Dolichols

A class of polyprenols which contain approximately 20 isoprene residues. Although considered ISOPRENOIDS, they terminate with an alpha-saturated isoprenoid group at the hydroxy end of the molecule.

Also Known As:

Eicosamethyl Octacontanonadecasen 1 ol; Octacontanonadecasen-1-ol, Eicosamethyl; 6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70,74,78-Octacontanonadecaen-1-ol, 3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75,79-eicosamethyl-; Dolichol; Eicosamethyl Octacontanonadecasen-1-ol

Networked: 187 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kurup, Parameswara Achutha: 16 articles (06/2004 - 06/2002)
2.	Kurup, Ravi Kumar: 15 articles (12/2003 - 06/2002)
3.	Swiezewska, Ewa: 6 articles (06/2020 - 01/2002)
4.	Lehle, Ludwig: 6 articles (11/2010 - 06/2003)
5.	Kurup, P A: 6 articles (12/2001 - 09/2000)
6.	Lefeber, Dirk J: 5 articles (01/2022 - 07/2009)
7.	Thiel, Christian: 4 articles (11/2019 - 06/2003)
8.	Körner, Christian: 4 articles (11/2010 - 06/2003)
9.	Grabińska, Kariona A: 3 articles (01/2022 - 09/2014)
10.	Sessa, William C: 3 articles (01/2022 - 09/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1995 - "The present data raise the possibility that PDGF or related factors, through autocrine loops, may contribute to the maintenance of a high dolichol synthesis in tumor cells." 09/15/1991 - "The dolichols made in cultured non-tumorigenic cells, freshly isolated mononuclear leucocytes from a normal individual or a patient with non-haematological malignancy had normal chain length." 02/01/1989 - "Significant increases in urinary dolichol levels in bacterial infections, malignancies and pregnancy but not in other clinical conditions." 01/01/2001 - "Concurrent use of agents that inhibit dolichol synthesis can be expected to prevent an increase in plasma membrane IGF-I receptors, thus potentiating the cancer-retardant efficacy of IGF-I down-regulation. " 01/01/2016 - "These findings provide experimental evidence for usage of simvastatin in novel chemotherapeutic regimens and link dolichol depletion to simvastatin-induced anti-cancer activity. "
2.	Liver Cirrhosis (Hepatic Cirrhosis) 05/16/1983 - "A drastic increase in dolichol content was observed in rat liver hyperplastic nodules while human liver cirrhosis and hepatocarcinoma showed a marked decrease in dolichol. " 01/01/2005 - "Our line of researches follows the hypothesis that dolichol and retinol metabolism might be interrelated and involved in liver fibrosis. " 09/29/2000 - "We studied dolichol, on account of its role in membrane fluidity and fusion, and retinol, on account of its behaviour in liver fibrosis, in isolated parenchymal and sinusoidal rat liver cells after CCl4 treatment for 3, 5 and 7 weeks. "
3.	Alcoholism (Alcohol Abuse) 08/01/1990 - "Brain and liver dolichol in chronic alcoholism: a necropsy study." 12/01/1991 - "Urinary dolichol--a doubtful marker of alcoholism." 08/01/1990 - "Cerebral gray and white matter and liver dolichol levels were measured in postmortem samples from chronic alcoholics and nonalcoholic controls following recent suggestions that dolichol levels may be used as a marker for alcoholism. " 08/01/1989 - "During detoxification treatment of 12 alcoholics, mean serum dolichol concentration stayed constant for the first 7 days; on entering treatment it was 227.7 +/- 15.0 ng/ml, on the 3rd day 238.5 +/- 15.9 ng/ml, and on the 7th day of treatment 222.6 +/- 18.6 ng/ml. Our results show that as well as increasing urinary dolichol excretion, chronic alcohol abuse also produces increased serum dolichol concentrations. " 12/01/1987 - "Urinary dolichol is suggested as a potential tool for the detection and follow-up of alcohol abuse."
4.	Multiple Myeloma 12/01/2003 - "Hyperdigoxinemia-related altered intracellular Ca++/Mg++ ratios mediated oncogene activation, dolichol-induced altered glycoconjugate metabolism, and ubiquinone deficiency-related mitochondrial dysfunction can contribute to the pathogenesis of multiple myeloma. " 01/01/2003 - "Hyperdigoxinemia related altered intracellular Ca++ mediated oncogene activation, dolichol induced altered glycoconjugate metabolism and ubiquinone deficiency related mitochondrial dysfunction can contribute to the pathogenesis of multiple myeloma. " 12/01/2003 - "This study assessed the changes in the isoprenoid pathway and its metabolites digoxin, dolichol, and ubiquinone in multiple myeloma. " 01/01/2003 - "This study assessed the changes in the isoprenoid pathway and its metabolites digoxin, dolichol and ubiquinone in multiple myeloma. "
5.	Carcinogenesis 01/01/1982 - "Dolichol metabolism requires the cooperative action of several intracellular organelles and disturbance in the metabolism is one of the factors behind changes in glycosylation reactions during chemical carcinogenesis. " 10/17/1987 - "Time course of dolichol and dolichyl phosphate during chemical carcinogenesis in rat liver." 04/25/2022 - "Previous studies have revealed that NgBR is involved in a variety of physiological and pathophysiological processes, such as dolichol synthesis, lipid metabolism, cholesterol trafficking, insulin resistance, vascular remodeling and angiogenesis, tumorigenesis and nervous system diseases. " 01/01/2020 - "Notably, its specific receptor, Nogo-B receptor (NgBR), encoded by NUS1, has been implicated in many crucial cellular processes, such as cholesterol trafficking, lipid metabolism, dolichol synthesis, protein N-glycosylation, vascular remodelling, angiogenesis, tumorigenesis and neurodevelopment. " 06/01/2002 - "Alteration in the isoprenoid metabolites--digoxin, ubiquinone, and dolichol--have been reported in neuronal degeneration (Parkinson's disease), oncogenesis (central nervous system glioma), functional neuropsychiatric disorders (schizophrenia and epilepsy), and immune-mediated disorders (multiple sclerosis). "

Related Drugs and Biologics

1.	Terpenes (Terpenoids)
2.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
3.	Insulin-Like Growth Factor I (IGF-1)
4.	Digoxin (Digitek)
5.	Ubiquinone
6.	Proteins (Proteins, Gene)
7.	Biomarkers (Surrogate Marker)
8.	Cholesterol
9.	Lipids
10.	Mannosyltransferases

Related Therapies and Procedures

1.	Caloric Restriction
2.	Lenses