Dracunculiasis

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49 relevant articles (6 outcomes, 3 trials/studies) found for this Disease

Description: Infection with nematodes of the genus Dracunculus. One or more worms may be seen at a time, with the legs and feet being the most commonly infected areas. Symptoms include pruritus, nausea, vomiting, diarrhea, or asthmatic attacks.

Also Known As:

Dracunculiases; Dracunculoses; Infection, Guinea Worm; Dracunculosis; Guinea Worm Infection

Relationship Network

Disease Context: Research Results

Parasitic Diseases: 530

Helminthiasis: 264

Nematode Infections: 374

Secernentea Infections

Spirurida Infections: 2

Dracunculiasis: 49

Related Diseases

1.	Onchocerciasis
2.	Filariasis
3.	Chagas Disease (American Trypanosomiasis)
4.	Trypanosomiasis
5.	Malaria

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dracunculiasis:

1.	Metronidazole (Metric)FDA LinkGeneric 07/01/1979 - "In a clinical trial of metronidazole for dracunculiasis (75 cases), the drug was effective in giving symptomatic relief but had no preventive or vermicidal action" 07/01/1979 - "Efficacy of metronidazole in dracunculiasis" 03/01/1977 - "Two-hundred and twenty-nine cases dracunculiasis were selected for a double-blind trial of metronidazole against placebo" 03/01/1977 - "Metronidazole ("Flagyl") in dracunculiasis: a double blind study." 06/16/1974 - "Metronidazole in the treatment of Dracunculosis." Order ALL the reference details at left...
2.	1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA 09/13/2002 - "The findings indicate that DEP has succeeded in reducing incidence of dracunculiasis substantially; the disease can be eradicated if the remaining 13 countries in which it is endemic detect and contain transmission from the final cases." 07/01/2005 - "This study, undertaken as a component of the global Dracunculiasis Eradication Program (DEP), was designed to provide molecular tools to distinguish Dracunculus medinensis, the nematode causing human dracunculiasis, from other tissue-dwelling nematodes, including other Dracunculus species that infect humans and other animals" 07/01/2005 - "medinensis that will permit the DEP to determine, rapidly and accurately, whether a worm recovered from an area considered dracunculiasis-free is a specimen of D" 09/24/2004 - "This report describes the status of the global dracunculiasis eradication program (DEP) as of the end of 2003" 09/19/2003 - "This report describes the status of the global Dracunculiasis Eradication Program (DEP)* as of June 2003" Order ALL the reference details at left...
3.	Thiabendazole (Mintezol)FDA Link 11/01/1969 - "Efficacy of thiabendazole in the treatment of dracunculiasis." 10/01/1990 - "Thiabendazole has been used at 50 mg.kg-1 in one oral dose to test its efficiency as dracunculiasis prophylaxis" 10/01/1990 - "Failure of thiabendazole in the prevention of dracunculosis]" 02/01/1978 - "400 cases of dracunculosis were treated with Thiabendazole and the results reported" 11/01/1975 - "Thiabendazole in the treatment of dracunculosis." Order ALL the reference details at left...
4.	TemefosIBA 12/01/1991 - "Evaluation of the efficacy of temephos in the campaign against dracunculosis]" 09/02/1995 - "Dracunculiasis, Guinea-worm disease, can be prevented by boiling drinking water or filtering it through a cloth to remove the larvae's copepod hosts, by educating villagers not to contaminate their sources, by providing clean drinking water from underground sources such as borehole wells which cannot be contaminated, or by using a larvicide, temephos, to kill the copepods while leaving the water safe for human consumption" Order ALL the reference details at left...
5.	Minocycline (Cyclops)FDA LinkGeneric 05/01/1987 - "Rotenoids from indigofera tinctoria and their bio-efficacy against cyclops, the carrier of dracunculiasis." Order ALL the reference details at left...
6.	Ivermectin (Mectizan)FDA Link 10/01/1997 - "ORSTOM's close collaboration with TDR since the TDR Special Program was launched in 1975 has led to 1) improved knowledge about various aspects of trypanosomiasis that allowed identification of ways to control the epidemic; 2) reappraisal of the taxonomy of the parasitic protozoa responsible for Chagas disease and leishmaniasis; 3) improvements in the strategy to fight malaria; 4) assessment of the efficacy of ivermectin as a form of mass treatment for onchocerciasis; 5) improved knowledge about dracunculiasis that contributed to an eradication campaign; 6) expansion of the scope of biological control of bancroftian filariasis and other parasites; and 7) improved knowledge about ways to control two schistosome species" Order ALL the reference details at left...
7.	Heterophile AntigensIBA 09/01/1977 - "Comparison of the results obtained with homologous and heterologous antigens in the immunological study of onchocercosis and dracunculosis]" Order ALL the reference details at left...
8.	AntigensIBA 12/01/1990 - "The Falcon assay screening test-enzyme-linked immunosorbent assay (FAST-ELISA) and the enzyme-linked immunoelectrotransfer blot (EITB) technique were used to test human sera with Dracunculus medinensis adult worm antigen in order to assess their potential value in the immunodiagnosis of dracunculiasis" 07/30/1998 - "Sera from individuals living in a dracunculiasis endemic area of northern Ghana were examined for circulating Dracunculus medinensis antigens by applying protocols previously developed for detection of circulating antigens in other helminth infections" 03/01/2008 - "In parallel, diminished IFN-gamma and IL-12 responses to antigens from Ascaris lumbricoides, Entamoeba histolytica and mycobacteria were observed in patent and post-patent dracunculiasis cases" 03/01/1996 - "The enzymes linked immunosorbent assay (ELISA) was used to test human sera from patients with prepatent and patent Dracunculus medinensis infection with adult worm antigen to asses its potential value in the Immunodiagnosis of early asymptomatic guinea worm infection" 07/01/1993 - "Sera from individuals in Nigeria and the United States residing in areas nonendemic for onchocerciasis were uniformly nonreactive with these antigens in IgG and IgG4 assays, as were sera from patients with bancroftian filariasis, brugian filariasis, loiasis, ascariasis, schistomiasis, and dracunculiasis" Order ALL the reference details at left...
9.	NiridazoleIBA 10/06/1969 - "Niridazole in guinea worm infection." 07/01/1969 - "Niridazole (Ambilhar) in the treatment of dracunculiasis." 11/01/1968 - "Niridazole in dracunculiasis." 07/01/1968 - "Ambilhar--a new drug for the treatment of schistosomiasis,dracunculosis and amoebiasis]" Order ALL the reference details at left...
10.	Mebendazole (Vermin)FDA Link 03/01/1991 - "Mebendazole treatment of dracunculiasis." 09/01/1976 - "Preliminary report on the therapeutic effect of mebendazole in guinea worm infection." 03/01/1983 - "A note on the relative merits of metronidazole and mebendazole against dracunculiasis in the field." Order ALL the reference details at left...

Therapies and Procedures

1.	Traditional Medicine (Folk Remedies) 02/01/1991 - "Data were collected on history of dracunculiasis, occupational and domestic sources of drinking water, clinical manifestations, disability, use of folk medicine, and incorporation of previous dracunculiasis control programmes" Order ALL the reference details at left...
2.	Canes (Cane) 01/01/1992 - "The impact of dracunculiasis in a sugar-cane plantation." Order ALL the reference details at left...

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