Dimethisterone

A synthetic progestational hormone without significant estrogenic or androgenic properties. It was formerly used as the progestational component in SEQUENTIAL ORAL CONTRACEPTIVE AGENTS .

Also Known As:

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Adenocarcinoma 10/01/1969 - "Effects of dimethisterone on endometrial adenocarcinoma--electron microscopic study." 02/01/1972 - "Palliation of metastatic endometrial adenocarcinoma with dimethisterone." 08/23/1976 - "Although these cases do not prove that long-term administration of dimethisterone-ethinyl estradiol causes endometrial adenocarcinoma or atypia, they indicate that it may do so."
2.	Endometrial Neoplasms (Endometrial Cancer) 01/01/1980 - " Cases of endometrial cancer have been observed in women using sequential oral contraceptives, particularly dimethisterone with ethinylestradiol, but a cause-and-effect relationship has not been established. " 03/06/1980 - " Women who had taken Oracon (0.1 mg of ethinyl estradiol and 25 mg of dimethisterone) were estimated to have a risk of endometrial cancer of 7.3 times that of other women (P=0.007). " 03/06/1980 - "Women who had taken Oracon (0.1 mg of ethinyl estradiol and 25 mg of dimethisterone) were estimated to have a risk of endometrial cancer 7.3 times that of other women (P = 0.007). " 11/01/1980 - " Endometrial carcinoma has been reported to be associated with estrone sulfate therapy but not with combined estrogen-progesterone OCs; however, Silverberg and Makowski reported several cases of endometrial carcinoma associated with the use of the sequential OC Oracon, a product containing dimethisterone. "
3.	Endometrial Hyperplasia 09/01/1977 - "The major findings included cystic endometrial hyperplasia and pyometra requiring hysterectomies and alopecia for the norethindrone-ethynylestradiol and dimethisterone-ethynylestradiol treated dogs. " 09/01/1977 - " The major findings included cystic endometrial hyperplasia and pyometra requiring hysterectomies and alopecia for the norethindrone-ethinyl estradiol and dimethisterone-ethinyl estradiol treated dogs. " 07/01/1984 - " Oracon was different from other sequentials in that it contained a large amount of estrogen, 100 mcg of ethinyl estradiol, with only a weak progestin, 25 mg of dimethisterone, too little to reverse estrogen-induced endometrial hyperplasia. "
4.	Pyometra 09/01/1977 - "The major findings included cystic endometrial hyperplasia and pyometra requiring hysterectomies and alopecia for the norethindrone-ethynylestradiol and dimethisterone-ethynylestradiol treated dogs. " 09/01/1977 - " The major findings included cystic endometrial hyperplasia and pyometra requiring hysterectomies and alopecia for the norethindrone-ethinyl estradiol and dimethisterone-ethinyl estradiol treated dogs. "
5.	Metrorrhagia (Spotting) 04/07/1969 - "A request for suggestions in management of a 38-year-old woman in good health suffering breakthrough bleeding after 3 years of therapy on ethinyl estradiol plus dimethisterone with ethinyl estradiol (Oracon) for the control of heavy menstrual flow elicited the following response. "

Related Drugs and Biologics

1.	Ethinyl Estradiol (Estinyl)
2.	Oracon
3.	Estrogens (Estrogen)
4.	Progesterone
5.	Progestins (Progestagens)
6.	Norethindrone (Norethisterone)
7.	Sequential Oral Contraceptives
8.	estrone sulfate (Evex)

Related Therapies and Procedures

1.	Therapeutics
2.	Hysterectomy