N,N-Dimethyltryptamine (Dimethyltryptamine)

An N-methylated indoleamine derivative and serotonergic hallucinogen which occurs naturally and ubiquitously in several plant species including Psychotria veridis. It also occurs in trace amounts in mammalian brain, blood, and urine, and is known to act as an agonist or antagonist of certain SEROTONIN RECEPTORS.

Also Known As:

Networked: 68 relevant articles (7 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Frecska, Ede: 5 articles (01/2021 - 01/2016)
2.	Cozzi, Nicholas V: 2 articles (01/2022 - 01/2021)
3.	Bouso, José Carlos: 2 articles (10/2018 - 04/2017)
4.	Dos Santos, Rafael G: 2 articles (10/2018 - 04/2017)
5.	Hallak, Jaime E C: 2 articles (10/2018 - 04/2017)
6.	Barbosa, Paulo Cesar Ribeiro: 2 articles (01/2018 - 07/2012)
7.	Bogenschutz, Michael P: 2 articles (01/2018 - 07/2012)
8.	Szabo, Attila: 2 articles (03/2016 - 01/2016)
9.	Campa, Ana: 2 articles (04/2014 - 07/2013)
10.	Gouzoulis-Mayfrank, E: 2 articles (05/2007 - 11/2005)

Related Diseases

1.	Psychotic Disorders (Schizoaffective Disorder) 04/01/2017 - "Ayahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies." 01/01/2020 - "N,N-Dimethyltryptamine: DMT-induced psychosis." 07/01/2015 - "N,N-Dimethyltryptamine-Induced Psychosis." 06/01/2015 - "On the transmethylation hypothesis: stress, N,N-dimethyltryptamine, and positive symptoms of psychosis." 04/01/2013 - "Recreational use of naturally occurring dimethyltryptamine--contributing to psychosis?"
2.	Treatment-Resistant Depressive Disorder 01/01/2022 - "Randomized placebo-controlled trials have found psilocybin with psychological support effective at treating depression, including treatment-resistant depression; with emergent research also signalling N,N-dimethyltryptamine/ayahuasca also as a potential option for the treatment of depression. " 01/01/2022 - "Ayahuasca/N,N-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD), and psilocybin have evidence supporting their use in depression, and psilocybin and ayahuasca have also shown good results in treatment-resistant depression. " 04/01/2023 - "The use of the psychotomimetic anesthetic, ketamine, for treatment-resistant depression has reawakened the interest in endogenous serotonergic hallucinogens, especially tryptamine and N,N-dimethyltryptamine (DMT), which are beneficial for depression but associated with psychosis.In"
3.	Schizophrenia (Dementia Praecox) 01/01/1974 - "N,N-dimethyltryptamine--a possible relationship to schizophrenia?" 12/01/1973 - "The dimethyltryptamine-forming enzyme in blood platelets: a study in monozygotic twins discordant for schizophrenia." 01/01/1978 - "Disruption of conditioned avoidance behavior by n,n-dimethyltryptamine (DMT) and stereotype by beta-phenylethylamine (PEA): animal models of attentional defects in schizophrenia." 02/01/1976 - "The psychedelic model of schizophrenia: the case of N,N-dimethyltryptamine." 06/01/1979 - "Dimethyltryptamine excretion was greatest in schizophrenia, mania, and "other psychosis" and tended to decline as clinical state improved. "
4.	Substance-Related Disorders (Drug Abuse) 07/01/2012 - "This trend has raised concerns that regular use of this N,N-dimethyltryptamine- and harmala-alkaloid-containing tea may lead to mental and physical health problems associated typically with drug abuse. " 01/01/2018 - "The aims of this study were to assess the impact of ceremonial use of ayahuasca-a psychedelic brew containing N,N-dimethyltryptamine (DMT) and β-carboline -and attendance at União do Vegetal (UDV) meetings on substance abuse; here we report the findings related to alcohol and tobacco use disorder. " 10/17/2018 - "In the past decade, an increasing number of clinical trials are reporting evidence that psychedelics or serotonergic hallucinogens (such as lysergic acid diethylamide, psilocybin, and ayahuasca/dimethyltryptamine) could be effective in the treatment of mood, anxiety, and substance use disorders. "
5.	Major Depressive Disorder (Major Depressive Disorders) 01/01/2022 - "Exploratory study of the dose-related safety, tolerability, and efficacy of dimethyltryptamine (DMT) in healthy volunteers and major depressive disorder." 09/14/2023 - "The psychedelic N,N- dimethyltryptamine (DMT) is in clinical development for the treatment of major depressive disorder. " 05/01/2023 - "N,N-dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). "

Related Drugs and Biologics

1.	Hallucinogens (Psychedelics)
2.	Psilocybin (Psilocibin)
3.	Lysergic Acid Diethylamide (LSD)
4.	Ketamine
5.	tryptamine
6.	Selenium Compounds
7.	Anesthetics (Anesthetic Agents)
8.	Amines
9.	Sigma-1 Receptor
10.	1,7- N- heptylene- bis- 9,9'- amino- 1,2,3,4- tetrahydroacridine