Diethylstilbestrol (Stilbestrol)

A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)

Also Known As:

Networked: 1652 relevant articles (33 outcomes, 143 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Palmer, Julie R: 22 articles (10/2021 - 10/2002)
2.	Troisi, Rebecca: 22 articles (10/2021 - 10/2002)
3.	Hatch, Elizabeth E: 21 articles (10/2021 - 10/2002)
4.	Hoover, Robert N: 17 articles (10/2021 - 10/2002)
5.	Herbst, Arthur L: 15 articles (01/2017 - 10/2002)
6.	Robboy, Stanley J: 13 articles (01/2019 - 01/2005)
7.	Titus-Ernstoff, Linda: 13 articles (02/2014 - 10/2002)
8.	Hyer, Marianne: 12 articles (10/2021 - 03/2003)
9.	Strohsnitter, William C: 12 articles (10/2021 - 07/2007)
10.	Adam, Ervin: 12 articles (01/2019 - 03/2003)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 02/01/2013 - "The purpose of this study was to assess the efficacy and safety of low-dose (1 mg) daily diethylstilbestrol (DES) for the treatment of castrate-resistant prostate cancer (CRPC). " 06/01/1986 - "As far as prostatic cancer is concerned, data coming from comparative trials show that MPA is less effective than diethylstilbestrol (DES), and therefore should not be considered the first choice for previously untreated patients. " 02/01/1976 - "This study was undertaken to determine the effects of DES (diethylstilbestrol) on prostatic neoplasms and of different dosage levels on the pituitary-gonadal axis. " 02/01/1962 - "A cooperative group study of prostatic cancer: stilbestrol versus placebo in advanced progressive disease." 05/01/2013 - "Diethylstilbestrol (DES) has a direct cellular mechanism inhibition on prostate cancer. "
2.	Neoplasms (Cancer) 01/01/1981 - "Tumors grown in hypophysectomized, orchiectomized, adrenalectomized, or diethylstilbestrol-treated animals showed a significant reduction in the proportion of mid-S phase cells as compared with controls. " 06/08/2006 - "In the present study, we investigated HLTF expression by immunohistochemistry in a model of kidney tumors induced by continuous administration of diethylstilbestrol to male Syrian golden hamsters. " 08/01/2005 - "This study explores in what ways the genotoxic, cytotoxic and apoptotic effects of diethylstilbestrol (DES), a chemical agent currently used in the treatment of various types of cancer, on the human lymphocytes depend upon the dose and the exposure time. " 09/01/2002 - "Experimental animal and clinical studies have well established the association of prenatal exposure to diethylstilbestrol (DES) and the subsequent development of reproductive tract abnormalities, including poor reproductive outcome and neoplasia. " 10/01/2000 - "This study evaluated the long-term risk of developing high-grade squamous neoplasia of the genital tract among women exposed prenatally to diethylstilbestrol.METHODS: A cohort comprising 3899 DES-exposed and 1374 unexposed daughters was followed for thirteen years (1982-1995) for pathology-confirmed diagnoses of high-grade squamous neoplasia. "
3.	Carcinoma (Carcinomatosis) 01/01/2017 - "The aim of this study was to summarize the clinical and pathological characteristics and to conduct prognosis analysis of patients who were diagnosed with clear cell carcinoma of the uterine cervix (CCCUC) and without a history of exposure to diethylstilbestrol. " 05/01/2014 - "Non-diethylstilbestrol-associated primary clear cell carcinoma of the vagina: two case reports with immunohistochemical studies and literature review." 10/01/1981 - "Since 1971 several studies have reported the appearance of clear-cell carcinoma and clear-cell cervical carcinoma in young women exposed prenatally to diethylstilbestrol (DES). " 01/01/1975 - "In the second study, diethylstilbestrol given in a dose of 1.0 mg/day has been as effective as the 5.0-mg dose in controlling the prostatic carcinoma but has been associated with a lower incidence of cardiovascular deaths. " 08/01/2021 - "A Rare Case of Clear Cell Cervical Carcinoma to a Woman, 50 Years After Diethylstilbestrol Exposure for Lactation Suppression."
4.	Breast Neoplasms (Breast Cancer) 01/01/1963 - "[A CASE OF BREAST CANCER OF LONG DURATION "CURED" WITH STILBESTROL]." 10/01/1996 - "These findings are consistent with those of several other studies of diethylstilbestrol exposure and breast cancer." 10/01/1996 - "The age of study participants did not modify the association between exposure and breast cancer, and there were no significant interactions between ever use of diethylstilbestrol and any of the other potential risk factors included in the analysis. " 10/01/2018 - "Background: Prenatal diethylstilbestrol (DES) exposure is associated with adverse reproductive outcomes and cancer of the breast and vagina/cervix in adult women. " 01/01/2018 - "In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. "
5.	Adenocarcinoma 07/01/1986 - "This paper reports on a study of four cases of primary adenocarcinoma (including one with in utero diethylstilbestrol exposure) of the vagina from the files of the Medical University of South Carolina. " 06/01/1980 - "A study was done on 30 patients with advanced adenocarcinoma of the prostate treated with diethylstilbestrol. " 10/01/2023 - "We used a mouse model of endometrial adenocarcinoma that results from brief developmental exposure to an estrogenic chemical, diethylstilbestrol (DES), to determine causative factors. " 08/01/2023 - "Clear cell type vaginal adenocarcinoma is most associated with exposure to diethylstilbestrol (DES) in-utero. " 05/01/2022 - "Vaginal adenocarcinomas are most frequently a metastatic lesion, and less commonly, have clear cell histology and occur in young women with diethylstilbestrol (DES) exposure in utero. "

Related Drugs and Biologics

1.	Hormones (Hormone)
2.	Estradiol Congeners (Synthetic Estrogens)
3.	Leuprolide (Lupron)
4.	Estrogens (Estrogen)
5.	Phosphates (Orthophosphate)
6.	Estramustine
7.	Androgens
8.	Gonadotropin-Releasing Hormone (GnRH)
9.	Tamoxifen
10.	Estradiol (Delestrogen)

Related Therapies and Procedures

1.	Therapeutics
2.	Orchiectomy (Orchidectomy)
3.	Drug Therapy (Chemotherapy)
4.	Castration
5.	Oral Administration