|1.||Pommier, Yves: 43 articles (11/2015 - 01/2002)|
|2.||Lee, Eung-Seok: 14 articles (07/2015 - 07/2007)|
|3.||Kwon, Youngjoo: 13 articles (07/2015 - 01/2010)|
|4.||Cushman, Mark: 13 articles (04/2015 - 01/2002)|
|5.||Bailly, Christian: 13 articles (03/2015 - 11/2002)|
|6.||Karki, Radha: 12 articles (07/2015 - 07/2007)|
|7.||Na, Younghwa: 10 articles (07/2015 - 07/2007)|
|8.||Thapa, Pritam: 10 articles (09/2014 - 07/2007)|
|9.||Sato, Shinichi: 9 articles (05/2014 - 01/2004)|
|10.||Shuman, Stewart: 9 articles (02/2013 - 03/2003)|
11/01/1995 - "These agents are most effective against tumors with high topoisomerase I activity. "
05/01/2009 - "Because camptothecins are effective against previously resistant tumors and are the only class of topoisomerase I (Top1) inhibitors approved for cancer treatment, we developed the indenoisoquinolines. "
01/01/2013 - "Mycoplasma fermentans inhibits the activity of cellular DNA topoisomerase I by activation of PARP1 and alters the efficacy of its anti-cancer inhibitor."
08/18/2014 - "Complex 1 exhibited good anti-tumor activity (GI50 values <10 μg/ml), and to elucidate the mechanism of tumor inhibition, topoisomerase I enzymatic activity was carried out and further validated by cell imaging studies which clearly showed its nuclear localization. "
01/01/2014 - "The strategy used in this study may provide understanding in designing novel DNA topoisomerase IIα inhibitors, as well as for other cancer targets."
|2.||Colorectal Neoplasms (Colorectal Cancer)
01/01/2013 - "Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort."
07/01/2003 - "Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity."
08/01/2000 - "Characterization of the topoisomerase I locus in human colorectal cancer."
01/15/1994 - "By Western blotting, colorectal tumors showed 5-35-fold increases in topoisomerase I levels, compared to their normal colon mucosa. "
01/15/1994 - "In humans, the levels of topoisomerase I have been shown to be elevated in colorectal tumors, compared to normal colon mucosa. "
02/01/1991 - "These results indicate that inhibition of topoisomerase (either topoisomerase I or II) followed by the action of rTNF alpha was effective in inducing differentiation of leukemia cells."
06/17/2011 - "ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line."
01/01/2010 - "Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity."
07/15/2002 - "The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies."
07/01/1999 - "These dimeric analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA), currently in clinical trial, show superior potencies to the corresponding monomeric DACA analogues in a panel of cell lines, including wild-type (JLC) and mutant (JLA and JLD) forms of human Jurkat leukemia. "
|4.||Ovarian Neoplasms (Ovarian Cancer)
05/01/2008 - "The topoisomerase I agents are established as a therapy in recurrent ovarian cancer. "
02/01/2006 - "Hence, providing enhancement in topoisomerase I expression may not result in improvement of CPT response in ovarian cancer cells because of an efficient control of the phosphorylation state of the enzyme."
02/01/2006 - "Taken together, these observations strongly suggest that an alteration in the phosphorylation state of topoisomerase I could limit its activity and prevent improvement of CPT response in ovarian cancer cells. "
02/01/2006 - "Since topoisomerase I has been established as a prime target of these drugs in other experimental models, it was important to determine whether sensitivity to CPTs in ovarian cancer cells is also correlated with the cellular level of this enzyme. "
02/01/2006 - "Altered phosphorylation of topoisomerase I following overexpression in an ovarian cancer cell line."
04/01/2015 - "We have previously published that TAp63 is involved in poly(ADP-ribose)polymerase-1 (PARP-1) signaling of DNA damage deriving from DNA topoisomerase I (TOP I) inhibition in carcinoma cells. "
01/01/2012 - "The association between the p53/topoisomerase I and p53/ topoisomerase IIalpha immunophenotypes and the progression of ovarian carcinomas."
09/01/2008 - "DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity."
05/01/2001 - "Elevations of DNA topoisomerase I in invasive carcinoma of the breast."
04/15/2001 - "RET rearrangements in radiation-induced papillary thyroid carcinomas: high prevalence of topoisomerase I sites at breakpoints and microhomology-mediated end joining in ELE1 and RET chimeric genes."
|4.||DNA (Deoxyribonucleic Acid)
|5.||Type II DNA Topoisomerases (Topoisomerase II)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)
|4.||Combination Drug Therapy (Combination Chemotherapy)