Duane Retraction Syndrome (Duane Syndrome)

Subscribe to Selected New Research on Duane Retraction Syndrome

30 relevant articles (2 outcomes, 1 trials/studies) found for this Disease

Description: A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the oculomotor nerve. There are three subtypes: type 1 (associated with loss of abduction), type 2 (associated with loss of adduction), and type 3 (loss of abduction and adduction). Two loci for Duane retraction syndrome have been located, one at chromosome 8q13 (DURS1) and another at chromosome 2q31(DURS2). It is usually caused by congenital hypoplasia of the abducens nerve or nucleus, but may rarely represent an acquired syndrome. (Adams et al., Principles of Neurology, 6th ed, p271; Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p691)

Also Known As:

Duane Syndrome; Syndrome, Duane; Duanes Syndrome; Syndrome, Duane's; Duane Retraction Syndrome, Type 1; Duane Retraction Syndrome, Type 2; Duane Retraction Syndrome, Type 3; Duane's Syndrome; Okihiro Syndrome; Type 1 Duane Retraction Syndrome; Type 2 Duane Retraction Syndrome; Type 3 Duane Retraction Syndrome; Ocular Retraction Syndromes; Retraction Syndromes, Ocular; Ocular Retraction Syndrome

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3422

Cranial Nerve Diseases: 147

Ocular Motility Disorders: 202

Duane Retraction Syndrome: 30

Eye Diseases: 1245

Ocular Motility Disorders: 202

Duane Retraction Syndrome: 30

Hereditary Eye Diseases: 7

Duane Retraction Syndrome: 30

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 422

Inborn Genetic Diseases: 549

Hereditary Eye Diseases: 7

Duane Retraction Syndrome: 30

Related Diseases

1.	Paralysis (Palsy)
2.	Esotropia (Esophoria)
3.	Syndrome
4.	Abducens Nerve Diseases (Sixth Nerve Palsy)
5.	Strabismus (Squint)

Experts

1.	Vargas-Ortega, Jessica: 1 article (04/2007)
2.	Garnica-Hayashi, Rosa E: 1 article (04/2007)
3.	Zenteno, Juan Carlos: 1 article (04/2007)
4.	Eirís, Jesús: 1 article (11/2006)
5.	Gómez-Lado, Carmen: 1 article (11/2006)
6.	Blanco, Oscar: 1 article (11/2006)
7.	Martínez-Yriarte, José Manuel: 1 article (11/2006)
8.	Castro-Gago, Manuel: 1 article (11/2006)
9.	Frecer, Vladimir: 1 article (03/2006)
10.	Tonini, Giorgio: 1 article (03/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Duane Retraction Syndrome:

1.	Transcription Factors (Transcription Factor)IBA 12/01/2007 - "PURPOSE: The authors used magnetic resonance imaging (MRI) to study extraocular muscles (EOMs) and nerves in Duane-radial ray (Okihiro) syndrome (DRRS) caused by mutations in the transcription factor SALL4" 07/01/2003 - "We have recently shown that Okihiro syndrome results from mutation in the putative zinc finger transcription factor gene SALL4 on chromosome 20q13.13-13.2" Order ALL the reference details at left...
2.	Carbon MonoxideIBA 10/01/2004 - "In Duane syndrome, lateral rectus inactivation markedly reduced co-contraction and globe retraction" 03/01/2002 - "This case also suggests the possibility that some part of the upshoot in adduction in Duane's syndrome is due to the co-contraction of the superior and medial rectus muscles due to this innervation anomaly." 11/01/1991 - "Occult Duane syndrome: co-contraction revealed following strabismus surgery." 01/01/1988 - "In a bilateral horizontal Duane's syndrome, the physiological co-contraction of abnormally short horizontal recti in vertical gaze was responsible for vertical retraction syndrome and even for a positive vertical forced duction test" 03/01/1979 - "We used an adjustable transposition procedure in two cases of horizontal abduction deficiency (one of lateral rectus palsy and one of Duane syndrome with marked co-contraction)" Order ALL the reference details at left...
3.	DNA (Deoxyribonucleic Acid)IBA 03/01/2006 - "A SALL4 zinc finger missense mutation predicted to result in increased DNA binding affinity is associated with cranial midline defects and mild features of Okihiro syndrome." 03/01/1999 - "METHODS: Microsatellite analysis was used to examine genomic DNA isolated from members of a large family with autosomal dominant Duane retraction syndrome for linkage to candidate loci for Duane retraction syndrome" 06/01/2002 - "In Duane's syndrome, three chromosomal loci have been identified to date: 2q31, 8q13, and 22q11; loci have also been identified in Moebius syndrome (various inheritance patterns): 13q12.2-q13, 3q21-q22, and 10q21.3-q22, as well as in congenital fibrosis of the extraocular muscles (CFEOM; 3 loci, 1 gene).(1) Already identified are the genes for a number of rarer muscular dystrophy syndromes with ocular involvement, various forms of congenital myasthenia, and mitochondrial diseases (with the primary defect located either in the mtDNA, resulting in a mitochondrial inheritance pattern, or in the nuclear DNA with Mendelian inheritance)" Order ALL the reference details at left...
4.	Retinaldehyde (Retinal)IBA 04/01/2007 - "Left-sided Duane's syndrome and retinal coloboma associated with contralateral microphthalmia." 12/01/2002 - "Cone-rod retinal dystrophy and Duane retraction syndrome in a patient with achondroplasia." Order ALL the reference details at left...
5.	Botulinum Toxins (Botulinum Toxin)IBA 03/01/1993 - "We report on four patients from the botulinum toxin clinic at Moorfields Eye Hospital with Duane syndrome, who exhibited paradoxical medial rectus activity" 09/01/1991 - "Injections of botulinum toxin into the oculomotor muscles was used in incorrectible diplopia, ocular torticollis, Duane's syndrome and congenital nystagmus" Order ALL the reference details at left...
6.	Complementary DNA (cDNA)IBA 09/01/2002 - "Using both genomic and cDNA mouse and human clones encoding a neural-specific bHLH protein, human BHLHB5 was cloned and mapped to a region on chromosome 8q13 that segregates with Duane syndrome" Order ALL the reference details at left...
7.	Thalidomide (Thalomid)FDA Link 07/01/2003 - "Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy." Order ALL the reference details at left...
8.	Growth Hormone (Somatotropin)IBA 04/01/2003 - "A 4-year-old Italian child with the association of a solitary median maxillary central incisor, growth hormone deficiency, Duane retraction syndrome and a duplicated thumb phalanx is described." 04/01/2003 - "Solitary median maxillary central incisor, Duane retraction syndrome, growth hormone deficiency and duplicated thumb phalanx: a case report." Order ALL the reference details at left...
9.	Messenger RNA (mRNA)IBA 06/13/2005 - "The presence of CPA6 mRNA in the rectus muscle layer of the eye at embryonic day 14.5 is consistent with the observation that the CPA6 gene is disrupted in a patient with Duane syndrome, a congenital eye defect" Order ALL the reference details at left...
10.	Prostaglandins A (PGA)IBA 05/20/1994 - "We report a case of polyglandular autoimmune syndrome (PGA) complicated by Duane's syndrome" 05/20/1994 - "Case report of sister with Duane's syndrome and PGA, or myasthenia gravis]" Order ALL the reference details at left...

Therapies and Procedures

1.	Sutures (Suture) 05/01/2005 - "PARTICIPANTS: Twelve consecutive patients with ADD and Duane's syndrome type 2. INTERVENTIONS: Six patients treated by the full tendon rectus muscle transposition procedure alone were compared with 6 patients treated by the full tendon rectus muscle transposition combined with posterior medial fixation sutures" 05/01/2005 - "PURPOSE: To compare the surgical and functional results of full tendon rectus muscle transposition to the medial rectus muscle augmented with posterior medial fixation sutures in patients with adduction deficiency (ADD) and Duane's syndrome type 2. DESIGN: Retrospective nonconcurrent interventional comparative case series" 04/01/2001 - "CONCLUSIONS: Subjects with Duane syndrome and esotropia in primary position who had undergone augmented transposition of the vertical rectus muscles obtained improved head position and better alignment in primary position and had a reduction in the incidence of reoperation for undercorrection when compared with similar patients who had undergone vertical rectus muscle transposition without posterior lateral augmentation sutures." 07/01/2002 - "PURPOSE: Full tendon rectus muscle transposition surgery augmented with posterior fixation sutures has been shown to be effective in the treatment of abducens palsy and Duane's syndrome" 03/01/1997 - "CONCLUSIONS: The addition of lateral fixation sutures to full vertical rectus muscle transpositions improves the tonic abducting force of the procedure for patients with lateral rectus palsy and type I Duane syndrome without compromising adduction." Order ALL the reference details at left...
2.	Denervation 01/01/2001 - "Duane's syndrome with compressive denervation of the lateral rectus muscle." 11/01/2006 - "The sparing of the LR in Duane syndrome from denervation atrophy despite absence of normal abducens innervation suggests existence of alternative LR innervation" Order ALL the reference details at left...
3.	Decompression 01/01/2001 - "Grand rounds #64: a case of deterioration of ocular motility in a patient with unilateral type I Duane syndrome after contralateral orbital decompression." Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Duane Retraction Syndrome

*WARNING* This specific disease subtype has a relatively small number of significant evidence outcomes. You may proceed to order anyway, or go back to the search field and enter a more general type of the target illness. Once your report has been ordered, however, we can't refund the purchase.

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 2 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>