|1.||Iamshanov, V A: 1 article (05/2013)|
|2.||Kovan'ko, E G: 1 article (05/2013)|
|3.||Mikhelson, V M: 1 article (05/2013)|
|4.||Ivanov, S D: 1 article (05/2013)|
|5.||Semenov, A L: 1 article (05/2013)|
|6.||Volkova, Margarita V: 1 article (07/2012)|
|7.||Senkovich, Sergey A: 1 article (07/2012)|
|8.||Nevinsky, Georgy A: 1 article (07/2012)|
|9.||Parkhomenko, Taisiya A: 1 article (07/2012)|
|10.||Buneva, Valentina N: 1 article (07/2012)|
|1.||Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell)
01/01/1998 - "In the present study, we present evidence suggesting that the molecular basis for the anti-proliferative activity of these drugs is the inhibition of topoisomerase II. The NBQ-2 derivatives inhibited the relaxation of supercoiled DNA plasmid pRYG mediated by purified human topoisomerase II. Inhibition of the decatenation of kinetoplast DNA mediated by partially purified topoisomerase II extracted from the human histiocytic lymphoma U937 (a cell line previously shown to be sensitive to the drugs) was also caused by these drugs. "
|2.||BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
05/01/2013 - "The mineral water administration before irradiation resulted in the reduction of the supercoiled DNA index on the 1st and 21st day after irradiation, as well as in monocytopeny and a definite decrease in the tumor volume on the 21st day of the experiment as compared with control, which is associated with the ferroptosis effect of ICW. "
11/15/2002 - "Role of tumor suppressor p53 domains in selective binding to supercoiled DNA."
09/17/1999 - "Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain."
08/01/1991 - "Interaction between ionizing radiation and supercoiled DNA within human tumor cells."
04/01/1982 - "Avian tumor virus supercoiled DNA was isolated from infected quail tumor cells and molecularly cloned in pBR322. "
06/01/2001 - "For the outcome of a hepatitis B virus (HBV) infection, the viral L envelope protein with its pre-S domain performs pivotal functions by mediating attachment of HBV to liver cells, envelopment of viral capsids, release of (sub)viral particles, regulation of supercoiled DNA amplification, and transcriptional transactivation. "
01/01/1980 - "Cleavage of superhelical DNA from a lambda pi B mutant phage was observed after infection of either strain whereas superhelical DNA from a wild type phage was only cleaved after infection of JG28. "
01/01/1979 - "Infectious supercoiled DNA could be recovered from 16 h after infection. "
01/01/2000 - "Amajor reason for treatment failure during antiviral therapy of chronic hepatitis B infection is thought to be the persistence of the key replicative intermediate, the viral covalently closed circular (CCC) or supercoiled DNA (1,2). "
08/15/2006 - "The results indicate that the acridine analogs bearing substituted carboxamides and bulky 9-amino functionalities are able to inhibit herpes infections as well as inhibit topoisomerase II relaxation of supercoiled DNA. "
02/26/2003 - "indica was found to possess significant free radical scavenging activity, effectively protecting phix174 supercoiled DNA against strand cleavage and reducing oxidative stress in human promyelocytic leukemia HL-60 cells. "
07/01/2001 - "Furthermore, the heartwood extract protected PhiX174 supercoiled DNA against strand scission induced by ultraviolet photolysis of H2O2, and it reduced the amounts of intracellular hydrogen peroxide, a reactive oxygen species, when it was co-incubated with human promyelocytic leukemia (HL-60) cells under oxidative stress."
03/13/2000 - "Furthermore, the extract protected against strand scission in phiX174 supercoiled DNA induced by UV photolysis of H2O2, and was also capable of scavenging superoxide generated by xanthine-xanthine oxidase or by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocytic leukemia (HL-60) cells. "
01/25/2006 - "The copper complex cleaves PhiX174 supercoiled DNA efficiently without any reductant and shows high cytotoxicities toward L1210 murine leukemia and A2780 human ovarian carcinoma cancer cell lines that are sensitive and resistant to cisplatin. "
04/15/2003 - "The strong binding interaction between the drugs and DNA perturbs the relaxation of supercoiled DNA by topoisomerases, but the test compounds do not promote DNA cleavage by topoisomerase I or II. Despite the lack of poisoning effect toward topoisomerase II, MCI3335 displays a very high cytotoxicity toward CEM human leukemia cells, with an IC(50) in the low nanomolar range, approximately 4 times inferior to that of the reference drug elinafide. "
|1.||DNA (Deoxyribonucleic Acid)
|2.||Type II DNA Topoisomerases (Topoisomerase II)
|3.||Kinetoplast DNA (kDNA)
|4.||Type I DNA Topoisomerases (Topoisomerase I)
|5.||Adenosine Triphosphate (ATP)
|6.||A-Form DNA (A-DNA)
|7.||trioctyl phosphine oxide (TOPO)
|9.||DNA-(Apurinic or Apyrimidinic Site) Lyase (AP Endonuclease)