Diosgenin

A spirostan found in DIOSCOREA and other plants. The 25S isomer is called yamogenin. Solasodine is a natural derivative formed by replacing the spiro-ring with a nitrogen, which can rearrange to SOLANINE.

Also Known As:

Networked: 335 relevant articles (38 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liagre, Bertrand: 13 articles (11/2021 - 04/2003)
2.	Huang, Wen: 11 articles (06/2022 - 03/2010)
3.	Beneytout, Jean-Louis: 9 articles (01/2014 - 04/2003)
4.	Beneytout, J L: 7 articles (02/2011 - 10/2001)
5.	Liagre, B: 7 articles (02/2011 - 10/2001)
6.	Niu, Hai: 6 articles (06/2022 - 01/2016)
7.	Wei, Zeliang: 6 articles (06/2022 - 01/2016)
8.	Xin, Guang: 6 articles (06/2022 - 01/2013)
9.	Baluchnejadmojarad, Tourandokht: 6 articles (10/2021 - 12/2015)
10.	Roghani, Mehrdad: 6 articles (10/2021 - 12/2015)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2021 - "Diosgenin is proved to be beneficial in terms curing cancer of various types but majorly include lung, liver, colon breast, and prostate. " 12/01/2021 - "Cancer cure with diosgenin is providing a new base to the pharmaceutical and medical researchers to commence new and more specific journey of diosgenin. " 10/10/2018 - "Taken together, diosgenin can be used as a microecological regulator to induce antitumor immunity and improve the efficacy of immune checkpoint antibody, making it more suitable for the treatment of malignant tumors." 01/01/2018 - "Several novel diosgenin analogs and nano-formulations have been synthesized with improved anti-cancer efficacy and pharmacokinetic profile. " 10/01/2021 - "In our previous study, we showed that a novel diosgenin derivative 8d (DG-8d), which contained 5-(3-pyridyl)-1,3,4-thiadiazole moiety, had significant cytotoxic activity on human tumor cells, especially the A549 cells. "
2.	Inflammation (Inflammations) 05/01/2019 - "Collectively, diosgenin ameliorates testicular damage in DM, at least via partial suppression of apoptosis, oxidative stress, inflammation, and neutrophil infiltration and also via partial restoration of mitochondrial integrity." 05/01/2022 - "This study concludes that diosgenin attenuates ER stress-induced inflammation in diabetic rat aorta by modulating the expression of pro-inflammatory, iRhom2/TACE mediated mechanism and hence diosgenin can be a therapeutic drug for the treatment of diabetes-induced inflammation." 01/01/2022 - "This study aimed to evaluate the effects of diosgenin on oxidative stress and inflammation in mice fed with a high-fat diet (HFD). " 01/01/2023 - "The results further showed that diosgenin caused a strong correlation between gut microbiota composition and inflammation, the HPA axis activity, or hippocampus neurotrophic function. " 01/01/2023 - "The effects of diosgenin on behaviors, inflammation, neuroendocrine, neurotrophic function, and gut microbiota were evaluated. "
3.	Carcinogenesis 01/01/2022 - "The nude mouse tumorigenesis assay indicated that the parameters of tumorous volume and mass of diosgenin treatment group were greatly decreased as compared to control, and as the concentration of diosgenin increased, the inhibitory effect was more significant. " 04/01/2012 - "Anti-tumour and anti-oxidative potential of diosgenin against 7, 12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis." 06/01/2011 - "Our results imply that the Chinese medicine sanyaku and the tubers of various yams containing diosgenin as food could be ingested to prevent colon carcinogenesis in humans." 01/01/2009 - "The anticancer mode of action of diosgenin has been demonstrated via modulation of multiple cell signaling events involving critical molecular candidates associated with growth, differentiation, apoptosis, and oncogenesis. " 01/01/2022 - "Additionally, nude mouse tumorigenesis assay was used to further verify the regulatory function of diosgenin on colon cancer. "
4.	Hyperalgesia 01/03/2023 - "The results showed that diosgenin not only protected PC12 from injury, but also reduced the mechanical withdrawal threshold and cold hyperalgesia in OIPN mice. " 04/26/2020 - "There was a significant increase in the tail withdrawal latency of diabetic animals, and mechanical hyperalgesia was significantly alleviated after diosgenin treatment. " 08/01/2017 - "The present study examined the effects of diosgenin on allodynia and the levels of inflammatory mediators in rats following neuropathic pain evoked by chronic constriction injury (CCI). " 02/01/2017 - "This study was designed to study the efficacy of chronic diosgenin administration on alleviation of hyperalgesia in streptozotocin (STZ)-diabetic rats. " 12/13/2022 - "Additionally, oral administration of diosgenin blocked capsaicin-induced thermal hyperalgesia. "
5.	Neuralgia (Stump Neuralgia) 08/01/2017 - "These results implicate diosgenin in the treatment of neuropathic pain, which merits further clinical investigation." 08/01/2017 - "However, the role of diosgenin in neuropathic pain remains unclear. " 08/01/2017 - "Diosgenin attenuates neuropathic pain in a rat model of chronic constriction injury." 02/01/2017 - "This suggests possible therapeutic potential of diosgenin for alleviation and management of diabetic neuropathic pain." 01/03/2023 - "All in all, diosgenin ameliorates peripheral neuropathy and is worthy of further study in the treatment of neuropathic pain."

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