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Disulfiram (Antabuse)

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Also Known As:
Antabuse; Antabus; Alcophobin; Allphar Brand of Disulfiram; Altana Pharma Brand of Disulfiram; Anticol; Artu Brand of Disulfiram; Bis(diethylthiocarbamoyl) Disulfide; Bohm Brand of Disulfiram; Dicupral; Dumex Brand of Disulfiram; Esperal; Odyssey Brand of Disulfiram; Orphan Brand of Disulfiram; Refusal; Sanofi Synthelabo Brand of Disulfiram; Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2; Teturam; Disulfide, Tetraethylthiuram; Tetraethylthiuram Disulfide; Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-
Networked: 969 relevant articles (64 outcomes, 102 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Ito, Yoshimasa: 12 articles (01/2015 - 02/2003)
2. Nagai, Noriaki: 10 articles (01/2015 - 12/2007)
3. Kosten, Thomas R: 10 articles (03/2014 - 04/2002)
4. Wang, Weiguang: 9 articles (10/2015 - 04/2003)
5. Kast, Richard E: 8 articles (04/2015 - 02/2009)
6. Nich, Charla: 8 articles (12/2014 - 03/2004)
7. Weinshenker, David: 7 articles (07/2014 - 10/2006)
8. Dou, Q Ping: 7 articles (01/2014 - 11/2006)
9. Mutschler, Jochen: 7 articles (01/2013 - 01/2008)
10. Petrakis, Ismene L: 7 articles (10/2006 - 03/2004)

Related Diseases

1. Alcoholism (Alcohol Abuse)
2. Cocaine-Related Disorders (Cocaine Addiction)
3. Neoplasms (Cancer)
4. Poisoning
5. Post-Traumatic Stress Disorders (PTSD)

Related Drugs and Biologics

1. Cocaine (Cocaine HCl)
2. Methadone (Dolophine)
3. Naltrexone (ReVia)
4. Aldehyde Dehydrogenase
5. Nickel
6. Cyanamide (Calcium Carbimide)
7. Carbon Monoxide
8. Butylated Hydroxyanisole (BHA)
9. Ditiocarb (Sodium Diethyldithiocarbamate)
10. Dopamine (Intropin)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Oral Administration
3. Chelation Therapy (Therapy, Chelation)
4. Lenses
5. Enterosorption