Double Outlet Right Ventricle

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97 relevant articles (2 outcomes, 4 trials/studies) found for this Disease

Description: Incomplete transposition of the great vessels in which both the AORTA and the PULMONARY ARTERY arise from the RIGHT VENTRICLE. The only outlet of the LEFT VENTRICLE is a large ventricular septal defect (VENTRICULAR SEPTAL DEFECTS or VSD). The various subtypes are classified by the location of the septal defect, such as subaortic, subpulmonary, or noncommitted.

Also Known As:

Double Outlet Right Ventricle, Noncommitted VSD; Double Outlet Right Ventricle, Subaortic VSD; Double Outlet Right Ventricle, Subpulmonary VSD; Anomaly, Taussig-Bing; Taussig Bing Anomaly; Taussig-Bing Anomaly

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 18449

Heart Diseases: 12331

Congenital Heart Defects: 685

Transposition of Great Vessels: 19

Double Outlet Right Ventricle: 97

Cardiovascular Abnormalities: 167

Congenital Heart Defects: 685

Transposition of Great Vessels: 19

Double Outlet Right Ventricle: 97

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 420

Congenital Abnormalities: 9308

Cardiovascular Abnormalities: 167

Congenital Heart Defects: 685

Transposition of Great Vessels: 19

Double Outlet Right Ventricle: 97

Related Diseases

1.	Pulmonary Valve Stenosis (Pulmonary Stenosis)
2.	Ventricular Heart Septal Defects (Ventricular Septal Defect)
3.	Tetralogy of Fallot (Fallot Tetralogy)
4.	Pulmonary Atresia (Pulmonary Valve Atresia)
5.	Tricuspid Atresia
35 Diseases and 65 more articles analyzed in the Research Interface, order at left...

Experts

1.	Bernstein, Jonathan: 1 article (07/2008)
2.	Collazos, Juan C: 1 article (07/2008)
3.	Ciccolo, Michael L: 1 article (07/2008)
4.	Evans, William N: 1 article (07/2008)
5.	Winters, James M: 1 article (07/2008)
6.	Krueger, Justin: 1 article (07/2008)
7.	Restrepo, Humberto: 1 article (07/2008)
8.	Acherman, Ruben J: 1 article (07/2008)
9.	Kamata, Kotoe: 1 article (01/2006)
10.	Nagata, Osamu: 1 article (01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Double Outlet Right Ventricle:

1.	Staphylococcal Protein A (A, Protein)IBA 07/01/2003 - "We report a 17-year-old boy with double-outlet right ventricle, atrioventricular septal defect, pulmonary stenosis, and persistent left superior vena cava who developed a protein-losing enteropathy, which was cured by coil embolization of the left azygos vein, thereby interrupting the vein-to-vein shunt." Get all the results and reference details, order at left...
2.	tranilast (N 5')IBA 01/01/1984 - "Complicated" VSD in terms of muscular/multiple (n = 6), subaortic type of double-outlet right ventricle (n = 5), AV-canal type (n = 2) and straddling chordae (n = 2) was present in 15 cases" 02/01/1994 - "Associated cardiac lesions included double-inlet left ventricle anatomy (n = 5), double-outlet right ventricle (n = 4), abnormal aortic valve (n = 5), unbalanced atrioventricular canal (n = 3), and membranous ventricular septal defect (n = 1)" 10/01/1993 - "The primary diagnoses were transposition of the great arteries with ventricular septal defect (n = 10), transposition of the great arteries with intact ventricular septum (n = 5), Taussig-Bing anomaly (n = 4), and atrioventricular and ventriculoarterial discordance (n = 5)" 12/01/2001 - "RESULTS: Nine patients older than 30 days (median age 67 days, range 36 to 108 days) with diagnoses of hypoplastic left heart syndrome (n = 5), double-outlet right ventricle with hypoplastic aortic arch (n = 2), unbalanced atrioventricular septal defect (n = 1), or single left ventricle with subaortic stenosis (n = 1) underwent surgical palliation" 02/01/2000 - "Sixty three patients had other lesions: hypoplastic left ventricle with ventricular septal defect (n = 18), unbalanced complete atrioventricular canal (n = 9), complex double-outlet right ventricle (n = 14), double-inlet left ventricle (n = 11), tricuspid atresia with transposition of the great arteries (n = 6), and others (n = 5), including heterotaxia" Get all the results and reference details, order at left...
3.	Tretinoin (Retinoic Acid)FDA LinkGeneric 05/01/1998 - "In three hearts of the retinoic acid-treated group a morphologic intracardiac anomaly -- a double outlet right ventricle -- was found" 09/01/1995 - "CONCLUSIONS: The present cardiac malformations in the chicken as a result of retinoic acid treatment are part of a continuous spectrum, varying from hearts with an intact ventricular septum and a normal course of the subaortic outflow tract to a double outlet right ventricle with a straddling tricuspid orifice or even a double inlet left ventricle" 09/01/1995 - "BACKGROUND: In a recently developed chick model the teratogen retinoic acid has appeared to induce a spectrum of double outlet right ventricle, which needs further detailed evaluation" 09/01/1995 - "To obtain insight into the hemodynamics of abnormal cardiac development, a chick embryo model was recently developed in which a spectrum of double outlet right ventricle was induced with all-trans-retinoic acid" 05/01/1995 - "In experiment 1, among 45 embryos treated with retinoic acid 70 mg/kg at day 8.5 of gestation, 35 (78%) had TGA and 3 (6.7%) had a double-outlet right ventricle with a subpulmonary ventricular septal defect" Get all the results and reference details, order at left...
4.	Myosin Type IIIBA 11/11/1997 - "These studies suggest that nonmuscle myosin II-B is required for normal cardiac myocyte development and that its absence results in structural defects resembling, in part, two common human congenital heart diseases, tetralogy of Fallot and double outlet right ventricle." Get all the results and reference details, order at left...
5.	AntibodiesIBA 12/01/2005 - "METHODS: We used an animal model of retinoic acid (RA)-evoked outflow tract malformations (e.g., double outlet right ventricle [DORV], transposition of the great arteries [TGA], and common truncus arteriosus [CTA]) to study the embryogenesis of coronary arteries using endothelial cell markers (anti-PECAM-1 antibodies and Griffonia simplicifolia I (GSI) lectin)" Get all the results and reference details, order at left...
6.	Polyethylene Terephthalates (Polyethylene Terephthalate)IBA 09/01/1975 - "Subsequently a transverse right ventriculotomy, either alone or combined with a right ventricular outflow and/or pulmonary artery patch enlargement was performed in 16 patients, and a double outlet right ventricle was created through insertion of a Dacron tube graft in two patients" 02/01/1976 - "A 41/2-year-old child developed a severe degree of intravascular hemolysis within 24 hours after intraventricular correction of double-outlet right ventricle with a Dacron patch" 06/01/1990 - "The hypoplastic left ventricle of an 11-year-old girl with complex double-outlet right ventricle was successfully incorporated in a modified biventricular repair by Dacron patch closure of the ventricular septal defect, diversion of venous return of the inferior vena cava to the mitral valve with an intraatrial baffle, insertion of a left ventricular apex to pulmonary artery valved aortic homograft, and diversion of residual systemic venous return directly to the lungs with a bidirectional superior vena cava to pulmonary artery shunt" 10/01/1976 - "In a case of double outlet right ventricle with d-transposition and atrioventricular concordance and a subvalvular pulmonary stenosis an intraventricular conduit with a 16 mm Dacron vascular prosthesis was used" 02/01/2000 - "Seventeen years after corrective surgery for a double outlet right ventricle and pulmonary stenosis, a 30-year-old patient was admitted for reoperation for a critical stenosis of a porcine-valved Dacron conduit between the right ventricle and pulmonary artery" Get all the results and reference details, order at left...
7.	OxygenIBA 07/01/1976 - "Thus, pulmonary arterial oxygen saturation greater than systemic arterial saturation is not reliable evidence of a Taussig-Bing anomaly" 06/01/2007 - "We report on a newborn infant with complex congenital heart disease (CHD) featuring double outlet right ventricle and hypoplastic left ventricle who had postductal oxygen saturation well above 95% and thus eluded pulse oximetry screening for CHD." 11/01/1976 - "Criteria for selection of patients with transposition of the great arteries of double outlet right ventricle who would benefit from a palliative Mustard procedure (Mustard atrial baffle without closure of the ventricular spetal defect) are: 1) severe symptoms; 2) pulmonary arteiral hypertension (75% systemic) with pulmonary vascular obstructive disease; and 3) pulmonary artieral oxygen saturation greater than systemic (ascending aorta) arterial oxygen saturation by approximately 10%." 01/01/1991 - "Cardiac catheterization in Case 1 revealed normal pulmonary artery pressure, severe subvalvular pulmonic stenosis, a double outlet right ventricle, a significant oxygen step-up at the atrial level and moderate systemic oxygen desaturation; while Case 2 disclosed pulmonary hypertension and mild systemic oxygen desaturation" 08/01/1989 - "The cardiac defects that best responded to PGE1 were pulmonary atresia with or without ventricular septal defect, Ebstein's anomaly, tricuspid atresia, pulmonic stenosis, double outlet right ventricle, and those that the arterial oxygen saturation increase was less than 10 vol" Get all the results and reference details, order at left...
8.	Fumigant 93 (D-D)IBA 02/01/1993 - "Patient 2 had visceroatrial situs solitus (S), ventricular D-loop (D), and double-outlet right ventricle with a rightward aortic valve (D), or (S,D,D) segmental set (AV situs concordance)" 07/01/1977 - "Double-outlet right ventricle (S,D,D), VSD related to pulmonary artery, and pulmonic stenosis absent" 01/01/1986 - "A case of successful repair of double outlet right ventricle with atrio-ventricular discordance (I.D.D.), tricuspid regurgitation and pulmonary stenosis]" 07/01/1977 - "The case history of a 5-month-old infant with double-outlet right ventricle (S,D,D) ventricular septal defect (VSD) related to the pulmonary artery, and absence of pulmonic stenosis is reported" 03/01/1977 - "A 3-year-old boy underwent successful surgical correction of double-outlet right ventricle (S, D, D), noncommitted ventricular septal defect (VSD) of the endocardial cushion type, and pulmonary stenosis" Get all the results and reference details, order at left...
9.	Coenzyme A (CoA)IBA 06/01/1994 - "Group IB had 3 cases which included VSD with CoA, Taussig-Bing anomaly, and common atrioventricular canal with VSD" 07/01/1999 - "The malformations in order of frequency were: ventricular septal defect (VSD) (28%), atrioventricular septal defect (AVSD) (16%), hypoplastic left heart (HLH) (16%), double outlet right ventricle (DORV) (12%), coarctation of the aorta (CoA) (6%), transposition of the great arteries (TGA) (4%), aortic valve stenosis (AoVS) (4%), tetralogy of Fallot (TOF) (3%), truncus arteriosus communis (TAC) (3%), pulmonary valve stenosis/pulmonary valve atresia (PaVS/PaVA) (3%), tricuspid atresia (TA) (3%), single ventricle (SV) (1.5%), and atrial septal defect (ASD) (0.5%)" 06/01/2003 - "Primary diagnoses included variant of single ventricle (8), ventricular septal defect (VSD) (4), tetralogy of Fallot (TOF) (2), pulmonary atresia (PA) with VSD (3), simple transposition of the great arteries (TGA) (1), TGA with VSD (TGA/VSD) (2), atrioventricular canal (AVC) (4), double outlet right ventricle (DORV) (3), aortic coarctation (CoA) (2), and interrupted aortic arch with VSD (IAA/VSD) (3)" Get all the results and reference details, order at left...
10.	CAV protocol (CHO)FDA Link 01/01/1986 - "This type of mitral valve in AVC may also be associated with double outlet right ventricle" 01/01/1986 - "Except for one case with double outlet right ventricle and AVC, in the other five cases AVC occurred with normally related great vessels" 05/01/2001 - "Common heart defects were aortic atresia (n = 8), mitral atresia and double-outlet right ventricle (n = 5), and unbalanced AVC (n = 5)" 06/01/2003 - "Primary diagnoses included variant of single ventricle (8), ventricular septal defect (VSD) (4), tetralogy of Fallot (TOF) (2), pulmonary atresia (PA) with VSD (3), simple transposition of the great arteries (TGA) (1), TGA with VSD (TGA/VSD) (2), atrioventricular canal (AVC) (4), double outlet right ventricle (DORV) (3), aortic coarctation (CoA) (2), and interrupted aortic arch with VSD (IAA/VSD) (3)" Get all the results and reference details, order at left...
31 Drugs and Important Bio-Agents and 61 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass) 12/01/2003 - "Cardiopulmonary bypass was not needed in any patient for placement of the device and needed in 4 patients for repair of concomitant malformations only (double-outlet right ventricle, aortic arch hypoplasia, pulmonary artery band removal)" 03/01/2005 - "Cardiopulmonary bypass was needed only for repair of concomitant lesions, such as double-outlet right ventricle, aortic coarctation, or pulmonary artery band removal" 10/01/1976 - "We describe a case of double outlet right ventricle with subaortic ventricular septal defect and pulmonary stenosis treated successfully with cardiopulmonary bypass" 03/01/1981 - "An 18-year-old Japanese girl with double-outlet right ventricle (DORV) [S,D,L], subaortic ventricular septal defect and pulmonary stenosis was successfully treated under cardiopulmonary bypass by resection of the obstructing subpulmonic infundibulum, pulmonary valvulotomy and construction of an intraventricular conduit between the ventricular septal defect and the aorta" 07/01/2008 - "We report the use of the anticoagulant argatroban for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of HIT." Get all the results and reference details, order at left...
2.	Fontan Procedure (Fontan Operation) 04/01/2008 - "The second patient (an 11-month-old boy, 6.4 kg), with a double outlet right ventricle, was scheduled for a hemi-Fontan procedure" 01/01/2002 - "We describe a 25-year-old woman who had a successful pregnancy after the repair of a double outlet right ventricle using the Fontan procedure" 01/01/2002 - "Pregnancy after undergoing the Fontan procedure for a double outlet right ventricle: report of a case." 11/01/2001 - "CONCLUSIONS: Survival was high for all patients with double outlet right ventricle undergoing intraventricular tunnel repair, arterial switch operation, and repair with a conduit or a modified Fontan procedure" 02/01/1990 - "A case of modified Fontan operation for complete atrioventricular canal of right dominance with double-outlet right ventricle, common atrioventricular valve regurgitation]" Get all the results and reference details, order at left...
3.	Homologous Transplantation (Allograft) 06/01/1997 - "Echocardiography of the right ventricle-to-pulmonary artery homograft conduit of patients with transposition of the great arteries or double outlet right ventricle undergoing the Rastelli procedure." 02/01/1979 - "Use of an aortic homograft for surgical correction of a double-outlet right ventricle in a kitten." 12/01/1973 - "Long-term fate of homograft ascending aorta with valve, utilized for reconstruction of the pulmonary artery in double outlet right ventricle with ventricular inversion." 02/01/2004 - "We present the clinical case of a 14-year-old child with complex congenital heart disease (double outlet right ventricle) who underwent two corrective surgeries (Rastelli operation and subsequent replacement of the homograft in the conduit connecting the right ventricle to the pulmonary artery; ventricular septal defect closure and tricuspid valve repair)" 06/01/1997 - "METHODS: Since 1995, 12 patients ranging in age from 3 to 22 years, with transposition of the great arteries or double outlet right ventricle associated with pulmonary stenosis and ventricular septal defect, underwent the Rastelli procedure with the RVOT reconstruction utilizing cryopreserved aortic valved homograft conduits" Get all the results and reference details, order at left...
4.	Right Heart Bypass (Cavopulmonary Anastomosis) 02/01/2003 - "A very rare case of double outlet right ventricle with intact ventricular septum and unrestricted pulmonary flow was successfully palliated with pulmonary banding and delayed bidirectional cavopulmonary anastomosis and mitral avulsion" 01/01/2003 - "An 8-month-old boy with double outlet right ventricle with hypoplastic left ventricle, heterotaxy, left atrial isomerism, bilateral superior vena cavae without bridging vein, and interruption of the inferior vena cava with azygous continuation to the left superior cava underwent a bilateral bidirectional cavopulmonary anastomosis" 08/01/1998 - "Clinical Experience: A two-year-old boy with double outlet right ventricle, underwent right heart bypass procedure" 07/01/1994 - "Valvuloplasty for common atrioventricular valvular regurgitation and bidirectional cavopulmonary shunt were successfully performed in 3 children with univentricular heart and double-outlet right ventricle" 12/01/2000 - "We performed the definitive operation for six patients with coarctation with ventricular septal defect and two patients with double outlet right ventricle, and we performed a bidirectional cavopulmonary shunt for four univentricular hearts who are candidates for the Fontan operation" Get all the results and reference details, order at left...
5.	Transplants (Transplant) 07/01/2005 - "We report a case of congenital ascending aortic aneurysm associated with double-outlet right ventricle that has been successfully repaired by graft replacement and extracardiac total cavo-pulmonary connection." 09/01/1975 - "Subsequently a transverse right ventriculotomy, either alone or combined with a right ventricular outflow and/or pulmonary artery patch enlargement was performed in 16 patients, and a double outlet right ventricle was created through insertion of a Dacron tube graft in two patients" 07/01/1992 - "The diagnosis was transposition of the great arteries with ventricular septal defect and left ventricular outflow tract obstruction in 51, truncus arteriosus in 36, pulmonary atresia with ventricular septal defect in 25, tetralogy of Fallot in 19, double-outlet right ventricle in 10, pulmonary atresia with intact ventricular septum in 6 and atrioventricular canal with pulmonary atresia in 1. A Dacron porcine-valved conduit was used in 37, a homograft conduit in 106 and a nonvalved conduit in 5. There were 13 early deaths overall (8.8%); 8 (22%) of the early deaths occurred in the 37 patients who received a Dacron graft, 4 (3.8%) occurred in the 106 patients who received a homograft and 1 occurred in a patient with a nonvalved Gore-Tex conduit" Get all the results and reference details, order at left...
18 Therapies and Procedures and 45 more articles analyzed in the Research Interface, order at left...

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