An alpha adrenergic antagonist.
Also Known As:
Dibenzyl Chlorethylamine; Chlorethylamine, Dibenzyl; Dibenamine; Benzenemethanamine, N-(2-chloroethyl)-N-(phenylmethyl)-
Networked: 55 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Katori, Makoto: 1 article (02/2008)
2. Majima, Masataka: 1 article (02/2008)
3. Yang, Shi-Jie: 1 article (02/2008)

Related Diseases

1. Cardiac Arrhythmias (Arrythmia)
2. Hemorrhagic Shock
11/01/1952 - "Effect of dibenamine on renal blood flow in hemorrhagic shock."
08/01/1950 - "Impending hemorrhagic shock and the course of events following administration of dibenamine."
01/01/1947 - "The effect of dibenamine on the production of irreversible hemorrhagic shock."
12/01/1989 - "The studies on the mechanism of action indicate that the ACTH-induced reversal of hemorrhagic shock (a) is an extra-hormonal, adrenal-independent effect, because it is not affected by adrenalectomy and is shared by many ACTH-fragments practically devoid of corticotropic activity; (b) is antagonized by morphine in a surmontable way; (c) needs the functional integrity of the sympathetic nervous system (it is prevented by guanethidine, reserpine, and clonidine) and the availability of peripheral alpha-adrenoceptors (it is antagonized by dibenamine, prazosin and yohimbine, but not by practolol); (d) requires the integrity of afferent vagal fibers (it is almost completely abolished by vagotomy); (e) involves central cholinergic networks (it is antagonized by atropine sulphate, but not by atropine methyl bromide; and it is prevented by the intracerebroventricular injection of hemicholinium-3); (f) is associated with a massive increase in the volume of circulating blood, likely due to a mobilization from peripheral pooling sites (it is largely prevented by splenectomy or by suprahepatic veins ligature, and is associated with a restoration of the venous blood flow in peripheral vascular beds and with a normalization of venous PO2); (g) is associated with a restoration of heart and spleen adrenoceptors, whose number is significantly decreased during hemorrhagic shock. "
3. Shock
4. Glaucoma
5. Anoxia (Hypoxia)

Related Drugs and Biologics

1. Epinephrine (Adrenaline)
2. cyclopropane
3. Atropine (Hyoscyamine)
4. Reserpine (Serpasil)
5. Prazosin (Minipress)
6. Morphine (MS Contin)
7. Guanethidine
8. Yohimbine (Yocon)
9. Adrenergic Receptors (Adrenergic Receptor)
10. Practolol

Related Therapies and Procedures

1. Adrenalectomy
2. Vagotomy
3. Splenectomy
4. Ligation
5. Tourniquets