Superhelical DNA (Supercoiled DNA)

Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.
Also Known As:
Supercoiled DNA; DNA, Superhelical; Supertwisted DNA; DNA, Supercoiled; DNA, Supertwisted
Networked: 53 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results


1. Iamshanov, V A: 1 article (05/2013)
2. Kovan'ko, E G: 1 article (05/2013)
3. Mikhelson, V M: 1 article (05/2013)
4. Ivanov, S D: 1 article (05/2013)
5. Semenov, A L: 1 article (05/2013)
6. Volkova, Margarita V: 1 article (07/2012)
7. Senkovich, Sergey A: 1 article (07/2012)
8. Nevinsky, Georgy A: 1 article (07/2012)
9. Parkhomenko, Taisiya A: 1 article (07/2012)
10. Buneva, Valentina N: 1 article (07/2012)

Related Diseases

1. Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell)
2. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
3. Neoplasms (Cancer)
4. Infection
5. Leukemia
02/26/2003 - "indica was found to possess significant free radical scavenging activity, effectively protecting phix174 supercoiled DNA against strand cleavage and reducing oxidative stress in human promyelocytic leukemia HL-60 cells. "
07/01/2001 - "Furthermore, the heartwood extract protected PhiX174 supercoiled DNA against strand scission induced by ultraviolet photolysis of H2O2, and it reduced the amounts of intracellular hydrogen peroxide, a reactive oxygen species, when it was co-incubated with human promyelocytic leukemia (HL-60) cells under oxidative stress."
03/13/2000 - "Furthermore, the extract protected against strand scission in phiX174 supercoiled DNA induced by UV photolysis of H2O2, and was also capable of scavenging superoxide generated by xanthine-xanthine oxidase or by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocytic leukemia (HL-60) cells. "
01/25/2006 - "The copper complex cleaves PhiX174 supercoiled DNA efficiently without any reductant and shows high cytotoxicities toward L1210 murine leukemia and A2780 human ovarian carcinoma cancer cell lines that are sensitive and resistant to cisplatin. "
04/15/2003 - "The strong binding interaction between the drugs and DNA perturbs the relaxation of supercoiled DNA by topoisomerases, but the test compounds do not promote DNA cleavage by topoisomerase I or II. Despite the lack of poisoning effect toward topoisomerase II, MCI3335 displays a very high cytotoxicity toward CEM human leukemia cells, with an IC(50) in the low nanomolar range, approximately 4 times inferior to that of the reference drug elinafide. "

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. Type II DNA Topoisomerases (Topoisomerase II)
3. Kinetoplast DNA (kDNA)
4. Type I DNA Topoisomerases (Topoisomerase I)
5. Adenosine Triphosphate (ATP)
6. A-Form DNA (A-DNA)
7. trioctyl phosphine oxide (TOPO)
8. Coordination Complexes
9. DNA-(Apurinic or Apyrimidinic Site) Lyase (AP Endonuclease)
10. Xanthine