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Dioctyl Sulfosuccinic Acid (DOSS)

All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.
Also Known As:
DOSS; Docusate; Colace; Docusate Sodium; Aerosol OT; Dioctyl Sulfosuccinate; Dioctyl Sulfosuccinic Acid, Ammonium Salt; Dioctyl Sulfosuccinic Acid, Barium Salt; Dioctyl Sulfosuccinic Acid, Calcium Salt; Dioctyl Sulfosuccinic Acid, Magnesium Salt; Dioctyl Sulfosuccinic Acid, Potassium Salt; Dioctyl Sulfosuccinic Acid, Sodium Salt; Dioctylsulfosuccinate; Docusate Calcium; Docusate Potassium; Sodium Bis(2-ethylhexyl)sulfosuccinate; Sodium Dioctyl Sulfosuccinate; Sodium Dioctylsulphosuccinate; Calcium, Docusate; Dioctyl Sulfosuccinate, Sodium; Dioctylsulphosuccinate, Sodium; Potassium, Docusate; Sodium, Docusate; Sulfosuccinates, Dioctyl; Dioctyl Sulfosuccinates
Networked: 69 relevant articles (7 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Cho, Ha Yeon: 3 articles (02/2014 - 06/2011)
2. Kang, Beom Sik: 3 articles (02/2014 - 06/2011)
3. Doss, M O: 3 articles (12/2010 - 03/2000)
4. Poissonnet, Gilles: 2 articles (12/2015 - 10/2014)
5. Santini, José: 2 articles (12/2015 - 10/2014)
6. Chamorey, Emmanuel: 2 articles (12/2015 - 10/2014)
7. Benezery, Karen: 2 articles (12/2015 - 10/2014)
8. Ettaiche, Marc: 2 articles (12/2015 - 10/2014)
9. Haudebourg, Juliette: 2 articles (12/2015 - 10/2014)
10. Riss, Jean-Christophe: 2 articles (12/2015 - 10/2014)

Related Diseases

1. Constipation
2. Neoplasms (Cancer)
05/01/2014 - "Response to letter by Doss: addition of diagnostic CT scan does not increase the cancer risk in patients undergoing SPECT studies."
03/01/2014 - "Adoption of linear no-threshold model violated basic scientific principles and was harmful: Letter from Mohan Doss regarding Edward Calabrese's paper "How the US National Academy of Sciences misled the world community on cancer risk assessment: new findings challenge historical foundations of the linear dose response" (Arch Toxicol (2013) 87:2063-2081) and the letter from Ralph J Cicerone (Arch Toxicol (2014) 88:171-172)."
05/01/2008 - "A comparison of sennosides-based bowel protocols with and without docusate in hospitalized patients with cancer."
09/01/2007 - "We have previously demonstrated that Aerosol OT (AOT)-alginate nanoparticles, a novel formulation developed recently in our laboratory, significantly enhance the therapeutic efficacy of encapsulated drugs like doxorubicin in drug-sensitive tumor cells. "
12/01/2013 - "Key findings include: indwelling pleural catheters and talc pleurodesis provide similar relief of dyspnea in patients with malignant pleural effusions; oxygen many not be needed to prevent dyspnea in many dying patients; docusate may not be needed in addition to sennosides to treat opioid-induced constipation; atropine is no more effective than placebo in treating respiratory rattles in dying patients; many older adult survivors of in-hospital cardiopulmonary resuscitation (CPR) are alive up to 1 year after discharge; observing CPR may decrease family post-traumatic stress; surrogates of intensive care unit patients often interpret prognostic information optimistically; many patients with metastatic cancer feel that chemotherapy may cure their disease; viewing a goals-of-care video may decrease preference for CPR in patients being admitted to skilled nursing facilities. "
3. Infection
4. Delirium
5. Muscle Cramp (Cramp)

Related Drugs and Biologics

1. Psyllium (Metamucil)
2. Methylcellulose (BFL)
3. Laxatives
4. Doxorubicin (Adriamycin)
5. calcium polycarbophil (polycarbophil)
6. 3,3',5,5'-tetramethylbenzidine
7. alginic acid (sodium alginate)
8. DONS
9. Nonoxynol (Nonoxynol 9)
10. Spermatocidal Agents

Related Therapies and Procedures

1. Enema (Enemas)
2. Catheters
3. Pleurodesis
4. Cardiopulmonary Resuscitation (CPR)
5. Thoracotomy