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Type I DNA Topoisomerases (Topoisomerase I)

DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
Also Known As:
Topoisomerase I; DNA Topoisomerase; DNA Topoisomerases, Type I; DNA Nicking-Closing Proteins; DNA Relaxing Enzymes; DNA Topoisomerase 1, Archaeal; DNA Topoisomerase I, Bacterial; DNA Topoisomerase I, Eukaryotic; DNA Topoisomerases, Type I, Archaeal; DNA Topoisomerases, Type I, Bacterial; DNA Topoisomerases, Type I, Eukaryotic; DNA Type 1 Topoisomerase; DNA Untwisting Enzymes; DNA Untwisting Proteins; Omega Protein, Topoisomerase I; Topoisomerase 1, Archaeal; Topoisomerase I, Bacterial; Topoisomerase I, Eukaryotic; Type I DNA Topoisomerase; Archaeal Topoisomerase 1; Bacterial Topoisomerase I; Eukaryotic Topoisomerase I; DNA Nicking-Closing Protein; DNA Relaxing Enzyme; DNA Relaxing Protein; DNA Topoisomerase I; DNA Untwisting Enzyme; DNA Untwisting Protein
Networked: 1583 relevant articles (77 outcomes, 203 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Pommier, Yves: 43 articles (11/2015 - 01/2002)
2. Lee, Eung-Seok: 14 articles (07/2015 - 07/2007)
3. Kwon, Youngjoo: 13 articles (07/2015 - 01/2010)
4. Cushman, Mark: 13 articles (04/2015 - 01/2002)
5. Bailly, Christian: 13 articles (03/2015 - 11/2002)
6. Karki, Radha: 12 articles (07/2015 - 07/2007)
7. Na, Younghwa: 10 articles (07/2015 - 07/2007)
8. Thapa, Pritam: 10 articles (09/2014 - 07/2007)
9. Sato, Shinichi: 9 articles (05/2014 - 01/2004)
10. Shuman, Stewart: 9 articles (02/2013 - 03/2003)

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
3. Leukemia
4. Ovarian Neoplasms (Ovarian Cancer)
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. irinotecan (Camptosar)
2. Topotecan (Hycamtin)
3. Camptothecin
4. DNA (Deoxyribonucleic Acid)
5. Type II DNA Topoisomerases (Topoisomerase II)
6. Poisons
7. Doxorubicin (Adriamycin)
8. Fluorouracil (Carac)
9. Thymidylate Synthase
10. oxaliplatin (Eloxatin)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)
3. Adjuvant Chemotherapy
4. Combination Drug Therapy (Combination Chemotherapy)
5. Oral Administration