|1.||Ito, Yoshimasa: 12 articles (01/2015 - 02/2003)|
|2.||Nagai, Noriaki: 10 articles (01/2015 - 12/2007)|
|3.||Kosten, Thomas R: 10 articles (03/2014 - 04/2002)|
|4.||Wang, Weiguang: 9 articles (10/2015 - 04/2003)|
|5.||Kast, Richard E: 8 articles (04/2015 - 02/2009)|
|6.||Nich, Charla: 8 articles (12/2014 - 03/2004)|
|7.||Weinshenker, David: 7 articles (07/2014 - 10/2006)|
|8.||Dou, Q Ping: 7 articles (01/2014 - 11/2006)|
|9.||Mutschler, Jochen: 7 articles (01/2013 - 01/2008)|
|10.||Petrakis, Ismene L: 7 articles (10/2006 - 03/2004)|
|1.||Alcoholism (Alcohol Abuse)
08/01/2007 - "This case highlights the potential dangers of disulfiram, a drug that can be beneficial in the short term, but not proven to improve long-term outcome in the treatment of alcoholism."
09/01/2011 - "Disulfiram is effective in relapse prevention in alcoholism. "
05/01/2003 - "Controlled research has shown that supervised disulfiram is an effective treatment for alcoholism. "
01/01/1993 - "Disulfiram has been used effectively to deter alcohol consumption in patients with a history of alcohol abuse. "
04/01/1991 - "Disulfiram, widely used in avoidance therapy for alcohol abuse, has been shown to have protective effects against chemically induced toxicity and carcinogenesis. "
|2.||Cocaine-Related Disorders (Cocaine Addiction)
12/01/2013 - "Disulfiram (DSF), used for the treatment of alcohol use disorders (AUDs) for over six decades, most recently has shown promise for treating cocaine dependence. "
02/01/2013 - "A variant in the gene encoding DβH leads to reduced DβH activity, and as such, disulfiram might not be an effective treatment of cocaine dependence for individuals with this variant. "
04/01/2004 - "Converging evidence suggests that disulfiram is a promising treatment for cocaine dependence. "
01/01/2012 - "This study indicates that a patient's MTHFR genotype may be used to identify individuals who might show improved response to disulfiram treatment for cocaine dependence. "
12/01/2011 - "Previous studies demonstrated efficacy of disulfiram in the treatment of cocaine dependence among patients with comorbid alcohol use disorder or opioid dependence. "
03/01/2014 - "The alcohol aversion drug disulfiram (DSF) reacts and conjugates with the protein-bound nucleophilic cysteines and is known to elicit anticancer effects alone or improve the efficacy of many cancer drugs. "
10/15/2013 - "However, disulfiram has complex pharmacokinetics and is rapidly eliminated which limits its use as a tumor treatment. "
01/01/2007 - "These results together with large clinical experience and relatively mild side effects encourage clinical studies of disulfiram as an anti-cancer agent."
12/01/1979 - "A significant elevation in the levels of radioactivity in washed liver nuclei obtained from animals receiving dietary disulfiram was also noted, suggesting a relationship between nuclear uptake and the increased incidence of liver tumors appearing in the disulfiran group in the inhalation study."
02/01/2015 - "This relationship between disulfiram toxicity and ionophore activity was consolidated via synthesis of a new disulfiram analog and overall we demonstrate a novel mechanism of disulfiram-cytotoxicity with significant clinical implications for future use as a cancer therapeutic."
06/01/1993 - "The efficacy of single-dose disulfiram as an inhibitor of human P450 2E1 suggests that this modality for manipulating clinical P450 2E1 activity may provide a useful probe for delineating P450 2E1 participation in human drug biotransformation or for the treatment of poisoning by P450 2E1-activated toxins."
06/15/1977 - "Electron microscopic studies on the cerebral lesions of rats in experimental chronic disulfiram poisoning."
01/01/1976 - "[Ultrastructural study of the central and peripheral nervous systems in experimental poisoning by tetraethylthiuram disulfide: preliminary studies]."
01/01/2016 - "Discussion Although disulfiram was given late in the course of the poisoning it is possible that it contributed to the recovery. "
09/01/2013 - "Disulfiram poisoning causing acute encephalopathy."
|5.||Post-Traumatic Stress Disorders (PTSD)
01/01/2008 - "Further, both PTSD and non-PTSD clients showed good compliance with BCT, attending a high number of BCT sessions, taking Antabuse, and going to AA. "
10/01/2006 - "Subjects with PTSD had better alcohol outcomes with active medication (naltrexone, disulfiram or the combination) than they did on placebo; overall psychiatric symptoms of PTSD improved. "
10/01/2006 - "The results of this study suggest that disulfiram and naltrexone are effective and safe for individuals with PTSD and comorbid alcohol dependence."
02/01/2014 - "Another clinical trial demonstrated the efficacy of both disulfiram and naltrexone for the treatment of AD in individuals with PTSD. "
10/01/2006 - "Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder."
|1.||Cocaine (Cocaine HCl)
|6.||Cyanamide (Calcium Carbimide)
|8.||Butylated Hydroxyanisole (BHA)
|9.||Ditiocarb (Sodium Diethyldithiocarbamate)
|1.||Drug Therapy (Chemotherapy)
|3.||Chelation Therapy (Therapy, Chelation)