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Dimethylallyltranstransferase (Dimethylallyltransferase)

An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to yield pyrophosphate and geranylpyrophosphate. The enzyme then catalyzes the condensation of the latter compound with another molecule of isopentenyl pyrophosphate to yield pyrophosphate and farnesylpyrophosphate. EC 2.5.1.1.
Also Known As:
Dimethylallyltransferase; Prenyltransferase; Dolichyl Phosphate Synthetase; Geranylgeranyl Pyrophosphate Synthetase; Nerylpyrophosphate Synthetase; Phosphate Synthetase, Dolichyl; Pyrophosphate Synthetase, Geranylgeranyl; Synthetase, Dolichyl Phosphate; Synthetase, Farnesylpyrophosphate; Synthetase, Geranylgeranyl Pyrophosphate; Synthetase, Geranylpyrophosphate; Synthetase, Nerylpyrophosphate; Farnesylpyrophosphate Synthetase; Geranylpyrophosphate Synthetase; Dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyl (trans) transferase
Networked: 21 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Distefano, Mark D: 2 articles (01/2015 - 01/2014)
2. Cengel, Keith A: 2 articles (09/2005 - 08/2005)
3. McKenna, W Gillies: 2 articles (09/2005 - 08/2005)
4. Palsuledesai, Charuta C: 1 article (01/2015)
5. Lockless, Steve W: 1 article (07/2014)
6. Bai, Yonghong: 1 article (07/2014)
7. Huang, Hua: 1 article (07/2014)
8. Levin, Elena J: 1 article (07/2014)
9. Zhou, Ming: 1 article (07/2014)
10. Liu, Shian: 1 article (07/2014)

Related Diseases

1. Neoplasms (Cancer)
2. Parasitic Diseases (Parasitic Disease)
3. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
4. Infection
5. Prostatic Neoplasms (Prostate Cancer)

Related Drugs and Biologics

1. Dimethylallyltranstransferase (Dimethylallyltransferase)
2. Enzymes
3. Cholesterol
4. glyceollin
5. p38 Mitogen-Activated Protein Kinases
6. Small Interfering RNA (siRNA)
7. rho GTP-Binding Proteins (rho GTP-Binding Protein)
8. CD95 Antigens (fas Receptor)
9. NF-kappa B (NF-kB)
10. Vitamins

Related Therapies and Procedures

1. Therapeutics
2. Heterologous Transplantation (Xenotransplantation)
3. Castration