 - "To evaluate long-term outcomes of endoscopic double stenting using anti-reflux metal stents (ARMS) for combined malignant biliary and duodenal obstruction. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 07/01/1998 - "Idiopathic retroperitoneal fibrosis with duodenal obstruction successfully treated with corticosteroids." 12/03/1966 - "Idiopathic retroperitoneal fibrosis with protein-losing enteropathy and duodenal obstruction successfully treated with corticosteroids." 12/18/1965 - " of these patients had symptoms of severe duodenal obstruction and were relieved by bypass procedures and vagotomy; one required surgery because of co-existent obstructive ileal disease: and two patients have improved on corticoids and salicylazosulfapyridine without surgery.In"
3.	nitinolIBA 07/01/2006 - "Peroral placement of nitinol stents is an effective and easy method of mitigation for most patients with malignant gastro-duodenal obstructions. " 02/01/2006 - "Under fluoroscopic guidance, 82 patients (56 male and 26 female; mean age, 62.3 y) with malignant duodenal obstructions were treated with per oral placement of four types of self-expandable nitinol stents. " 02/01/2006 - "To assess the efficacy of fluoroscopic per oral placement of self-expandable nitinol stents in the palliative treatment of malignant duodenal obstructions. " 02/01/2006 - "Fluoroscopic per oral placement of self-expandable nitinol stents is an effective palliative treatment for malignant duodenal obstructions." 02/01/2006 - "Malignant duodenal obstructions: palliative treatment using self-expandable nitinol stents."
4.	SteroidsIBA 02/01/2004 - "Systemic steroid therapy had been shown to be effective in patients with Crohn's disease, and the most common indication for surgical intervention is duodenal obstruction. "
5.	Sulfasalazine (Azulfidine)FDA LinkGeneric 12/18/1965 - " of these patients had symptoms of severe duodenal obstruction and were relieved by bypass procedures and vagotomy; one required surgery because of co-existent obstructive ileal disease: and two patients have improved on corticoids and salicylazosulfapyridine without surgery.In"
6.	BariumIBA 12/01/2016 - "An upper gastrointestinal barium contrast study revealed distention of the duodenal bulb with an abrupt narrowing and subsequent dilation at the second portion of the duodenum raising the suggestion of multiple duodenal obstructions. " 01/01/2013 - "Gastroscopy and barium meal study showed diffuse polypoid, nodular lesions that affected the entire stomach, invaginating into the duodenum, leading to partial duodenal obstruction. " 10/01/2010 - "Diagnostic methods for identifying duodenal obstruction by the SMA include upper gastrointestinal barium contrast studies, computed tomography scans, or angiography of the aorta with either contrast or magnetic resonance angiography. " 03/01/1999 - "Late diagnosis was made in eight babies and led to prolonged hospitalization (mean 20 days), although duodenal obstruction was demonstrated by barium study in all 13 patients. " 01/01/1992 - "A review of barium meal studies in 32 cases of congenital intrinsic duodenal obstruction (CDO) from the Adelaide Children's Hospital was performed to assess and measure pre and post operative duodenal dilatation. "
7.	Alkaline PhosphataseIBA 12/01/2023 - "In the avasopasem group, grade 3-4 adverse events within 90 days of SBRT were acute kidney injury, increased blood alkaline phosphatase, haematoma, colitis, gastric obstruction, lung infection, abdominal abscess, post-surgical atrial fibrillation, and pneumonia leading to respiratory failure (one [4%] each).There were no treatment-related deaths but one late death in the avasopasem group due to sepsis in the setting of duodenal obstruction after off-study treatment was reported as potentially related to SBRT. "
8.	DiamondIBA 01/01/2009 - "Kimura's diamond-shaped-duodenoduodenostomy (DSD) is a known technique for the correction of congenital intrinsic duodenal obstruction. " 10/01/1977 - "A diamond-shaped side-to-side duodenoduodenal anastomosis has been performed in nine consecutive cases of congenital duodenal obstruction, with satisfactory results. " 10/01/1977 - "Diamond-shaped anastomosis for congenital duodenal obstruction." 09/01/1990 - "During the period between 1974 and 1988 44 patients were treated for congenital intrinsic duodenal obstruction using a diamond-shaped anastomosis (35 atresias, including two multiple atresias and nine stenoses). " 12/01/1997 - "Analysis of data obtained from the patients revealed that the duodenal obstruction was the most successfully treated by diamond-shaped duodenoduodenostomy, jejunal obstruction by resection of the dilated oral blind end, tapering jejunoplasty and ileal obstruction by resection of the dilated blind end and anastomosis or ileostomy in case with peritonitis. "
9.	AcidsIBA 06/01/1976 - "We believe that treatment should be directed toward relief of the duodenal obstruction and the reduction of basal acid secretion by truncal vagotomy in all such cases." 12/01/2016 - "99mTc-diisopropyliminodiacetic acid cholescintigraphy showed incidental absent transit of radiotracer into the distal duodenum and severe enterogastric reflux, thought to be secondary to duodenal obstruction from the hematoma. " 01/01/1990 - "Analysis of the causes of the unsatisfactory results of SPV in 39 patients has shown that the leading ones among them were the preservation of a high level of acid formation, antral stasis, chronic duodenal obstruction resulting from the extravasal compression of the celiac trunk and celiac ganglioneuritis. " 04/01/1986 - "Two Holstein heifers and a steer fitted with ruminal and duodenal cannulas were used to determine acid-base and electrolyte changes associated with metabolic alkalosis induced by duodenal obstruction. "
10.	PlasticsIBA 01/01/2017 - "Another patient with duodenal duplication cyst causing duodenal obstruction was managed by inserting a plastic stent through the cyst. " 03/01/2012 - "A separate Technology Review describes the models of biliary stents available and the stenting techniques, including advanced techniques such as insertion of multiple plastic stents, drainage of hilar strictures, retrieval of migrated stents and combined stenting in malignant biliary and duodenal obstructions.The" 07/01/1987 - "Lesions included heavy combative scarring of the head, grossly roughened and thickened skin on the lower left flank, cutaneous maculae, genital papillomatosis, partial duodenal obstruction by plastic debris, colo-rectal obstruction by ambergris, cystic degeneration of the right kidney, and a deeply ulcerative gastric nematodiasis. "

Therapies and Procedures

1.	Stents 02/01/2015 - "The newly designed stent is associated with a high degree of technical success and good clinical outcome and may be clinically effective in the management of malignant distal duodenal obstruction." 04/01/2022 - "Background and study aims  There are limited data on the success of endoscopic retrograde cholangiopancreatography (ERCP) in patients with malignant biliary and duodenal obstruction with a preexisting duodenal stent. " 12/01/2021 - "This study aimed to evaluate the feasibility of endoscopic ultrasound (EUS)-guided antegrade covered stent placement with long duodenal extension (EASL) for malignant distal biliary obstruction (MDBO) with duodenal obstruction (DO) or surgically altered anatomy (SAA) after failed endoscopic retrograde cholangiopancreatography (ERCP). " 01/01/2016 - "The present study suggests that X-ray fluoroscopy-guided intraluminal stent implantation is an effective procedure for the treatment of malignant biliary and duodenal obstruction." 01/01/2016 - "The aim of the present study was to evaluate the effectiveness of intraluminal dual stent placement in malignant biliary and duodenal obstruction. "
2.	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/01/2008 - "However, debate continues concerning the efficacy of gastrojejunostomy at preventing duodenal obstruction. " 06/01/2012 - "Endoscopic vs. laparoscopic gastrojejunostomy for duodenal obstruction: a randomized study in a porcine model." 02/01/2012 - "The purpose of this study was to develop a model for an entirely endoscopic gastrojejunostomy to treat duodenal obstruction, and to compare this with the laparoscopic technique. " 02/01/2012 - "Endoscopic vs. laparoscopic gastrojejunostomy for duodenal obstruction: a randomized study in a porcine model." 01/01/2023 - "Inflammatory and cicatricial lesions of gastrojejunostomy formed for congenital duodenal obstruction following annular pancreas required reconstructive surgery. "
3.	Vagotomy 07/01/1997 - "Duodenal obstruction was relieved by gastrojejunostomy in eight patients, gastrojejunostomy and vagotomy in eight patients, gastroduodenostomy and vagotomy in two patients, vagotomy with Finney pyloroplasty in one patient, duodenoplasty with vagotomy in one patient and Whipple procedure in four patients. " 06/01/1983 - "Indeed, choledochoduodenostomy, which has been carried out in combination with either gastrojejunostomy and vagotomy in the presence of duodenal obstruction or with pericystojejunostomy for the treatment of pancreatic pseudocyst, has been shown to be the treatment of choice." 06/01/1982 - "In the third patient, who had mural inflammation in the distal stomach and presumably in the duodenum as well, vagotomy and gastrojejunostomy relieved severe duodenal obstruction but not pain. " 12/18/1965 - " of these patients had symptoms of severe duodenal obstruction and were relieved by bypass procedures and vagotomy; one required surgery because of co-existent obstructive ileal disease: and two patients have improved on corticoids and salicylazosulfapyridine without surgery.In"
4.	Palliative Care (Palliative Therapy) 01/01/2021 - "Specifically, we describe 7 consecutive cases of malignant GDOO in which a duodenal HANAROSTENT® was placed for on-label use, defined as palliative treatment of malignant gastric and/or duodenal obstruction. " 12/01/2012 - "Uncovered SEMS placement is effective as a first-line palliative therapy for inoperable malignant duodenal obstruction. " 12/01/2012 - "Uncovered self-expandable metallic stent placement as a first-line palliative therapy in unresectable malignant duodenal obstruction." 04/01/2006 - "We evaluated palliative treatment for unresectable malignant stomach pyloric region and the duodenal obstruction using covered self-expandable metallic stent (SEMS). " 04/01/2003 - "Self-expandable metal stents placed endoscopically provide a safe, less invasive palliative treatment option with good clinical outcome in the management of malignant gastric outlet-duodenal obstruction."
5.	Drug Therapy (Chemotherapy) 01/01/2021 - "Palliative measures for unresectable tumours including relief from biliary and duodenal obstruction as well as chemotherapy should be considered in non-frail patients with reasonable life expectancy. " 01/01/2023 - "GJJ provides longer OS than EDSP for patients with GOO caused by URPC, especially for patients with good PS, biliary obstruction, and duodenal obstruction near the papilla, and those receiving chemotherapy." 01/01/2023 - "Subgroup analyses showed that OS in patients with good performance status (PS; p = 0.041), biliary obstruction (p = 0.007), and duodenal obstruction near the papilla (p = 0.027), and those receiving chemotherapy (p = 0.010), was significantly longer in the matched GJJ group than in matched EDSP group. " 07/29/2021 - "As the prognosis of periampullary cancer has improved due to recent advances in chemotherapy, treatment strategies for biliary and duodenal obstruction are becoming more important. " 06/01/2013 - "Endoscopic self-expandable metallic stent placement in malignant pyloric or duodenal obstruction: does chemotherapy affect stent patency?"