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DNA Polymerase II

A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents.
Also Known As:
DNA Pol II; DNA Dependent DNA Polymerase II; DNA Polymerase epsilon; DNA-Dependent DNA Polymerase II
Networked: 69 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. McAlpine, Jessica N: 4 articles (01/2021 - 10/2017)
2. Church, David N: 3 articles (01/2021 - 11/2016)
3. Gilks, C Blake: 3 articles (01/2021 - 10/2017)
4. Huntsman, David G: 3 articles (01/2021 - 10/2017)
5. Collan, Yrjö: 3 articles (05/2010 - 09/2008)
6. Pospiech, Helmut: 3 articles (05/2010 - 09/2008)
7. Zhou, Qi: 3 articles (05/2010 - 09/2008)
8. Huang, Haineng: 2 articles (01/2022 - 01/2021)
9. Liu, Wangrui: 2 articles (01/2022 - 01/2021)
10. Tang, Haijia: 2 articles (01/2022 - 01/2021)

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
3. Microsatellite Instability
4. Uterine Cervical Neoplasms (Cancer of the Cervix)
5. Renal Cell Carcinoma (Grawitz Tumor)

Related Drugs and Biologics

1. Estrogen Receptors
2. Progesterone
3. DNA Polymerase III
4. Immune Checkpoint Inhibitors
5. Biomarkers (Surrogate Marker)
6. Proteins (Proteins, Gene)
7. DNA (Deoxyribonucleic Acid)
8. Phosphodiesterase I (5' Exonuclease)
9. Threonine (L-Threonine)
10. fludarabine phosphate (Fludara)

Related Therapies and Procedures

1. Immunotherapy
2. Therapeutics
3. Cryosurgery