|1.||Kurup, Ravi Kumar: 15 articles (12/2003 - 06/2002)|
|2.||Kurup, Parameswara Achutha: 15 articles (11/2003 - 06/2002)|
|3.||Lehle, Ludwig: 6 articles (11/2010 - 06/2003)|
|4.||Kurup, P A: 6 articles (12/2001 - 09/2000)|
|5.||Körner, Christian: 4 articles (11/2010 - 06/2003)|
|6.||Lefeber, Dirk J: 3 articles (08/2011 - 07/2009)|
|7.||Thiel, Christian: 3 articles (04/2010 - 06/2003)|
|8.||Wen, Rong: 2 articles (09/2014 - 12/2013)|
|9.||Guan, Ziqiang: 2 articles (09/2014 - 12/2013)|
|10.||Gao, Ningguo: 2 articles (02/2012 - 01/2006)|
01/01/1995 - "The present data raise the possibility that PDGF or related factors, through autocrine loops, may contribute to the maintenance of a high dolichol synthesis in tumor cells."
06/01/1990 - "The dolichol fraction from hepatomas with a low degree of differentiation contained higher relative amounts of short polyisoprenols (D17) and slightly lower relative amounts of D21 compared with healthy liver tissue, metastatic liver tumors or hepatomas with a high degree of differentiation. "
01/01/2001 - "Concurrent use of agents that inhibit dolichol synthesis can be expected to prevent an increase in plasma membrane IGF-I receptors, thus potentiating the cancer-retardant efficacy of IGF-I down-regulation. "
02/01/1984 - "Dolichol-mediated protein glycosylation exhibited a general decrease in the microsomes from nodules and cancer tissue; it is suggested that the main cause of the decrease is a shortage of the available dolichyl phosphate which is rate limiting and which also contributes to the synthesis of the modified oligosaccharide chain."
11/01/2000 - "Dolichol concentrations were significantly lower in papillary cancer (0.4 micromol/g) and Basedow disease (0.3 micromol/g) compared to normal thyroid (p < 0.01 and p < 0.05, respectively), while cholesterol was enhanced only in cancer tissue (10.7 micromol/g). "
|2.||Liver Cirrhosis (Hepatic Cirrhosis)
05/16/1983 - "A drastic increase in dolichol content was observed in rat liver hyperplastic nodules while human liver cirrhosis and hepatocarcinoma showed a marked decrease in dolichol. "
01/01/2005 - "Our line of researches follows the hypothesis that dolichol and retinol metabolism might be interrelated and involved in liver fibrosis. "
09/29/2000 - "We studied dolichol, on account of its role in membrane fluidity and fusion, and retinol, on account of its behaviour in liver fibrosis, in isolated parenchymal and sinusoidal rat liver cells after CCl4 treatment for 3, 5 and 7 weeks. "
01/01/2003 - "The following parameters were measured in patients with (i) acid peptic disease, (ii) ulcerative colitis, (iii) gallstones, (iv) cryptogenic cirrhosis liver, (v) Reye's syndrome, (vi) mesenteric artery occlusion, (vii) irritable bowel syndrome, and (viii) in individuals with right hemispheric, left hemispheric, and bihemispheric dominance: 1. plasma HMG CoA reductase, digoxin, dolichol, ubiquinone, and magnesium levels; 2. tryptophan/tyrosine catabolic patterns; 3. free radical metabolism; 4. glycoconjugate metabolism; and 5. membrane composition. "
12/01/2003 - "Hyperdigoxinemia-related altered intracellular Ca++/Mg++ ratios mediated oncogene activation, dolichol-induced altered glycoconjugate metabolism, and ubiquinone deficiency-related mitochondrial dysfunction can contribute to the pathogenesis of multiple myeloma. "
01/01/2003 - "Hyperdigoxinemia related altered intracellular Ca++ mediated oncogene activation, dolichol induced altered glycoconjugate metabolism and ubiquinone deficiency related mitochondrial dysfunction can contribute to the pathogenesis of multiple myeloma. "
12/01/2003 - "This study assessed the changes in the isoprenoid pathway and its metabolites digoxin, dolichol, and ubiquinone in multiple myeloma. "
01/01/2003 - "This study assessed the changes in the isoprenoid pathway and its metabolites digoxin, dolichol and ubiquinone in multiple myeloma. "
|4.||Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders)
03/01/2004 - "This study describes the discovery of a new inherited disorder of glycosylation named "CDG-Ik." CDG-Ik (congenital disorder of glycoslyation type Ik) is based on a defect of human mannosyltransferase I (MT-I [MIM 605907]), an enzyme necessary for the elongation of dolichol-linked chitobiose during N-glycan biosynthesis. "
09/02/2014 - "Moreover, we describe a family with a congenital disorder of glycosylation caused by a loss of function mutation in the conserved C terminus of NgBR-R290H and show that fibroblasts isolated from patients exhibit reduced dolichol profiles and enhanced accumulation of free cholesterol identically to fibroblasts from mice lacking NgBR. "
03/01/2004 - "Deficiency of GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase causes congenital disorder of glycosylation type Ik."
01/01/2000 - "Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie."
08/01/2003 - "Deficiency of UDP-GlcNAc:Dolichol Phosphate N-Acetylglucosamine-1 Phosphate Transferase (DPAGT1) causes a novel congenital disorder of Glycosylation Type Ij."
|5.||Alcoholism (Alcohol Abuse)
08/01/1990 - "Brain and liver dolichol in chronic alcoholism: a necropsy study."
12/01/1991 - "Urinary dolichol--a doubtful marker of alcoholism."
08/01/1990 - "Cerebral gray and white matter and liver dolichol levels were measured in postmortem samples from chronic alcoholics and nonalcoholic controls following recent suggestions that dolichol levels may be used as a marker for alcoholism. "
08/01/1989 - "During detoxification treatment of 12 alcoholics, mean serum dolichol concentration stayed constant for the first 7 days; on entering treatment it was 227.7 +/- 15.0 ng/ml, on the 3rd day 238.5 +/- 15.9 ng/ml, and on the 7th day of treatment 222.6 +/- 18.6 ng/ml. Our results show that as well as increasing urinary dolichol excretion, chronic alcohol abuse also produces increased serum dolichol concentrations. "
12/01/1987 - "Urinary dolichol is suggested as a potential tool for the detection and follow-up of alcohol abuse."
|2.||Insulin-Like Growth Factor I (IGF-1)
|5.||Proteins (Proteins, Gene)