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Diamfenetide
Anthelmintic. It has been shown to be useful in fasciola infections in sheep.
Also Known As:
Acemidophen; Coriban; Di-(2-(4-acetamidophenoxy)ethyl) Ether; Diamphenethide; Acetamide, N,N'-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bis-
Networked:
16
relevant articles (
5
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Aniline Compounds: 46
Anilides: 22
Acetanilides: 7
Diamfenetide: 16
bis(beta-(4-aminophenoxy)ethyl) ether
Amides: 2428
Anilides: 22
Acetanilides: 7
Diamfenetide: 16
bis(beta-(4-aminophenoxy)ethyl) ether
Related Diseases
1.
Infections
02/01/1980 - "
Small doses of diamfenetide given daily were effective in preventing the establishment of F hepatica infections in ruminants.
"
02/16/1985 - "
Groups of eight Welsh Mountain sheep were dosed with diamphenethide at the rate of 70 mg/kg bodyweight at either one, four, six or eight weeks after artificial infection with approximately 300 Fasciola hepatica metacercariae.
"
08/01/1984 - "
Sheep with potentially fatal Fasciola hepatica burdens were treated with diamphenethide 4, 8 or 12 weeks after infection.
"
08/01/1984 - "
Productivity in sheep treated with diamphenethide at different times after infection with Fasciola hepatica.
"
01/01/1975 - "
Development of host resistance to Fasciola hepatica after the elimination of primary infection with diamphenethide.
"
2.
Fascioliasis
11/05/1976 - "
[Efficacy of Coriban and Disto-5-Cogla in fascioliasis and paramphistomians of domestic ruminants].
"
02/16/1985 - "
The systematic use of diamphenethide at this dose level at intervals of up to six weeks during the period of metacercarial challenge should prevent ovine fascioliasis.
"
01/15/1978 - "
The activity of diamphenethide against natural infestations of Fasciola hepatica in fattening lambs was assessed on a farm with a noted history of fascioliasis.
"
12/14/1974 - "
Diamphenethide in prophylaxis of ovine fascioliasis.
"
02/01/1980 - "
In limited trials against experimentally induced Fasciola hepatica infections, diamfenetide (N,N'-[oxybis(2,1-ethanediyloxy-4,1-phenylene)]bisacetamide) showed potential value for the prevention of acute fascioliasis in sheep and cattle.
"
3.
Chronic Disease (Chronic Diseases)
01/15/1978 - "
A single treatment with diamphenethide at 110 mg/kg bodyweight given when the sheep were removed from the trial area was 96.7% effective against the sub-chronic disease which had developed by this time.
"
4.
Body Weight (Weight, Body)
06/01/1975 - "
Diamphenethide at a dosage rate of 100 mg/kg body weight was found 99.4 per cent effective.
"
02/01/1980 - "
When given at a dosage of 10 mg/kg of body weight, diamfenetide was 87% effective in preventing establishment of F hepatica infections in sheep that were given the drug daily for 14 days, and was 96% effective in sheep that were given the drug for 21 days.
"
5.
Reinfection
01/01/1975 - "
We studied the specificity of the individual developmental stages of Fasciola hepatica for evoking immune response of the host to reinfection with this parasite, whereby the primary infection was eliminated by a dose of 150 mg/kg diamphenethide administered in various intervals.
"
Related Drugs and Biologics
1.
Diamfenetide
2.
Rafoxanide
3.
Anthelmintics
4.
Amines
5.
Solvents
6.
Salicylanilides
7.
Phenols
8.
Enzymes
9.
Carbon Tetrachloride (Tetrachloromethane)
10.
Ethanol (Ethyl Alcohol)
Related Therapies and Procedures
1.
Chemoprevention