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Diphtheria Toxin

An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
Also Known As:
Toxin, Corynebacterium Diphtheriae; Corynebacterium Diphtheriae Toxin
Networked: 491 relevant articles (19 outcomes, 47 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Frankel, Arthur E: 27 articles (01/2013 - 01/2002)
2. Hochberg, Abraham: 12 articles (06/2014 - 03/2005)
3. Vallera, Daniel A: 9 articles (09/2013 - 02/2002)
4. Frankel, A E: 9 articles (02/2009 - 04/2000)
5. Sing, Andreas: 7 articles (01/2015 - 06/2002)
6. Hall, Walter A: 7 articles (09/2013 - 04/2002)
7. Thorburn, Andrew: 7 articles (01/2013 - 11/2002)
8. Kreitman, Robert J: 7 articles (01/2009 - 05/2002)
9. Ohana, Patricia: 6 articles (01/2013 - 03/2005)
10. Birman, Tatiana: 6 articles (01/2012 - 03/2005)

Related Diseases

1. Neoplasms (Cancer)
2. Diphtheria
3. Glioblastoma (Glioblastoma Multiforme)
4. Mesothelioma
5. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)

Related Drugs and Biologics

1. Interleukin-2 (IL2)
2. denileukin diftitox (Ontak)
3. Proteins (Proteins, Gene)
4. Interleukin-2 Receptors (IL 2 Receptor)
5. Immunotoxins (Immunotoxin)
6. DNA (Deoxyribonucleic Acid)
7. Interleukins
8. Vaccines
9. Transferrin (beta 2 Transferrin)
10. A-Form DNA (A-DNA)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Heterologous Transplantation (Xenotransplantation)
3. Immunotherapy
4. Injections
5. Intravenous Injections