Patent Ductus Arteriosus

A congenital heart defect characterized by the persistent opening of fetal DUCTUS ARTERIOSUS that connects the PULMONARY ARTERY to the descending aorta (AORTA, DESCENDING) allowing unoxygenated blood to bypass the lung and flow to the PLACENTA. Normally, the ductus is closed shortly after birth.

Also Known As:

Ductus Arteriosus, Patent; Patency of the Ductus Arteriosus; Patent Ductus Arteriosus Familial

Networked: 3238 relevant articles (149 outcomes, 316 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	Sepsis (Septicemia)
3.	Birth Weight (Birth Weights)
4.	Pneumothorax
5.	Bronchopulmonary Dysplasia

Experts

1.	McNamara, Patrick J: 29 articles (06/2022 - 01/2010)
2.	Clyman, Ronald I: 28 articles (01/2022 - 09/2003)
3.	Jain, Amish: 20 articles (01/2022 - 04/2012)
4.	Erdeve, Omer: 20 articles (10/2017 - 09/2008)
5.	Ohlsson, Arne: 16 articles (11/2020 - 04/2010)
6.	Dilmen, Ugur: 16 articles (04/2017 - 04/2009)
7.	Sehgal, Arvind: 13 articles (12/2021 - 01/2010)
8.	Weisz, Dany E: 13 articles (10/2021 - 01/2014)
9.	Shah, Prakesh S: 13 articles (11/2019 - 01/2004)
10.	Uras, Nurdan: 13 articles (10/2017 - 04/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Patent Ductus Arteriosus:

1.	Ibuprofen (Motrin)FDA LinkGeneric 01/01/2013 - "There are few published reports concerning the efficacy of oral ibuprofen for the treatment of patent ductus arteriosus (PDA) in extremely low birth weight (ELBW) infants. " 05/01/2000 - "This study was aimed at evaluating the efficacy of ibuprofen in the prophylaxis of patent ductus arteriosus (PDA) in very preterm neonates and at detecting eventual side-effects. " 08/01/2023 - "What is Known: • Ibuprofen is the current first-line treatment for patent ductus arteriosus during the early neonatal period in very preterm infants. " 05/01/2016 - "To compare the efficacy of intravenous ibuprofen at high (20-10-10mg/kg/dose) and low doses (10-5-5mg/kg/dose) the closure of patent ductus arteriosus in preterm newborns. " 04/01/2012 - "Improved closure of patent ductus arteriosus with high doses of ibuprofen."
2.	Indomethacin (Indometacin)FDA LinkGeneric 06/01/1988 - "Indomethacin has proven effective in closing the patent ductus arteriosus (PDA) in most low birth weight (LBW) neonates with this disorder. " 04/01/2013 - "After the introduction of a new protocol based on the early treatment with indomethacin for patent ductus arteriosus, the objective of this study was to assess the safety and efficacy of this new practice in comparison with the safety and efficacy of the conventional treatment in a high-risk population. " 04/01/2004 - "Is oral indomethacin effective in treatment of preterm infants with patent ductus arteriosus?" 11/01/1998 - "Postnatally, therapeutic indomethacin administration is usually effective in mediating patent ductus arteriosus (PDA) constriction in premature infants. " 09/01/1993 - "Indomethacin has been demonstrated to be effective for closure of hemodynamically symptomatic patent ductus arteriosus (PDA) in premature infants. "
3.	Acetaminophen (Paracetamol)FDA LinkGeneric 03/01/2021 - "What is Known: • The successful closure of patent ductus arteriosus with oral paracetamol has been recently reported in several preterm infants, but only one randomized controlled study investigated the efficacy of intravenous paracetamol. " 01/01/2016 - "To compare the efficacy of oral and intravenous paracetamol for closure of hemodynamically significant patent ductus arteriosus (HSPDA) in very low birth weight (VLBW) preterm infants. " 08/01/2018 - "Paracetamol has been suggested as an effective treatment for patent ductus arteriosus (PDA). " 08/01/2015 - "In our experience, lower-dose paracetamol is effective in closing the patent ductus arteriosus in 83.3% of the cases." 08/01/2015 - "Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants."
4.	beta-apocarotenoid-14',13'-dioxygenase (ADO)IBA 08/01/2013 - "To evaluate safety and efficacy of closure of patent ductus arteriosus (PDA) with Amplatzer duct occluder II Additional Sizes (ADO II AS) and to report early and midterm results of the device in children and very young symptomatic infants. " 06/01/2012 - "The objective of this study was to evaluate the technical feasibility, safety, and efficacy of the new device Amplatzer duct occluder II additional sizes (ADO II AS) for closure of patent ductus arteriosus (PDA). " 05/01/2017 - "The study purpose is to evaluate the safety and efficacy of the ADO II device for closure of patent ductus arteriosus (PDA) in children. " 01/01/2001 - "The aim of the study was to assess the safety and efficacy of the Amplatzer ductal occluder (ADO) in transcatheter occlusion of patent ductus arteriosus (PDA). " 07/15/2004 - "This study compared the efficacy and costs of the most used approaches for percutaneous closure of large patent ductus arteriosus, that is, multiple coils and the Amplatzer duct occluder (ADO) device. "
5.	Oxygen (Dioxygen)IBA 08/15/2021 - "To study the change in regional oxygen saturation (rSO2) of intestinal tissue in preterm infants with hemodynamically significant patent ductus arteriosus (hsPDA) by near-infrared spectroscopy, and the clinical significance of the change in intestinal oxygen level in preterm infants with hsPDA. " 08/01/2014 - "This study aimed to examine the differences between arterial and inferior caval vein oxygen saturation, fractional oxygen extraction, and the shunt index, which were calculated in the diagnosis of patent ductus arteriosus. " 01/01/2022 - "Independent risk factors associated with ROP treatment included lower gestational age, small for gestational age, multiple birth, severe intraventricular haemorrhage, patent ductus arteriosus and supplemental oxygen duration. " 05/01/2021 - "In a model comprising region of primary care, GA [odds ratios (OR): 0.65; 95% CI: 0.55-0.77], growth velocity (OR: 1.10; 95% CI: 1.00-2.00), medically treated patent ductus arteriosus (OR: 1.80; 95% CI: 1.19-2.72), weeks of supplemental oxygen (OR: 1.07; 95% CI: 1.03 to 1.11) and region of primary care (OR: 4.95; 95% CI: 3.05-8.04 for the pair of regions with the highest estimated OR) were significantly associated with severe ROP. " 01/01/2019 - "The patent ductus arteriosus (PDA) can also shunt blood from the pulmonary arteries to the aorta, bypassing the lungs and causing oxygen-poor blood to mix with the oxygen-rich blood circulating to the body. "
6.	SteroidsIBA 10/17/2017 - "The rate of patent ductus arteriosus increased in the group receiving inhaled steroids (RR 1.64, 95% CI 1.23 to 2.17; RD 0.21, 95% CI 0.10 to 0.33; 1 trial, N = 278; NNTH 5, 95% CI 3 to 10). " 05/16/2012 - "The rate of patent ductus arteriosus was increased in the group receiving inhaled steroids [RR 1.64 (95% CI 1.23 to 2.17); RD 0.21 (95% CI 0.10 to 0.33); one trial, n = 278; NNTH 5 (95% CI 3 to 10)]. " 01/01/2003 - "There was a statistically significant increase in the rate of patent ductus arteriosus (RR 1.64, 95% CI 1.23, 2.17; RD 0.21, 95% CI 0.10, 0.33; 1 trial and n = 278) in the group receiving inhaled steroids. " 01/01/2023 - "SG2017 had 9.9% higher usage of antenatal steroids (p < 0.001), 8% better survival for infants ≤26 weeks (p = 0.174), and used 12.7% lesser nonsteroidal anti-inflammatory drugs for patent ductus arteriosus closure (p < 0.001) than those of SG2007 cohort. " 01/01/2009 - "Non-steroid anti-inflammatory drugs in the treatment of patent ductus arteriosus in European newborns."
7.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/01/2023 - "We aimed to develop and validate an interpretable machine-learning model for predicting the efficacy of NSAIDs for closing hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants. " 01/01/2021 - "To establish the feasibility of a future large randomized trial to compare early treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) while awaiting spontaneous patent ductus arteriosus (PDA) closure. " 11/01/2014 - "Comparison of Oral Versus Intravenous Nsaids for the Treatment of Patent Ductus Arteriosus in Preterm and/or Low Birth Weigh Infants: A Systematic Review and Meta-Analysis." 01/01/2014 - "Non-steroidal anti-inflammatory drugs (NSAIDs) in the management of patent ductus arteriosus (PDA) in preterm infants and variations in attitude in clinical practice: a flight around the world." 10/01/2011 - "Renal safety of Non Steroidal Anti Inflammatory Drugs (NSAIDs) in the pharmacologic treatment of patent ductus arteriosus."
8.	Alprostadil (Muse)FDA LinkGeneric 02/01/1993 - "The study demonstrates the efficacy of PGE1 in maintaining the patency of the ductus arteriosus; we therefore propose that this drug should be used, though with caution, routinely in peripheral hospitals before such patients are transferred to specialised centres for further diagnostic and therapeutic intervention." 11/01/2013 - "In order to maintain patency of the ductus arteriosus (DA), the first line treatment is Prostaglandin E1 and the second step is the surgical creation of aortic-pulmonary shunt. " 03/01/1994 - "Prostaglandin E1 (PGE1) infusion, initiated to achieve patency of the ductus arteriosus, produced improved oxygenation and cardiovascular status in both infants. " 04/01/2021 - "Patency of the ductus arteriosus from the left subclavian artery was maintained with prostaglandin E1. " 05/14/2020 - "Patients with coarctation were receiving prostaglandin E1 and had a patent ductus arteriosus. "
9.	Furosemide (Lasix)FDA LinkGeneric 12/07/2011 - "Furosemide-induced transient improvement in pulmonary function did not outweigh an increased risk for patent ductus arteriosus and for hemodynamic instability. " 01/23/2008 - "Furosemide-induced transient improvement in pulmonary function did not outweigh an increased risk for patent ductus arteriosus and for hemodynamic instability. " 01/01/2001 - "Furosemide-induced transient improvement in pulmonary function did not outweigh an increased risk for patent ductus arteriosus and for hemodynamic instability. " 01/01/2000 - "Furosemide-induced transient improvement in pulmonary function did not outweigh an increased risk for patent ductus arteriosus and for hemodynamic instability. " 12/01/2022 - "The role of furosemide and fluid management for a hemodynamically significant patent ductus arteriosus in premature infants."
10.	Caffeine (No Doz)FDA LinkGeneric 01/22/2018 - "In recent studies, effects of caffeine on the cardiovascular system have been emphasized in preterm infants with patent ductus arteriosus (PDA). " 01/01/2019 - "Two (4%) infants from the caffeine group and 1 (2%) infant from the control group had a positive patent ductus arteriosus and needed treatment. " 01/01/2018 - "Following concerns for caffeine safety in preterm infants, a large randomized controlled trial demonstrated a reduction in BPD and treatment for patent ductus arteriosus. " 08/01/2007 - "A recent, randomized, placebo-controlled, multicenter trial found that infants who were randomly assigned to caffeine treatment had less need for pharmacologic and/or surgical closure of a patent ductus arteriosus (PDA). " 01/01/2022 - "There are multiple clinical benefits of caffeine treatment, including improved extubation success, a reduced duration of mechanical ventilation, improved lung function, and a reduction of patent ductus arteriosus requiring treatment. "

Therapies and Procedures

1.	Ligation 11/01/2003 - "Video-assisted thoracic surgery is a safe and effective technique for patent ductus arteriosus ligation in premature infants, including those with very low and extremely low birth weight." 09/01/2023 - "Transcatheter device closure of patent ductus arteriosus (PDA) in preterm infants has been proven to be a feasible and safe technique with promising results when compared to surgical ligation. " 06/01/1996 - "Open surgical ligation has proven to be a safe and effective method to bring about closure of the patent ductus arteriosus (PDA). " 06/01/1984 - "Results indicate that surgical ligation is a safe and effective procedure for treating patent ductus arteriosus with large left-to-right shunting in small premature infants." 01/01/2022 - "Is early patent ductus arteriosus ligation helpful in premature neonates? "
2.	Therapeutics 06/01/2016 - "Transcatheter therapy is the first-line treatment for closure of patent ductus arteriosus (PDA). " 01/01/1986 - "Patent ductus arteriosus was the first inborn cardiac defect ever eliminated by percutaneous transvascular therapy. " 08/01/2018 - "AimThe aim of this study was to determine the spontaneous closure rate of patent ductus arteriosus at a 2-year follow-up, following failed medical therapy and beyond initial hospital discharge, and to evaluate in-hospital spontaneous or pharmacological closure rates.Materials" 11/01/2017 - "The objective of the present study was to characterise the association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants. " 08/01/2002 - "The aim of the study was to observe the inflammatory changes during the therapy for symptomatic patent ductus arteriosus (sPDA). "
3.	Catheters 03/01/2018 - "Trans-catheter device closure of patent ductus arteriosus (PDA) via femoral route is the commonly used, safe and effective procedure. " 11/15/1988 - "Catheter occlusion of the patent ductus arteriosus using the Rashkind umbrella appears to be a safe and effective method of non-surgical management." 08/01/2010 - "Document safety and efficacy of transvenous catheter occlusion of patent ductus arteriosus (PDA) over a wide range of ductal and patient sizes. " 11/01/2019 - "Catheter-based closure of the patent ductus arteriosus in preterm infants: considerations in the design of a randomized trial." 07/01/2016 - "Data of 250 patients who underwent patent ductus arteriosus (PDA) closure either surgical or trans-catheter closure using SHSMA Occluder having weight >5 kg from April 2012 to October 2015 were included in this study. "
4.	Artificial Respiration (Mechanical Ventilation) 10/30/2023 - "The study group showed a reduction in the need for mechanical ventilation (not statistically significant) and a statistically significant reduction in hemodynamically significant patent ductus arteriosus with respect to the control group (19/68 (28%) vs. 35/65 (54%), respectively, p = 0.03). " 12/15/2022 - "The multivariate logistic regression analysis showed that a long duration of invasive mechanical ventilation (OR=1.320, P<0.05), hemodynamically significant patent ductus arteriosus (OR=2.032, P<0.05), and a prolonged time to reach oral calorie goal of 110 kcal/(kg·d) (OR=1.041, P<0.05) were risk factors for BPD, while an older gestational age was a protective factor against BPD (OR=0.535, P<0.05). " 06/01/2020 - "On adjusted analysis compared with matched controls, cases had higher odds of requiring invasive mechanical ventilation (OR 3.6, 95% CI: 1.1-11.6, p=0.035) and of a patent ductus arteriosus (PDA) (OR 3.0, 95% CI: 1.0-9.0, p=0.044). " 01/01/2020 - "Transcatheter closure of patent ductus arteriosus is safe, effective and is associated with shorter mechanical ventilation than after surgery. " 01/01/2018 - "A persistent left-to-right shunt through a patent ductus arteriosus (PDA) increases the rate of hydrostatic fluid filtration into the lung's interstitium, impairs pulmonary mechanics, and prolongs the need for mechanical ventilation. "
5.	Thoracotomy 01/01/2020 - "To date, a posterolateral thoracotomy approach is considered the gold standard for surgical closure of patent ductus arteriosus (PDA), also in preterm neonates. " 06/23/2023 - "Thoracotomy with posterolateral incision (PLI) is commonly used for surgical repair of patent ductus arteriosus (PDA) in extremely low birth weight (ELBW) infants. " 05/25/2022 - "Data of 27 preterm infants operated by the same surgeon who underwent Patent ductus arteriosus (PDA) closure with left anterior mini-thoracotomy technique between November 2020 and January 2022 at a single institution were reviewed. " 01/01/2022 - "Data from preterm infants with patent ductus arteriosus clipping (surgery) via a left postero-lateral thoracotomy were compared with infants in whom the patent ductus arteriosus closed: spontaneously, with medications or use of an occlusive device (controls). " 11/18/2021 - "Interestingly, our patient had undergone an open thoracotomy for surgical closure of a patent ductus arteriosus (PDA) under general anaesthesia 12 years ago in the absence of any appreciable shunt across the ligated ductus at present. "