|1.||Trojanowski, John Q: 46 articles (12/2015 - 07/2007)|
|2.||Dickson, Dennis W: 30 articles (11/2015 - 05/2007)|
|3.||Lee, Virginia M-Y: 27 articles (12/2015 - 07/2007)|
|4.||Rademakers, Rosa: 26 articles (07/2015 - 10/2007)|
|5.||Hasegawa, Masato: 21 articles (08/2014 - 12/2006)|
|6.||Neumann, Manuela: 20 articles (07/2015 - 02/2007)|
|7.||Arai, Tetsuaki: 20 articles (08/2014 - 12/2006)|
|8.||Van Broeckhoven, Christine: 18 articles (02/2015 - 08/2009)|
|9.||Akiyama, Haruhiko: 17 articles (08/2014 - 12/2006)|
|10.||Miller, Bruce L: 16 articles (06/2015 - 06/2008)|
|1.||Frontotemporal Lobar Degeneration (Semantic Dementia)
03/01/2014 - "In cohort 2, the frequency of carriers homozygous for the minor allele was not significantly reduced in patients as compared to controls (OR 0.77, p = 0.079); however, a significant reduction was observed when focusing on those patients with frontotemporal lobar degeneration and TAR DNA-binding protein 43 inclusions (FTLD-TDP; OR 0.26, p < 0.001). "
06/01/2013 - "Laminar distribution of the pathological changes in sporadic frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) proteinopathy: a quantitative study using polynomial curve fitting."
07/26/2011 - "The aim of this study was to compare clinical features and perfusion patterns on SPECT of patients with familial FTLD-TAR DNA binding protein 43 kDa (TDP) and MAPT mutations. "
02/01/2010 - "Studies suggest that frontotemporal lobar degeneration with transactive response DNA-binding protein of 43 kDa (TDP-43) proteinopathy (FTLD-TDP) is heterogeneous with division into four or five subtypes. "
01/01/2009 - "Recent studies showed that TAR DNA-binding protein 43 (TDP-43), encoded by the TARDBP gene, is a major pathological protein in both sporadic and familial frontotemporal lobar degeneration (FTLD). "
|2.||Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/01/2015 - "We have used this technique to study aspects of amyotrophic lateral sclerosis (ALS) by administering AAV encoding the ALS-related gene transactive response DNA binding protein of 43 kDa (TDP-43) to neonatal rats. "
05/01/2014 - "The aim of this study was to investigate whether an increased level of TAR DNA-binding protein 43 (TDP-43) in the cerebrospinal fluid (CSF) could be a biomarker for amyotrophic lateral sclerosis (ALS) and facilitate differential diagnosis of ALS from peripheral motor neuropathy. "
04/01/2009 - "Recent studies identified rare missense mutations in amyotrophic lateral sclerosis (ALS) patients in the TARDBP gene encoding TAR DNA binding protein (TDP)-43, the major protein of the ubiquitinated inclusions (UBIs) found in affected motor neurons (MNs). "
11/23/2015 - "Transactive response DNA-binding protein 43 kD (TDP-43) is an aggregation-prone prion-like domain-containing protein and component of pathological intracellular aggregates found in most amyotrophic lateral sclerosis (ALS) patients. "
08/01/2015 - "Review: Prion-like mechanisms of transactive response DNA binding protein of 43 kDa (TDP-43) in amyotrophic lateral sclerosis (ALS)."
10/01/2014 - "Early in infection, UL84FLAG colocalized with the viral single-stranded DNA binding protein UL57, but colocalization became less prominent as infection progressed. "
01/01/2014 - "[Application of artificial DNA-binding proteins and artificial nucleases to prevention of virus infection: development of virus-resistant plants and protein-based anti-viral drugs]."
02/01/2012 - "The protamine-like DNA-binding protein P6.9 epigenetically up-regulates Autographa californica multiple nucleopolyhedrovirus gene transcription in the late infection phase."
01/01/2010 - "EBNA1 is an EBV-encoded DNA-binding protein required for viral genome maintenance during latent infection. "
05/01/2008 - "The ability of Vpx to counteract the restriction to HIV-1 and SIV infection was dependent upon the HIV-1 Vpr interacting protein, damaged DNA binding protein 1 (DDB1), and DDB1 partially substituted for Vpx when fused to Vpr. "
|4.||Neurodegenerative Diseases (Neurodegenerative Disease)
04/01/2014 - "Accumulation of transactive response DNA binding protein (TDP-43) fragments in motor neurons is a post mortem hallmark of different neurodegenerative diseases. "
01/14/2011 - "TAR DNA-binding protein 43 (TDP-43) is associated with a spectrum of neurodegenerative diseases. "
04/01/2010 - "TAR DNA-binding protein 43 in neurodegenerative disease."
01/01/2010 - "The role of the 43-kDa transactivation-responsive DNA-binding protein (TDP43) in neurodegenerative diseases is not yet clearly established. "
09/15/2015 - "TAR DNA-binding protein 43 (TDP-43) is a major disease protein in amyotrophic lateral sclerosis (ALS) and related neurodegenerative diseases. "
01/01/2015 - "This study demonstrates that human UPF1 exerts protective effects in a rat paralysis model based on the amyotrophic lateral sclerosis (ALS)-associated protein, TDP-43 (transactive response DNA-binding protein 43 kDa). "
09/01/2011 - "Recent transgenic mouse studies have revealed a high degree of toxicity due to transactive response DNA-binding protein 43 proteins when overexpressed under the control of strong neuronal gene promoters, resulting in early paralysis and death, but without the presence of amyotrophic lateral sclerosis-like ubiquitinated transactive response DNA-binding protein 43-positive inclusions. "
|1.||protein TDP-43 (TDP-43)
|2.||DNA (Deoxyribonucleic Acid)
|4.||lenalidomide (CC 5013)
|5.||Proteins (Proteins, Gene)
|7.||HMGB1 Protein (HMG1)
|8.||tau Proteins (tau Protein)
|2.||Heterologous Transplantation (Xenotransplantation)