|1.||Mizushina, Yoshiyuki: 10 articles (04/2014 - 10/2003)|
|2.||Yoshida, Hiromi: 7 articles (02/2012 - 10/2003)|
|3.||Sakaguchi, Kengo: 5 articles (05/2005 - 10/2003)|
|4.||Shcherbakova, Polina V: 4 articles (05/2015 - 01/2006)|
|5.||Kuramochi, Kouji: 4 articles (01/2013 - 05/2004)|
|6.||Sugawara, Fumio: 4 articles (02/2012 - 10/2003)|
|7.||Kuriyama, Isoko: 4 articles (02/2012 - 12/2003)|
|8.||Takemura, Masaharu: 4 articles (05/2005 - 06/2002)|
|9.||Pavlov, Youri I: 3 articles (12/2014 - 08/2003)|
|10.||Eckert, Kristin A: 3 articles (07/2014 - 06/2010)|
03/10/2013 - "DNA polymerases, which are involved in the repair of cellular DNA damage, are therefore potential targets for inhibitors for improving the efficacy of cancer therapy. "
06/01/2015 - "Here we examine striking advances that uncover Fe-S cluster roles both in copying the genetic sequence by DNA polymerases and in crucial repair processes for genome maintenance, as mutational defects cause cancer and degenerative disease. "
08/01/2014 - "To potentiate the effect of cancer chemotherapeutic regimens, we sought to identify inhibitors of TLS DNA polymerases. "
09/01/2013 - "We have applied our method to correlate DNA polymerases to cancer phenotypes using four of the available cancer databases in dbGaP. "
03/10/2013 - "Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer."
12/01/1998 - "This hypothesis is supported by the observation of decreased fidelity levels of DNA polymerases in mouse spleen containing tumorigenic cells after infection with Friend virus, and in aged animals that suffer high rates of tumorigenesis. "
10/01/1987 - "Among them, analogues having a vinyl group at the 5-position were strongly active against DNA polymerases induced on herpes virus infection. "
07/01/1978 - "Infection of synchronized bovine fetal spleen cells with bovine parvovirus results in changes in the levels and patterns of DNA polymerases alpha and gamma during the cell cycle. "
01/01/2010 - "While inhibitors of herpesvirus DNA polymerases, like gancyclovir, reduce EBV lytic cycle infection, these treatments have limited efficacy for treating latent infection. "
06/29/2001 - "In this study, we examined whether the biochemical and catalytic properties of SIV DNA polymerases (reverse transcriptases; RT) can change during the course of viral infection. "
|3.||Sarcoma (Soft Tissue Sarcoma)
01/30/1986 - "Mg2+ was also effective with poly(2'-O-methylcytidylate) X oligodeoxyguanylate which was known to be specific for Mn2+. To examine the immunological relatedness of this enzyme with other retroviral DNA polymerases, remaining Sm-MTV DNA polymerase activity was measured after treatment of this enzyme with various antisera prepared against each of the reverse transcriptases of Mason-Pfizer monkey virus (MPMV), murine mammary tumor virus (MuMTV), simian sarcoma virus-simian sarcoma associated virus (SSV/SSAV), and Rauscher murine leukemia virus (RLV). "
12/01/1988 - "A protein factor having exonucleolytic activity on bleomycin-damaged DNA and providing priming sites for DNA polymerases existed in a DNA polymerase beta fraction partially purified by ion exchange chromatography from an extract of permeable mouse ascites sarcoma (SR-C3H/He) cells. "
12/01/1998 - "The fidelity levels of DNA polymerases from Yoshida ascites hepatoma, Rhodamine sarcoma, mouse ascites hepatoma-134, and Ehrlich ascites carcinoma cells derived from rats and mice are very high for in-vitro DNA synthesis on synthetic polynucleotides. "
|4.||Drug Toxicity (Drug Safety)
01/01/2011 - "Our kinetic results suggest NRTI insertion catalyzed by human X- and Y-family DNA polymerases is a potential mechanism of NRTI drug toxicity, and we have established a structure-function relationship for designing improved NRTIs."
01/13/2012 - "However, the usage of these analogues can be limited by drug toxicity because the 5'-triphosphates of these nucleoside analogues (nucleotide analogues) are potential substrates for human DNA polymerases to incorporate into host DNA. "
|5.||Fanconi Anemia (Fanconi's Anemia)
12/01/2012 - "The potential role of Fanconi anemia pathway in the regulation of REV1 and Polζ-dependent TLS and the involvement of additional polymerases, including DNA polymerases kappa, nu, and theta, in the repair of ICLs is also discussed in this review."
01/01/2011 - "These variants were chosen to represent five DNA repair pathways including base excision repair, nucleotide excision repair, double-strand break repair (homologous recombination and non-homologous end-joining), direct reversal repair, and mismatch repair, along with candidate DNA polymerases, Fanconi Anemia complementation groups, and other genes relevant to DNA damage recognition and response. "
06/01/2009 - "In this nested case-control study of 239 prospectively ascertained premenopausal breast cancer cases and 477 matched controls within the Nurses' Health Study II, we evaluated 1,463 genetic variants in 60 candidate genes across five DNA repair pathways, along with DNA polymerases, Fanconi Anemia complementation groups, and other related genes. "
06/01/1977 - "The activities of DNA polymerases alpha, beta, and gamma were determined in control and repair-deficient human fibroblasts (xeroderma pigmentosum complementation groups A, C, and D; Fanconi's Anemia; and Bloom's syndrome). "
06/01/1978 - "Fibroblasts derived from patients with diseases affecting DNA repair processes, such as Xeroderma Pigmentosum (classical and variant), Fanconi's anemia, Bloom's syndrome, Ataxia Telangiectasica, Progeria and Werner's syndrome, were assayed for the three DNA polymerases. "
|1.||DNA (Deoxyribonucleic Acid)
|2.||DNA-Directed RNA Polymerases (RNA Polymerase)
|4.||Immune Sera (Antisera)
|5.||Proteins (Proteins, Gene)
|6.||Proliferating Cell Nuclear Antigen (PCNA)
|7.||RNA-Directed DNA Polymerase (Reverse Transcriptase)
|8.||DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)
|9.||Suramin (Suramin Sodium)
|2.||Drug Therapy (Chemotherapy)
|4.||Transplantation (Transplant Recipients)