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DNA Polymerase I (Klenow Fragment)

A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.
Also Known As:
Klenow Fragment; Pol I; DNA Dependent DNA Polymerase I; Polymerase I, DNA; Polymerase alpha, DNA; DNA Polymerase alpha; DNA-Dependent DNA Polymerase I
Networked: 276 relevant articles (3 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Rice, William G: 4 articles (07/2012 - 10/2009)
2. Drygin, Denis: 4 articles (07/2012 - 10/2009)
3. Hannan, Ross D: 3 articles (02/2015 - 02/2011)
4. Sanij, Elaine: 3 articles (02/2015 - 02/2011)
5. Laiho, Marikki: 3 articles (11/2014 - 01/2014)
6. Peltonen, Karita: 3 articles (11/2014 - 01/2014)
7. Liu, Hester: 3 articles (11/2014 - 01/2014)
8. Colis, Laureen: 3 articles (11/2014 - 01/2014)
9. Anderes, Kenna: 3 articles (07/2012 - 10/2009)
10. Proffitt, Chris: 3 articles (07/2012 - 10/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Neoplasm Metastasis (Metastasis)
3. Burkitt Lymphoma (Burkitt's Lymphoma)
4. Actinic Keratosis
5. Squamous Cell Carcinoma (Epidermoid Carcinoma)

Related Drugs and Biologics

1. Estrogens (Estrogen)
2. Diphosphates
3. DNA polymerase gamma
4. DNA (Deoxyribonucleic Acid)
5. Bromodeoxyuridine (BrdU)
6. Transferases
7. purine
8. DNA Polymerase beta (DNA Polymerase IV)
9. RNA (Ribonucleic Acid)
10. Proliferating Cell Nuclear Antigen (PCNA)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Hepatectomy
3. Drug Therapy (Chemotherapy)
4. Aftercare (After-Treatment)
5. Therapeutics