|1.||Kreis, Wolfgang: 1 article (10/2015)|
|2.||Nolte, Elke: 1 article (10/2015)|
|3.||Hertlein, Heidi: 1 article (10/2015)|
|4.||Taubert, Helge: 1 article (10/2015)|
|5.||Wullich, Bernd: 1 article (10/2015)|
|6.||Ebert, Nadja: 1 article (10/2015)|
|7.||Wach, Sven: 1 article (10/2015)|
|8.||Sobel, Anna: 1 article (10/2015)|
|9.||Slany, Robert: 1 article (10/2015)|
|10.||Müller-Uri, Frieder: 1 article (10/2015)|
|1.||Liver Cirrhosis (Hepatic Cirrhosis)
01/01/2013 - "C3'/C4'-Stereochemical Effects of Digitoxigenin α-L-/α-D-Glycoside in Cancer Cytotoxicity."
09/01/2014 - "Four compounds from this series (5 and 7-9, IC50 values ranging from 0.01 to 0.07μM) exhibited cytotoxicity against three of the cancer cell lines assayed that was similar to or higher than the well-known therapies digoxin and digitoxigenin. "
04/01/2011 - "For the cancer cell viability assay the shortest mimics were found to have highest efficacy, with the best ligand having a monoethylene glycol unit (IC(50) 0.24 μM), which was slightly better than digitoxigenin (IC(50) 0.64 μM), while none of the novel cardiac glycoside mimics display an in vitro effect as high as digitoxin (IC(50) 0.02 μM)."
06/01/2001 - "The saponin digitonin, the aglycone digitoxigenin and five cardiac glycosides were evaluated for cytotoxicity using primary cultures of tumor cells from patients and a human cell line panel (representing different cytotoxic drug-resistance patterns). "
10/01/2015 - "The New Semisynthetic Cardenolide Analog 3β-[2-(1-Amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) Efficiently Suppresses Cell Growth in Human Leukemia and Urological Tumor Cell Lines."
10/01/2015 - "The aim of the present study was to characterize the cytotoxic effects of the new semisynthetic cardenolide analog AMANTADIG (3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin), and the cardenolide digitoxin on leukemia and urological tumor cell lines. "
08/01/1980 - "Regional brain 3H-digitoxigenin and monoamine content during the development of convulsions produced by system digitoxigenin."
08/04/1978 - "Seizures were frequently induced by digitoxigenin when the [K+]0 baseline was only slightly elevated, and the occurrence of seizures was not associated with a definable threshold level of [K+]0. "
01/01/1982 - "The pretreatments did not alter the frequency of the discharges but reduced their amplitude to 0.4 -0.75 mV. The results suggest a role for monoamines, and in particular serotonin, in the effect of digitoxigenin to cause hippocampal seizure discharge."
01/01/1962 - "[Effect of intracerebrally injected biogenic amines on digitoxigenin convulsions in mice]."
08/26/1985 - "Intravenous administration of digitoxigenin (DTXGN) evokes seizure episodes in mice which may be dependent on brain biogenic amines such as serotonin (5-HT). "
|2.||Ethylene Glycol (Monoethylene Glycol)
|5.||Serotonin (5 Hydroxytryptamine)
|7.||Biogenic Amines (Biogenic Amine)
|8.||Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)