DNA Damage

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18080 relevant articles (421 outcomes, 1723 trials/studies) found for this Disease

Description: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.

Also Known As:

Injury, DNA; DNA Damages; DNA Injuries; Damage, DNA; Damages, DNA; Genotoxic Stresses; Injuries, DNA; Stresses, Genotoxic; DNA Injury; Genotoxic Stress; Stress, Genotoxic

Relationship Network

Disease Context: Research Results

Disorders of Environmental Origin

DNA Damage: 18080

Chromosome Breakage: 937

Preconception Injuries

Necrotic DNA Degradation

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinoma (Carcinomatosis)
3.	Anoxia (Hypoxia)
4.	DNA Damage
5.	Breast Neoplasms (Breast Cancer)
378 Diseases and 3272 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Kawanishi, Shosuke: 48 articles (07/2008 - 04/2002)
2.	Oikawa, Shinji: 24 articles (07/2008 - 08/2002)
3.	Hiraku, Yusuke: 23 articles (06/2008 - 08/2002)
4.	Murata, Mariko: 23 articles (06/2008 - 04/2002)
5.	Kawanishi, S: 22 articles (11/2001 - 01/2000)
6.	Loft, Steffen: 13 articles (01/2008 - 03/2002)
7.	Møller, Peter: 11 articles (01/2008 - 03/2002)
8.	Murata, M: 11 articles (11/2001 - 01/2000)
9.	Yoshida, Kiyotsugu: 10 articles (07/2008 - 05/2002)
10.	Oikawa, S: 10 articles (11/2001 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to DNA Damage:

1.	DNA (Deoxyribonucleic Acid)IBA 02/23/1998 - "The level of DNA damage produced by gamma-radiation was highly significant at doses of 0.5 and 1 Gy. Based on the mean extent of DNA migration, the level of damage was not reduced following only one hour of repair time however, after two hours, there was a significant reduction in DNA migration" 09/01/1999 - "Addition of ascorbate to sperm preparation medium did not affect baseline DNA integrity but did provide sperm with complete protection against H(2)O(2)-induced DNA damage" 09/01/1999 - "Although the evidence presented here is based on in vitro using isolated DNA, the results clearly demonstrate that the hot-water extract of Ganoderma lucidum shows good radioprotective ability, as well as protection against DNA damage induced by metal-catalyzed Fenton reactions and UV irradiation" 07/01/1995 - "This DNA damage may be in part depurination, and a purified alpha/beta-type SASP gave significant protection against dry heat-induced DNA depurination in vitro." 11/01/1990 - "Twelve weeks after the beginning of treatment, DNA damage could be detected in the liver DNA of rats receiving either CDAADD or CDD, the degree being significantly greater in the former case" Get all the results and reference details, order at left...
2.	Hydrogen Peroxide (Hydroperoxide)IBA 02/01/1992 - "These observations on DNA damages might be helpful for better understanding of the effect of hydrogen peroxide on living cells in vivo." 07/01/2005 - "In addition, the protective effects against hydrogen peroxide-induced oxidative DNA damage in a mammalian cell line were examined" 10/01/1995 - "The results indicate that pretreatment of lymphocytes with 10 microM hydrogen peroxide can elicit a response which is protective against DNA damage normally inducible in these cells by subsequent exposure to toxic doses of hydrogen peroxide" 11/01/1989 - "Induction of the SOS response by hydrogen peroxide in various Escherichia coli mutants with altered protection against oxidative DNA damage." 10/01/2007 - "In this study, we investigated the biological role of hOGG1 in DNA damage-related apoptosis induced by hydrogen peroxide (H(2)O(2))-derived oxidative stress" Get all the results and reference details, order at left...
3.	AntioxidantsIBA 11/01/2006 - "The differences of protective effects on DNA damage in these four different kinds of antioxidants added before UV irradiation were statistically significant (P < 0.01)" 06/01/2002 - "These findings in dogs suggest that antioxidant supplementation can achieve sustained increases in circulating levels of antioxidants that exert a protective effect by a decrease in DNA damage, leading to improved immunological performance" 11/01/2006 - "OBJECTIVE: To investigate the mechanism of UV-induced DNA damage and repair and the protective effects of antioxidants on DNA damage in human lens epithelial cells" 11/01/2006 - "UV-induced DNA damage and protective effects of antioxidants on DNA damage in human lens epithelial cells studied with comet assay]" 12/01/1999 - "Proposed mechanisms for protective effects of antioxidants have involved inhibition of free radical-mediated DNA damage" Get all the results and reference details, order at left...
4.	CatalaseIBA 07/01/2004 - "Catalase, an H(2)O(2) scavenger, eliminated H(2)O(2) and reduced the As(III)-mediated DNA damage" 01/01/1995 - "An ultrasound dose-response trend was noted for increasing pressure amplitude up to 0.82 MPa (free field) and increasing exposure duration up to 4 min. The cells were able to repair some of the strand breaks when warmed to 28 degrees C for 30 min. The effect was not eliminated by addition of catalase, which indicates that the DNA damage was not due to the action of residual H2O2 alone" 03/13/1987 - "From the results it is concluded that the lethal effect of H2O2 is due to DNA damage induced by it and that catalase and DNA repair systems have a distinct role in protection against H2O2 in E" 11/01/1984 - "coli with H2O2 induces protection against the toxic effects of subsequent treatment with H2O2, which cannot be attributable to catalase induction, but rather to inducible repair of oxidative DNA damage" 09/01/1998 - "These cell strains will be of use in the study of the roles which catalase plays in the intracellular prevention of DNA damage induced by oxidative stress." Get all the results and reference details, order at left...
5.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/01/2006 - "On the contrary, a significant reduction of DNA damage was observed in the presence of vitamin C (at least at 200 microM)" 10/01/2007 - "The aim of this study was to investigate the protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay" 12/01/2006 - "In this study, we asked whether sperm DNA damage correlates with seminal ascorbic acid levels" 03/01/2006 - "AIM OF TRIAL: To investigate the effect of different dose levels of dietary supplementation with vitamin C on oxidative DNA damage" 10/01/2005 - "This study investigated baseline (entry) fasting plasma ascorbic acid, lymphocytic DNA damage and glycaemic control in Type 2 DM as part of a long-term study, the aim of which is to explore a biomarker profiling approach to identify and improve outcome in high-risk subjects" Get all the results and reference details, order at left...
6.	Reactive Oxygen Species (Oxygen Radicals)IBA 01/01/2002 - "CONCLUSIONS: Strain 104 is believed to grow in the presence of 28 mg l(-1) HOCl by protecting itself against HOCl by decreasing the levels of species that could react with HOCl to generate toxic reactive oxygen radicals and by improved DNA damage repair mechanisms" 06/01/2001 - "It is postulated that the addition of medium before liquefaction could inhibit the binding of bacteria and detritus to the sperm surface and may diminish DNA damage caused by reactive oxygen species, leading to improved efficiency of fertilization" 06/01/1993 - "The quenchers of reactive oxygen species (ROS) afforded protection against DNA damage" 01/01/2008 - "PURPOSE: The goal of this study was to investigate whether superposing of electromagnetic noise could block or attenuate DNA damage and intracellular reactive oxygen species (ROS) increase of cultured human lens epithelial cells (HLECs) induced by acute exposure to 1.8 GHz radiofrequency field (RF) of the Global System for Mobile Communications (GSM)" 07/01/2007 - "The purpose of this study was to analyze the combined effects of regular exercise and ginseng supplementation on peritoneal exudate ROS (reactive oxygen species), lymphocyte proliferation by splenocytes, and DNA damage following exhaustive exercise stress" Get all the results and reference details, order at left...
7.	QuercetinIBA 02/28/2008 - "The protective effects of quercetin against t-BHP-induced DNA damage seem to be due to both direct effects on t-BHP toxicity and to cellularly mediated indirect effects which reflect the potentiation of the cellular antioxidant defenses" 06/30/2008 - "Quercetin ameliorates gamma radiation-induced DNA damage and biochemical changes in human peripheral blood lymphocytes." 01/01/2006 - "This response was dose dependent: a protection against UVC-induced DNA damage in cells with overexpressed Hsp70 was observed at UVC dose 20 J/m2 with a maximum at 40 J/m2 when compared with cells with normal Hsp70 levels and in quercetin-treated cells" 09/01/2008 - "The results of our study prove that changes in the antioxidant state, caused by quercetin, do not lead to DNA damage or exert any pro-apoptotic activity in vivo." 09/01/2008 - "Quercetin administration to the rats did not induce either DNA damage or apoptosis in the examined cells" Get all the results and reference details, order at left...
8.	MelatoninIBA 03/01/2001 - "It is concluded that melatonin, IPA and AA may be effective in protecting against E(2)-related DNA damage and, consequently, carcinogenesis." 03/01/2004 - "Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain." 09/01/2008 - "Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair." 12/01/2007 - "Since such type of DNA damage is reflected in oxidative base modifications that are primarily repaired by base-excision repair (BER), we tried to investigate in the present work whether melatonin could influence this DNA-repair system" 12/01/2007 - "Protective action of melatonin against oxidative DNA damage: chemical inactivation versus base-excision repair." Get all the results and reference details, order at left...
9.	Vitamin E FDA Link 04/11/2007 - "The perturbation of the oxidative status was further confirmed by the significant reduction of the induced oxidative DNA damage as well as stress protein induction when cells were pre-treated with Vitamin E prior to exposure to ZEN" 03/01/2007 - "We studied the efficacy of vitamin E against both oxidative DNA damage and autoantibody production in SLE" 08/01/1998 - "In order to estimate the effect of vitamin E on DNA injury and K-ras point mutation at an early stage of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK)-induced lung tumorigenesis in mice, the present study was carried out" 09/01/2008 - "Moreover, these data indicate that E(2) and MXC produce oxidative DNA damage in the OSE, and that this damage is prevented by the anti-oxidant vitamin E." 02/01/2008 - "These results suggest that a vitamin E and A and GSPE enriched-diets have a protective effect on oxidative DNA damage limited to rat leukocytes." Get all the results and reference details, order at left...
10.	EnzymesIBA 01/01/2003 - "In conclusion, our findings indicate that i) mustard juice is highly protective against B(a)P-induced DNA damage in human derived cells and ii) that induction of detoxifying enzymes may account for its chemoprotective properties" 07/01/2008 - "Our study supports the idea that there might also be other mechanisms by which antioxidant enzymes (especially GST) protect cells against oxidative DNA damage." 01/01/2003 - "However, HSV-1 also serves as an excellent model system to study genome transactions, including DNA replication, homologous recombination, and the interaction of DNA replication enzymes with DNA damage" 01/01/1991 - "In this study we have further investigated the roles of individual rat and human P450 enzymes in the bioactivation of this hepatocarcinogen in a Salmonella typhimurium TA1535/pSK1002 system where umu response is indicative of DNA damage" 06/11/1984 - "The biological implications of the results of the conformational studies, reported here, have been examined vis-a-vis the currently available models for the recognition of DNA "damage" by repair enzymes." Get all the results and reference details, order at left...
3822 Drugs and Important Bio-Agents and 17882 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/2003 - "Although p53 is clearly involved in the salvage pathway to DNA damage, its frequent mutations do not explain the efficacy of radiotherapy and chemotherapy" 06/01/2008 - "The aim of the present study was to evaluate DNA damage (micronucleus) in cytokinesis-blocked lymphocytes and exfoliated buccal mucosa cells from children with malignant tumours and under chemotherapy" 10/01/2001 - "Although the initial impetus for examining EGFR signal interruption as an anticancer strategy involved proliferative growth inhibition, more recent studies now confirm the capacity of EGFR down-regulation to modify apoptosis, invasion capacity, angiogenesis, DNA damage repair, and cellular response to radiation and selected chemotherapy agents" 06/01/1999 - "This method may be useful not only in experimental settings but also in studies of DNA damage in humans resulting from chemotherapy or exposure to environmental agents." 12/01/1985 - "The response to this chemotherapy-radiation combination treatment was measured by cell survival studies and DNA damage as determined by alkaline elution assay" Get all the results and reference details, order at left...
2.	Chemoprevention 12/26/2006 - "These studies will have important implications for APC in DNA damage-induced carcinogenesis and chemoprevention." 12/01/2000 - "However, the study demonstrates that DNA damage is a useful end point in chemoprevention trials." 06/28/2005 - "One of the rational and effective strategies for chemoprevention is the blockade of DNA damage caused by carcinogenic insult" 03/01/2005 - "A chemoprevention of photosensitized DNA damage is one of the most important methods for the above phototoxic effects" 07/13/2004 - "It is possible that understanding diet:gene interactions in DNA damage and in repair will not only explain much of the inter-individual variation in risk but also offer opportunities to design better dietary intervention studies aimed at chemoprevention" Get all the results and reference details, order at left...
3.	Renal Dialysis (Hemodialysis) 01/01/2008 - "It is well known that long periods of hemodialysis treatment are linked to DNA damage due to oxidative stress" 01/01/2005 - "BACKGROUND/AIMS: Chronic renal patients on hemodialysis (HD) and peritoneal dialysis (PD) treatment are exposed to oxidative stress and DNA damage" 04/11/2006 - "Median DNA damage levels of the study groups were as follows: hepatitis C (+) maintenance hemodialysis subjects, 88 (0-232); hepatitis C (-) maintenance hemodialysis subjects, 58 (0-228); hepatitis C (+) subjects without renal disease, 112 (44-252); controls, 26 (0-72)" 04/11/2006 - "Both maintenance hemodialysis subjects with and without HCV infection had significantly higher DNA damage level than healthy controls (both p<0.05/6)" 04/11/2006 - "DNA damage level was significantly higher among hepatitis C (+) subjects without renal disease than hepatitis C (-) maintenance hemodialysis subjects and healthy controls (both p<0.05/6)" Get all the results and reference details, order at left...
4.	Radioimmunotherapy 02/01/1999 - "Low-dose stimulation of the immune system may not only prevent cancer by increasing removal of premalignant or malignant cells with persistent DNA damage, but used in human radioimmunotherapy may also completely remove malignant tumors with metastases" 05/01/1992 - "We conjecture that the efficacy of radioimmunoconjugates against responsive cell types may be the result of passive DNA damage by ionizing radiation and the initiation of apoptosis in response to radioimmunotherapy." 10/01/2005 - "PURPOSE: The purpose of this study was to analyze different mechanisms (cell cycle synchronization, DNA damage, and apoptosis) that might underlie potential synergy between chemotherapy (paclitaxel or doxorubicin) and radioimmunotherapy with alpha radionuclides" Get all the results and reference details, order at left...
5.	Electrodes (Electrode) 01/01/2007 - "RESULTS: 1OHP and primary DNA damage were significantly higher in electrode workers compared to reference subjects" 07/01/2008 - "Intensity of the marker signal measured at the pyrolytic graphite electrode responded well to the extent of DNA damage" 01/01/2006 - "Cells with increased DNA damage display increased migration of chromosomal DNA from the nucleus toward the anode, which resembles the shape of a comet" 01/01/2005 - "Cells with increased DNA damage display increased migration of chromosomal DNA from the nucleus toward the anode, which resembles the shape of a comet" 06/01/2000 - "The extent of DNA damage increased with the shift of the electrode potential to negative values, displaying a sharp inflection point matching the potential of [Fe(EDTA)]2-/[Fe(EDTA)]- redox pair" Get all the results and reference details, order at left...
86 Therapies and Procedures and 644 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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