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Diprenorphine

A narcotic antagonist similar in action to NALOXONE. It is used to remobilize animals after ETORPHINE neuroleptanalgesia and is considered a specific antagonist to etorphine.
Also Known As:
Diprenorphine Hydrochloride; Revivon; Hydrochloride, Diprenorphine; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,alpha-dimethyl-, (5alpha,7alpha)-
Networked: 53 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hammers, Alexander: 3 articles (10/2013 - 04/2005)
2. Brooks, David J: 3 articles (10/2013 - 04/2005)
3. Jones, Anthony K P: 2 articles (11/2015 - 10/2004)
4. Koepp, Matthias J: 2 articles (10/2013 - 04/2007)
5. Duncan, John S: 2 articles (10/2013 - 04/2007)
6. Asselin, Marie-Claude: 2 articles (04/2007 - 04/2005)
7. Boecker, Henning: 2 articles (05/2006 - 04/2005)
8. Sprenger, Till: 2 articles (05/2006 - 04/2005)
9. Willoch, Frode: 2 articles (05/2006 - 04/2004)
10. Straube, A: 2 articles (04/2006 - 09/2002)

Related Diseases

1. Pain (Aches)
2. Hypovolemia
3. Neuroblastoma
4. Seizures (Seizure)
12/01/1993 - "It was possible to simulate the observed increased diprenorphine elimination following seizures in cerebral cortex using a two tissue compartment model, with an estimated 15-41% decrease in the specific tracer uptake rate constant (k3). "
04/01/2007 - "We scanned nine patients within hours of spontaneous temporal lobe seizures and compared their postictal binding of the non-subtype selective opioid receptor PET radioligand [11C]diprenorphine (DPN), quantified as a volume-of-distribution (VD), with interictal binding and with binding changes in 14 healthy controls, controlling for a range of behavioural variables associated with opioid action. "
10/01/2013 - "Previous positron emission tomography (PET) studies in refractory temporal lobe epilepsy (TLE) using the non-selective opioid receptor antagonist [(11)C]diprenorphine (DPN) did not detect any changes in mesial temporal structures, despite known involvement of the hippocampus in seizure generation. "
01/01/1987 - "We have tested whether the opioid antagonists naloxone (2 mg/kg), naltrexone (2 mg/kg) and diprenorphine (0.2 mg/kg), and the agonist morphine (4-8 mg/kg) given subcutaneously (10 min before ethanol for 7 days) modify the ethanol withdrawal syndrome (audiogenic seizures) following chronic ethanol intoxication in rats. "
03/01/1985 - "The action of opiate receptor agonists: (D-Ala2)-methionine enkephalinamide (D-MEA), morphine, heroin, etorphine, and antagonists: naloxone and diprenorphine on audiogenic seizures was tested during ethanol abstinence. "
5. Temporal Lobe Epilepsy

Related Drugs and Biologics

1. Vasopressins (Vasopressin)
2. Opioid Receptors (Opioid Receptor)
3. NAD (NADH)
4. Enkephalins
5. Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)
6. Leucine-2-Alanine Enkephalin (Enkephalin, Leucine 2 Alanine)
7. mu Opioid Receptors (mu Opioid Receptor)
8. carfentanil (carfentanyl)
9. delta Opioid Receptors (delta Opioid Receptor)
10. Halothane (Fluothane)

Related Therapies and Procedures

1. Subcutaneous Injections
2. Injections
3. Analgesia