02/01/1980 - "Small doses of diamfenetide given daily were effective in preventing the establishment of F hepatica infections in ruminants."
02/16/1985 - "Groups of eight Welsh Mountain sheep were dosed with diamphenethide at the rate of 70 mg/kg bodyweight at either one, four, six or eight weeks after artificial infection with approximately 300 Fasciola hepatica metacercariae. "
08/01/1984 - "Sheep with potentially fatal Fasciola hepatica burdens were treated with diamphenethide 4, 8 or 12 weeks after infection. "
08/01/1984 - "Productivity in sheep treated with diamphenethide at different times after infection with Fasciola hepatica."
11/01/1974 - "The anthelmintic activity of diamphenethide against immature Fasciola hepatica in goats and the course of experimental infections as demonstrated by plasma enzyme changes."
11/05/1976 - "[Efficacy of Coriban and Disto-5-Cogla in fascioliasis and paramphistomians of domestic ruminants]."
02/16/1985 - "The systematic use of diamphenethide at this dose level at intervals of up to six weeks during the period of metacercarial challenge should prevent ovine fascioliasis."
12/14/1974 - "Diamphenethide in prophylaxis of ovine fascioliasis."
02/01/1980 - "In limited trials against experimentally induced Fasciola hepatica infections, diamfenetide (N,N'-[oxybis(2,1-ethanediyloxy-4,1-phenylene)]bisacetamide) showed potential value for the prevention of acute fascioliasis in sheep and cattle. "
11/11/1972 - "Experimentally-produced acute fascioliasis in sheep: a further trial with rafoxanide and diamphenethide."
|3.||Body Weight (Weight, Body)
06/01/1975 - "Diamphenethide at a dosage rate of 100 mg/kg body weight was found 99.4 per cent effective. "
02/01/1980 - "When given at a dosage of 10 mg/kg of body weight, diamfenetide was 87% effective in preventing establishment of F hepatica infections in sheep that were given the drug daily for 14 days, and was 96% effective in sheep that were given the drug for 21 days. "
04/01/1983 - "Short-term (1-3 hr) incubations in vitro of immature and adult Fasciola hepatica with 10(-4) to 10(-5) M free amine of diamfenetide (DPT-FA) demonstrated a time/dose-dependent, irreversible paralysis that involved an increase in muscular tension and decrease in contraction amplitude. "
01/01/1988 - "At a concentration of 1 x 10(-4) M (28.84 micrograms/ml), with a solvent concentration of 1.0% (v/v) ethanol, the deacetylated (amine) metabolite of diamphenethide (DAMD) causes an initial stimulation of activity, followed by suppression, leading to a paralysis within 3 h. "
06/01/1984 - "Brotianide and the deacetylated metabolite of diamphenethide cause a rapid flaccid paralysis of the fluke at concentrations of 1.0 micrograms/ml and above. "
06/01/1984 - "Carbon tetrachloride and diamphenethide do not affect movement at concentrations up to 500 and 100 micrograms/ml, respectively; at 1000 micrograms/ml, however, carbon tetrachloride induces a rapid tonic paralysis. "
09/01/1999 - "In particular, a number of fasciolicides-salicylanilides, phenols, diamphenethide-induce a rapid paralysis of the fluke, so their action may have a neuromuscular basis, although the actions remain ill-defined. "
|5.||Carbon Tetrachloride (Tetrachloromethane)
|6.||Ethanol (Ethyl Alcohol)