DNA Damage

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19970 relevant articles (462 outcomes, 1934 trials/studies) found for this Disease

Description: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.

Also Known As:

Injury, DNA; DNA Damages; DNA Injuries; Damage, DNA; Damages, DNA; Genotoxic Stresses; Injuries, DNA; Stresses, Genotoxic; DNA Injury; Genotoxic Stress; Stress, Genotoxic

Relationship Network

Disease Context: Research Results

Disorders of Environmental Origin

DNA Damage: 19970

Chromosome Breakage: 970

Preconception Injuries

Necrotic DNA Degradation

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinoma (Carcinomatosis)
3.	DNA Damage
4.	Anoxia (Hypoxia)
5.	Colonic Neoplasms (Colon Cancer)

Experts

1.	Kawanishi, Shosuke: 48 articles (07/2008 - 04/2002)
2.	Oikawa, Shinji: 24 articles (07/2008 - 08/2002)
3.	Hiraku, Yusuke: 23 articles (06/2008 - 08/2002)
4.	Murata, Mariko: 23 articles (06/2008 - 04/2002)
5.	Kawanishi, S: 22 articles (11/2001 - 01/2000)
6.	Loft, Steffen: 13 articles (01/2008 - 03/2002)
7.	Møller, Peter: 11 articles (01/2008 - 03/2002)
8.	Murata, M: 11 articles (11/2001 - 01/2000)
9.	Yoshida, Kiyotsugu: 10 articles (07/2008 - 05/2002)
10.	Oikawa, S: 10 articles (11/2001 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to DNA Damage:

1.	DNA (Deoxyribonucleic Acid)IBA 02/23/1998 - "The level of DNA damage produced by gamma-radiation was highly significant at doses of 0.5 and 1 Gy. Based on the mean extent of DNA migration, the level of damage was not reduced following only one hour of repair time however, after two hours, there was a significant reduction in DNA migration. " 09/01/1999 - "Addition of ascorbate to sperm preparation medium did not affect baseline DNA integrity but did provide sperm with complete protection against H(2)O(2)-induced DNA damage. " 03/01/2009 - "Groups V and VI showed a significant reduction in MeHg-induced genotoxicity (P < 0.001) when compared with group II. A negative correlation (r = -0.559, P < 0.05) was found between GSH-Px activity and DNA lesion, showing that the greater the DNA damage, the lower the GSH-Px activity. " 01/01/2009 - "pylori protection against oxidative stress-induced DNA damage, as the exposure of the HP1553 mutant cells to air for 6 h caused significant fragmentation of genomic DNA and led to cell death. " 09/01/1999 - "Although the evidence presented here is based on in vitro using isolated DNA, the results clearly demonstrate that the hot-water extract of Ganoderma lucidum shows good radioprotective ability, as well as protection against DNA damage induced by metal-catalyzed Fenton reactions and UV irradiation. " Order ALL the reference details at left...
2.	Hydrogen Peroxide (Hydroperoxide)IBA 02/01/1992 - "These observations on DNA damages might be helpful for better understanding of the effect of hydrogen peroxide on living cells in vivo." 09/01/2009 - "Their protective effects on the prevention of hydrogen peroxide induced DNA damage were also investigated. " 03/17/2009 - "DFDD protective effects against hydrogen peroxide (H(2)O(2))-induced DNA damage in vitro are demonstrated. " 07/01/2005 - "In addition, the protective effects against hydrogen peroxide-induced oxidative DNA damage in a mammalian cell line were examined. " 10/01/1995 - "The results indicate that pretreatment of lymphocytes with 10 microM hydrogen peroxide can elicit a response which is protective against DNA damage normally inducible in these cells by subsequent exposure to toxic doses of hydrogen peroxide. " Order ALL the reference details at left...
3.	AntioxidantsIBA 11/01/2006 - "The differences of protective effects on DNA damage in these four different kinds of antioxidants added before UV irradiation were statistically significant (P < 0.01). " 06/01/2002 - "These findings in dogs suggest that antioxidant supplementation can achieve sustained increases in circulating levels of antioxidants that exert a protective effect by a decrease in DNA damage, leading to improved immunological performance. " 11/01/2006 - "OBJECTIVE: To investigate the mechanism of UV-induced DNA damage and repair and the protective effects of antioxidants on DNA damage in human lens epithelial cells. " 11/01/2006 - "[UV-induced DNA damage and protective effects of antioxidants on DNA damage in human lens epithelial cells studied with comet assay]" 12/01/1999 - "Proposed mechanisms for protective effects of antioxidants have involved inhibition of free radical-mediated DNA damage. " Order ALL the reference details at left...
4.	CatalaseIBA 07/01/2004 - "Catalase, an H(2)O(2) scavenger, eliminated H(2)O(2) and reduced the As(III)-mediated DNA damage. " 01/01/1995 - "An ultrasound dose-response trend was noted for increasing pressure amplitude up to 0.82 MPa (free field) and increasing exposure duration up to 4 min. The cells were able to repair some of the strand breaks when warmed to 28 degrees C for 30 min. The effect was not eliminated by addition of catalase, which indicates that the DNA damage was not due to the action of residual H2O2 alone. " 03/13/1987 - "From the results it is concluded that the lethal effect of H2O2 is due to DNA damage induced by it and that catalase and DNA repair systems have a distinct role in protection against H2O2 in E. " 11/01/1984 - "coli with H2O2 induces protection against the toxic effects of subsequent treatment with H2O2, which cannot be attributable to catalase induction, but rather to inducible repair of oxidative DNA damage. " 09/01/1998 - "These cell strains will be of use in the study of the roles which catalase plays in the intracellular prevention of DNA damage induced by oxidative stress." Order ALL the reference details at left...
5.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/01/2006 - "On the contrary, a significant reduction of DNA damage was observed in the presence of vitamin C (at least at 200 microM). " 05/01/2009 - "Radiation protection by 6-palmitoyl ascorbic acid-2-glucoside: studies on DNA damage in vitro, ex vivo, in vivo and oxidative stress in vivo." 10/01/2007 - "The aim of this study was to investigate the protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. " 12/01/2006 - "In this study, we asked whether sperm DNA damage correlates with seminal ascorbic acid levels. " 03/01/2006 - "AIM OF TRIAL: To investigate the effect of different dose levels of dietary supplementation with vitamin C on oxidative DNA damage. " Order ALL the reference details at left...
6.	Reactive Oxygen Species (Oxygen Radicals)IBA 01/01/2002 - "CONCLUSIONS: Strain 104 is believed to grow in the presence of 28 mg l(-1) HOCl by protecting itself against HOCl by decreasing the levels of species that could react with HOCl to generate toxic reactive oxygen radicals and by improved DNA damage repair mechanisms. " 06/01/2001 - "It is postulated that the addition of medium before liquefaction could inhibit the binding of bacteria and detritus to the sperm surface and may diminish DNA damage caused by reactive oxygen species, leading to improved efficiency of fertilization. " 06/01/1993 - "The quenchers of reactive oxygen species (ROS) afforded protection against DNA damage. " 08/31/2009 - "linteus) and red ginseng extracts on DNA damage induced by reactive oxygen species (ROS) were investigated in this study. " 05/17/2009 - "The aim of this study was to assess whether microwave-induced DNA damage is basal or it is also generated through reactive oxygen species (ROS) formation. " Order ALL the reference details at left...
7.	QuercetinIBA 02/28/2008 - "The protective effects of quercetin against t-BHP-induced DNA damage seem to be due to both direct effects on t-BHP toxicity and to cellularly mediated indirect effects which reflect the potentiation of the cellular antioxidant defenses. " 06/30/2008 - "Quercetin ameliorates gamma radiation-induced DNA damage and biochemical changes in human peripheral blood lymphocytes." 01/01/2006 - "This response was dose dependent: a protection against UVC-induced DNA damage in cells with overexpressed Hsp70 was observed at UVC dose 20 J/m2 with a maximum at 40 J/m2 when compared with cells with normal Hsp70 levels and in quercetin-treated cells. " 09/01/2008 - "The results of our study prove that changes in the antioxidant state, caused by quercetin, do not lead to DNA damage or exert any pro-apoptotic activity in vivo." 11/01/2009 - "Quercetin (1, 100 microM) significantly reduced oxidative DNA damage, as measured by the number of single-strand breaks identified by single cell gel electrophoresis. " Order ALL the reference details at left...
8.	Vitamin E FDA Link 04/11/2007 - "The perturbation of the oxidative status was further confirmed by the significant reduction of the induced oxidative DNA damage as well as stress protein induction when cells were pre-treated with Vitamin E prior to exposure to ZEN. " 03/01/2007 - "We studied the efficacy of vitamin E against both oxidative DNA damage and autoantibody production in SLE. " 08/01/1998 - "In order to estimate the effect of vitamin E on DNA injury and K-ras point mutation at an early stage of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK)-induced lung tumorigenesis in mice, the present study was carried out. " 09/01/2008 - "Moreover, these data indicate that E(2) and MXC produce oxidative DNA damage in the OSE, and that this damage is prevented by the anti-oxidant vitamin E." 02/01/2008 - "These results suggest that a vitamin E and A and GSPE enriched-diets have a protective effect on oxidative DNA damage limited to rat leukocytes." Order ALL the reference details at left...
9.	EnzymesIBA 01/01/2003 - "In conclusion, our findings indicate that i) mustard juice is highly protective against B(a)P-induced DNA damage in human derived cells and ii) that induction of detoxifying enzymes may account for its chemoprotective properties. " 08/03/2009 - "Moreover, results of comet assay in V79 cells, employing Fpg, Endo III, and Endo V enzymes, demonstrated significant reduction of UVC-induced DNA damage after pre-incubation with these extracts. " 07/01/2008 - "Our study supports the idea that there might also be other mechanisms by which antioxidant enzymes (especially GST) protect cells against oxidative DNA damage." 01/01/2003 - "However, HSV-1 also serves as an excellent model system to study genome transactions, including DNA replication, homologous recombination, and the interaction of DNA replication enzymes with DNA damage. " 01/01/1991 - "In this study we have further investigated the roles of individual rat and human P450 enzymes in the bioactivation of this hepatocarcinogen in a Salmonella typhimurium TA1535/pSK1002 system where umu response is indicative of DNA damage. " Order ALL the reference details at left...
10.	MelatoninIBA 03/01/2001 - "It is concluded that melatonin, IPA and AA may be effective in protecting against E(2)-related DNA damage and, consequently, carcinogenesis." 03/01/2004 - "Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain." 05/01/2009 - "AIM OF STUDY: To establish weather an administration of melatonin decreases oxidative DNA damage in gastric mucosa cells. " 05/01/2009 - "The melatonin administration changes the above mentioned oxidative DNA damage significantly." 04/01/2009 - "We conclude that the antiapoptotic effects of melatonin were mediated by two potential mechanisms: by increasing the activity of prosurvival pathways via Akt and by the prevention of DNA damage (via ATM inhibition) followed by the reduction of cell cycle re-entry." Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/2003 - "Although p53 is clearly involved in the salvage pathway to DNA damage, its frequent mutations do not explain the efficacy of radiotherapy and chemotherapy. " 06/01/2008 - "The aim of the present study was to evaluate DNA damage (micronucleus) in cytokinesis-blocked lymphocytes and exfoliated buccal mucosa cells from children with malignant tumours and under chemotherapy. " 10/01/2001 - "Although the initial impetus for examining EGFR signal interruption as an anticancer strategy involved proliferative growth inhibition, more recent studies now confirm the capacity of EGFR down-regulation to modify apoptosis, invasion capacity, angiogenesis, DNA damage repair, and cellular response to radiation and selected chemotherapy agents. " 06/01/1999 - "This method may be useful not only in experimental settings but also in studies of DNA damage in humans resulting from chemotherapy or exposure to environmental agents." 12/01/1985 - "The response to this chemotherapy-radiation combination treatment was measured by cell survival studies and DNA damage as determined by alkaline elution assay. " Order ALL the reference details at left...
2.	Chemoprevention 12/26/2006 - "These studies will have important implications for APC in DNA damage-induced carcinogenesis and chemoprevention." 12/01/2000 - "However, the study demonstrates that DNA damage is a useful end point in chemoprevention trials." 06/28/2005 - "One of the rational and effective strategies for chemoprevention is the blockade of DNA damage caused by carcinogenic insult. " 03/01/2005 - "A chemoprevention of photosensitized DNA damage is one of the most important methods for the above phototoxic effects. " 07/13/2004 - "It is possible that understanding diet:gene interactions in DNA damage and in repair will not only explain much of the inter-individual variation in risk but also offer opportunities to design better dietary intervention studies aimed at chemoprevention. " Order ALL the reference details at left...
3.	Lasers (Laser) 03/01/2009 - "The dependence of the induced protection against 1064 nm trapping beam irradiation induced DNA damage on the time interval between the two irradiations as well as the He-Ne laser pre-irradiation parameters is presented." 03/01/2009 - "He-Ne laser (632.8 nm) pre-irradiation gives protection against DNA damage induced by a near-infrared trapping beam." 09/01/2009 - "Spatially sculpted laser scissors for study of DNA damage and repair." 05/01/2009 - "Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells." 03/01/2009 - "We report the results of a study carried out to investigate the effect of He-Ne laser (632.8 nm) pre-irradiation on DNA damage induced by continuous wave 1064 nm trapping beam exposure in MCF-7 cells. " Order ALL the reference details at left...
4.	Renal Dialysis (Hemodialysis) 12/08/2008 - "This study used the comet assay to assess the levels of DNA damage before, immediately after and 48 h after the hemodialysis session in 25 patients with T2DM and in a group of 20 healthy individuals, selected according to mean age, sex and smoking habit. " 12/08/2008 - "Our results showed increased levels of DNA damage in hemodialysis-dependent T2DM individuals (12.36+/-8.04) when compared with healthy individuals (7.35+/-7.41) (p=0.014). " 12/08/2008 - "However, no information is available in the literature concerning the levels of DNA damage in T2DM individuals who are dependent on hemodialysis. " 01/01/2008 - "It is well known that long periods of hemodialysis treatment are linked to DNA damage due to oxidative stress. " 01/01/2005 - "BACKGROUND/AIMS: Chronic renal patients on hemodialysis (HD) and peritoneal dialysis (PD) treatment are exposed to oxidative stress and DNA damage. " Order ALL the reference details at left...
5.	Oral Administration 08/01/2009 - "AE induced primary DNA damage in the liver and in the kidney as observed between 3 and 6h after two oral administrations at 500, 1000 and 2000mg/kg bw, underlining an in vivo genotoxic mechanism of action. " 06/01/2008 - "cordata extract and/or Sangrovit induced no DNA damage to rat lymphocytes or hepatocytes after 90-days oral administration. " 03/29/2008 - "Following a single oral administration of 2 and 4mg/kg bw of MC-LR, a statistically significant induction of DNA damage in blood cells was obtained after 3h. " 11/05/1999 - "The oral administration of AFB1 (1 x 100 microg/kg b.w./week) did not induce DNA damage in jejunal epithelial cells. " 09/18/1997 - "Mice were sacrificed 1, 3, 6, and 24 h after oral administration of the mutagen at 100 mg/kg. MX yielded statistically significant DNA damage in the liver, kidney, lung, and brain and in all the mucosa samples. " Order ALL the reference details at left...

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