|1.||O'Doherty, George A: 4 articles (02/2016 - 01/2012)|
|2.||Greupink, Rick: 3 articles (12/2014 - 02/2013)|
|3.||Russel, Frans G M: 3 articles (12/2014 - 02/2013)|
|4.||Gozalpour, Elnaz: 3 articles (12/2014 - 02/2013)|
|5.||Koenderink, Jan B: 3 articles (12/2014 - 02/2013)|
|6.||Stueckle, Todd A: 3 articles (03/2014 - 01/2012)|
|7.||Rojanasakul, Yon: 3 articles (03/2014 - 01/2012)|
|8.||Dinu, Cerasela Zoica: 3 articles (03/2014 - 01/2012)|
|9.||Helber, Izo: 3 articles (07/2013 - 11/2009)|
|10.||Tucci, Paulo J F: 3 articles (07/2013 - 11/2009)|
01/01/1957 - "A clinical study with acetyl-digitoxin, a new digitalis drug, for the treatment of congestive heart failure."
02/01/1953 - "Studies on the renal excretion of radioactive digitoxin in human subjects with cardiac failure."
05/01/2015 - "Using electrochemical luminescens immunoassay (ECLIA) compounds equivalent to digitoxin were detected in the blood sample confirming the absorption of toad poison components from the intestines into the circulation potentially leading to cardiac failure. "
04/01/2011 - "The cardiac glycoside digitoxin, consisting of a steroid core linked to a labile trisaccharide, has been used for centuries for the treatment of congestive heart failure. "
11/01/2009 - "We analyzed whether digitoxin affects the survival of rats with congestive heart failure. "
01/30/1998 - "In this paper three cases of severe poisoning with digitoxin with maximal S-digitoxin levels of 115, 150 and 239 nmol/l are described. "
10/01/1997 - "Rapid detection of oleander poisoning using fluorescence polarization immunoassay for digitoxin. "
01/01/1992 - "Based on these results, determination of digitoxin levels in the choroid-retina could contribute to improving postmortem diagnosis of lethal digitoxin poisoning."
01/01/1992 - "Postmortem digitoxin levels in the choroid-retina and vitreous humor of patients who had undergone digitoxin therapy (therapeutic group) and in one case of suicidal digitoxin poisoning were measured and compared with levels in femoral vein blood, myocardium, kidney and liver. "
04/01/1991 - "In an effort to solve this problem, red blood cell K+ was measured by atomic absorption spectrophotometry and plasma digitoxin concentration assayed in six patients admitted to an intensive care unit after digitoxin self-poisoning. "
01/01/2012 - "In this study, NCI-H460 cells were treated with digitoxin and a synthetic analog D6-MA to determine their anti-cancer activity. "
11/01/2005 - "Several analogues of digitoxin (1) were evaluated for growth inhibition activity in three human cancer cell lines; this study showed that digitoxin (1) was the most active compound and revealed some structural features that may play a role in the growth inhibition activity of these drugs. "
01/01/2001 - "Digitoxin medication and cancer; case control and internal dose-response studies."
09/15/2014 - "By developing structure-function combinatorial relations we showed that digitoxin targets cancer cells in a time and dose-dependant manner by activating pro-apoptotic and anti-proliferative signaling cascades that results in strengthening cellular adhesion and sequestration of key regulatory proliferation protein from the nucleus. "
09/15/2014 - "In this research we used a combinatorial approach to evaluate the anti-cancer mechanisms of digitoxin in real-time. "
|4.||Breast Neoplasms (Breast Cancer)
01/01/2010 - "Our studies show the potential of digitoxin to prevent and treat breast cancer and indicate that the combination of digitoxin and paclitaxel is a promising treatment for ER negative breast cancer. "
01/01/2010 - "Digitoxin activates EGR1 and synergizes with paclitaxel on human breast cancer cells."
01/01/2010 - "Paclitaxel, as well as digitoxin, inhibited the in vitro activity of the purified Na(+)-K(+)-ATPase; digitoxin enhanced the growth inhibitory effects of paclitaxel on Her2 overexpressing breast cancer cells. "
10/31/2008 - "Actein's inhibition of Na+-K+-ATPase activity was less potent than that of digitoxin, but actein potentiated digitoxin's inhibitory effect on Na+-K+-ATPase activity and MDA-MB-453 breast cancer cell growth. "
10/31/2008 - "Actein inhibits the Na+-K+-ATPase and enhances the growth inhibitory effect of digitoxin on human breast cancer cells."
|5.||Liver Cirrhosis (Hepatic Cirrhosis)
04/01/1993 - "Digitoxin and its metabolites in patients with liver cirrhosis."
07/01/1978 - "The metabolism of digitoxin in hepatic cirrhosis of human subjects."
01/01/1978 - "[Pharmacokinetics of digitoxin in patients with liver cirrhosis]."
04/01/1993 - "In conclusion, hydrolysis of digitoxin is altered in liver cirrhosis, whereby a significant reduction in the renal clearance and urinary recovery of digitoxigenin-mono-digitoxoside and digitoxigenin was seen in the present study."
04/01/1993 - "Pharmacokinetic profile and urinary excretion of digitoxin and 4 metabolites were investigated in 9 patients with biopsy confirmed liver cirrhosis (median antipyrine clearance 20.0 +/- 5.4 ml/min; X +/- SEM) and were compared with that of 8 healthy volunteers (antipyrine clearance 36.9 +/- 4.9 ml/min) following intravenous and p.o. "
|8.||Neurotransmitter Agents (Neurotransmitter)
|2.||Drug Therapy (Chemotherapy)