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Type II DNA Topoisomerases (Topoisomerase II)

DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
Also Known As:
Topoisomerase II; DNA Topoisomerase (ATP-Hydrolysing); DNA Topoisomerases, Type II; DNA Topoisomerase II, Bacterial; DNA Topoisomerases II, Eukaryotic; DNA Topoisomerases, Type II, Archaeal; DNA Topoisomerases, Type II, Bacterial; DNA Topoisomerases, Type II, Eukaryotic; DNA Type 2 Topoisomerase; Topoisomerase II, Bacterial; Topoisomerases II, Archaeal; Topoisomerases II, Eukaryotic; Type II DNA Topoisomerase; Archaeal Topoisomerases II; Bacterial Topoisomerase II; Eukaryotic Topoisomerases II; DNA Topoisomerase II
Networked: 1248 relevant articles (29 outcomes, 134 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Osheroff, Neil: 17 articles (05/2014 - 01/2003)
2. Felix, Carolyn A: 12 articles (03/2014 - 11/2003)
3. Bailly, Christian: 10 articles (01/2016 - 04/2003)
4. Ding, Jian: 10 articles (04/2015 - 08/2003)
5. Bailly, C: 8 articles (02/2014 - 06/2000)
6. Nitiss, John L: 8 articles (12/2012 - 01/2002)
7. Miao, Ze-Hong: 7 articles (04/2015 - 08/2003)
8. Guilbaud, Nicolas: 6 articles (01/2016 - 12/2008)
9. Li, Tsai-Kun: 6 articles (05/2015 - 04/2003)
10. Hiasa, Hiroshi: 6 articles (08/2012 - 08/2006)

Related Diseases

1. Neoplasms (Cancer)
2. Leukemia
3. Breast Neoplasms (Breast Cancer)
4. Poisoning
5. Small Cell Lung Carcinoma (Small Cell Lung Cancer)

Related Drugs and Biologics

1. Etoposide (VP 16)
2. Type I DNA Topoisomerases (Topoisomerase I)
3. DNA (Deoxyribonucleic Acid)
4. Razoxane (Dexrazoxane)
5. trioctyl phosphine oxide (TOPO)
6. Doxorubicin (Adriamycin)
7. DNA topoisomerase II alpha
8. P-Glycoprotein
9. Teniposide (VM 26)
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Aftercare (After-Treatment)
3. Heterologous Transplantation (Xenotransplantation)
4. Remission Induction
5. Radiotherapy