Diminazene

05/01/1996 - "The longer persistence of diminazene in lymph than in plasma may account for the enhanced therapeutic efficacy of diminazene in the early stage, compared with later stages, of a tsetse fly-transmitted trypanosome infection."
01/01/2022 - "Diminazene is an anti-infection agent for animals and is a member of the diarylamidine group. "
01/01/2013 - "Intravital multi-photon microscopy revealed that trypanosomes enter the brain meninges as early as day 5 post-infection but can be killed by diminazene, whereas those that cross the blood-brain barrier and enter the parenchyma by day 21 survived treatment and later caused bloodstream recrudescence. "
05/25/2001 - "vivax infections were susceptible to diminazene. "
02/01/1996 - "Trypanocidal value of liposomal diminazene in experimental Trypanosoma brucei evansi infection in mice."

10/01/2018 - "Stimulation of ACE2/ANG(1-7)/Mas Axis by Diminazene Ameliorates Alzheimer's Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway."
01/01/2023 - "Diminazene Ameliorates Neuroinflammation by Suppression of Astrocytic miRNA-224-5p/NLRP3 Axis in Alzheimer's Disease Model."

10/01/2020 - "Diminazene (DIM) is widely used to treat trypanosomiasis in livestock, but its residues in animal products can cause food safety problems. "
08/01/1991 - "Combination therapy of trypanosomiasis using diminazene and non-steroidal anti-inflammatory drugs."
04/01/1985 - "dose of 2.5 mg/kg followed by 2 mg/kg 24 hr later should be safe and effective in cases of babesiosis and trypanosomiasis sensitive to diminazene. "
01/01/2022 - "Isometamidium chloride is primarily employed in the early stages of trypanosomiasis and resistance is associated with diminazene resistance. "
01/01/2019 - "The data support the continued use of isometamidium following careful dose titration in donkeys and diminazene for trypanosomiasis in equines using the doses and routes of administration reported."

02/01/1988 - "Two died following typical signs of acute babesiosis and a third recovered following diminazene therapy. "
04/01/1985 - "dose of 2.5 mg/kg followed by 2 mg/kg 24 hr later should be safe and effective in cases of babesiosis and trypanosomiasis sensitive to diminazene. "
12/01/2009 - "Diminazene remains one of South Africa's most commonly used antiprotozoal agents for the management of babesiosis in dogs. "
06/01/1996 - "It was concluded that either diminazene or trypan blue can be safely used to treat dogs with clinically mild or moderate, uncomplicated babesiosis. "
06/01/1996 - "To test this, 19 dogs with clinically mild to moderate, uncomplicated babesiosis were placed in low, moderate or high parasitaemia groups, based on venous parasitaemias, and were allotted randomly to diminazene or trypan blue treatment groups. "

07/01/2015 - "Treatment after stroke with systemically applied diminazene resulted in decreased infarct volume and improved neurological function without apparent increases in cerebral blood flow. "
10/01/2017 - "Treatment with diminazene significantly inhibited the expression of casein kinase and lactate dehydrogenase, and reduced infarct size in AMI rats. "
07/01/2015 - "Central infusion of A-779, a Mas receptor antagonist, resulted in larger infarct volumes in diminazene-treated rats, and central infusion of the angiotensin-converting enzyme 2 inhibitor MLN-4760 alone worsened neurological function. "