DNA Polymerase III

A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II.

Also Known As:

Networked: 68 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Suenaga, Midori: 2 articles (11/2010 - 09/2006)
2.	Hübscher, Ulrich: 2 articles (09/2008 - 02/2002)
3.	Goldsby, Robert E: 2 articles (11/2007 - 11/2002)
4.	Preston, Bradley D: 2 articles (11/2007 - 11/2002)
5.	Burgers, P M: 2 articles (04/2001 - 04/2000)
6.	Godlewski, Janusz: 1 article (05/2022)
7.	Kiezun, Jacek: 1 article (05/2022)
8.	Krazinski, Bartlomiej Emil: 1 article (05/2022)
9.	Stefaniak, Przemyslaw: 1 article (05/2022)
10.	Bains, Kanwal: 1 article (03/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Elevated DNA Polymerase Delta 1 Expression Correlates With Tumor Progression and Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma." 01/01/2010 - "These findings suggest that the DNA polymerase delta catalytic subunit p125 induced by mutant type p53 plays an important role in tumor invasion, which leads to a poorer prognosis in HCC." 11/26/2002 - "High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading." 08/10/2001 - "Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1." 06/01/2001 - "Defective DNA polymerase-delta proofreading causes cancer susceptibility in mice."
2.	Carcinogenesis 11/01/2007 - "Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis." 12/01/2000 - "Based on mutation studies in Saccharomyces cerevisiae lacking Msh2 and DNA polymerase delta (DNA pol delta), we hypothesized that the acquisition of mutations in DNA pol delta could contribute to the hypermutator phenotype and tumorigenesis in Msh2(-/-) thymic tissue. " 01/01/2009 - "These results clearly demonstrate that DNA polymerase delta is essential for mammalian early embryogenesis and that the 3'-5' exonuclease activity of DNA polymerase delta is dispensable for normal development but necessary to suppress tumorigenesis." 11/01/2007 - "Our results indicate that heterozygous mutation at L604 in the polymerase active site of DNA polymerase delta reduces life span, increases genomic instability, and accelerates tumorigenesis in an allele-specific manner, novel findings that have implications for human cancer."
3.	Chromosome Aberrations (Chromosome Abnormalities) 09/01/2008 - "In the study presented here, we show that reduced levels of Pol3p, the catalytic subunit of DNA polymerase delta, induce instability at these same sites and lead to the generation of a variety of chromosomal aberrations. "
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2023 - "In this study, we evaluated the potential of DNA polymerase epsilon (POLE) and DNA polymerase delta 1 (POLD1) as prognostic biomarkers for immune checkpoint inhibitor (ICI) treatment in patients with advanced stage non-small cell lung cancer (NSCLC). "
5.	Genomic Instability 01/01/2023 - "Pol32, an accessory subunit of DNA polymerase delta, plays an essential role in genome stability and pathogenesis of Candida albicans." 01/01/2016 - "The Second Subunit of DNA Polymerase Delta Is Required for Genomic Stability and Epigenetic Regulation." 06/19/2015 - "The activity of eukaryotic DNA polymerase delta (Pol δ) plays an essential role in genome stability through its effects on DNA replication and repair. " 01/01/2010 - "Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells." 09/01/2009 - "Replication stress leads to genome instabilities in Arabidopsis DNA polymerase delta mutants."

Related Drugs and Biologics

1.	DNA Polymerase II
2.	DNA (Deoxyribonucleic Acid)
3.	Biomarkers (Surrogate Marker)
4.	Immune Checkpoint Inhibitors
5.	Proteins (Proteins, Gene)
6.	Proliferating Cell Nuclear Antigen (PCNA)
7.	Holoenzymes
8.	Messenger RNA (mRNA)
9.	Exonucleases (3' 5' Exonuclease)
10.	Flap Endonucleases

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics