Diabetic Neuropathies (Diabetic Neuropathy)

1751  relevant articles (198 outcomes, 303 trials/studies) found for this Disease

Diabetic Neuropathy; Neuropathy, Diabetic; Diabetic Amyotrophy; Diabetic Polyneuropathy; Asymmetric Diabetic Proximal Motor Neuropathy; Diabetic Asymmetric Polyneuropathy; Diabetic Mononeuropathy; Diabetic Mononeuropathy Simplex; Diabetic Neuropathy, Painful; Mononeuropathy, Diabetic; Symmetric Diabetic Proximal Motor Neuropathy; Amyotrophies, Diabetic; Amyotrophy, Diabetic; Asymmetric Polyneuropathies, Diabetic; Asymmetric Polyneuropathy, Diabetic; Autonomic Neuropathies, Diabetic; Autonomic Neuropathy, Diabetic; Diabetic Amyotrophies; Diabetic Asymmetric Polyneuropathies; Diabetic Autonomic Neuropathies; Diabetic Mononeuropathies; Diabetic Mononeuropathy Simplices; Diabetic Neuralgias; Diabetic Neuropathies, Painful; Diabetic Polyneuropathies; Mononeuropathies, Diabetic; Mononeuropathy Simplex, Diabetic; Mononeuropathy Simplices, Diabetic; Neuralgias, Diabetic; Neuropathies, Diabetic; Neuropathies, Diabetic Autonomic; Neuropathies, Painful Diabetic; Neuropathy, Diabetic Autonomic; Neuropathy, Painful Diabetic; Painful Diabetic Neuropathies; Painful Diabetic Neuropathy; Polyneuropathies, Diabetic; Polyneuropathies, Diabetic Asymmetric; Polyneuropathy, Diabetic; Polyneuropathy, Diabetic Asymmetric; Simplex, Diabetic Mononeuropathy; Simplices, Diabetic Mononeuropathy; Diabetic Autonomic Neuropathy; Diabetic Neuralgia; Neuralgia, Diabetic

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Postherpetic Neuralgia
3.	Neuralgia (Stump Neuralgia)
4.	Diabetic Neuropathies (Diabetic Neuropathy)
5.	Migraine Disorders (Migraine)
244 Diseases and 574 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Sima, Anders A F: 8 articles (01/2008 - 03/2003)
2.	Tomlinson, David R: 7 articles (01/2008 - 01/2002)
3.	Obrosova, Irina G: 5 articles (06/2007 - 03/2004)
4.	Sharma, Shyam S: 4 articles (03/2008 - 01/2005)
5.	Zhang, Weixian: 4 articles (01/2008 - 03/2003)
6.	Dellon, A Lee: 4 articles (03/2007 - 09/2002)
7.	Ziegler, Dan: 4 articles (11/2006 - 03/2003)
8.	Zotova, E V: 4 articles (02/2006 - 01/2001)
9.	Nosikov, V V: 4 articles (02/2006 - 01/2001)
10.	Stevens, Martin J: 4 articles (12/2005 - 08/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Diabetic Neuropathies:

1.	Aldehyde Reductase (Aldose Reductase)IBA 09/01/1997 - "Despite numerous attempts over 16 years, the results of aldose reductase inhibitor (ARI) trials for the treatment of diabetic neuropathy have not proven efficacy" 05/01/2006 - "Aldose reductase pathway inhibition improved vascular and C-fiber functions, allowing for pressure-induced vasodilation restoration during severe diabetic neuropathy." 06/01/2001 - "Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy." 09/01/1998 - "Effects of the aldose reductase inhibitor on diabetic polyneuropathy--the efficacy of F wave measurement]" 01/01/1994 - "The clinical efficacy of an aldose reductase (AR) inhibitor in diabetic polyneuropathy depends on its bioavailability at the site(s) of AR in peripheral nerves" Get all the results and reference details, order at left...
2.	gabapentin (Neurontin)FDA LinkGeneric 03/05/1999 - "Gabapentin displays efficacy against abnormal sensory processing in diabetic rats and may be of benefit for treating painful diabetic neuropathy." 05/01/2005 - "Based on the reviewed randomised controlled trials, gabapentin shows good efficacy, a favourable side-effect profile with lack of drug interactions and therefore it may be a first choice treatment in painful diabetic neuropathy, especially in the elderly" 01/01/2001 - "Studies have also shown gabapentin to be effective and well tolerated in the treatment of diabetic neuropathy" 02/01/1999 - "Gabapentin in the treatment of painful diabetic neuropathy: a placebo controlled, double blind, crossover trial." 03/01/2007 - "CONCLUSIONS: The lack of negative effects on quality of life, the better compliance, and the comparable efficiency of SSRIs suggest that these drugs may be considered as alternative to gabapentin in painful diabetic neuropathy." Get all the results and reference details, order at left...
3.	Thioctic Acid (Lipoic Acid)IBA 06/01/2008 - "Alpha-lipoic acid (LA), a potent antioxidant, has been shown to be an effective treatment for diabetic neuropathy when given intravenously" 01/01/2007 - "Thioctic acid (-lipoic acid) is another substance known to enhance energy metabolism in mitochondria and to be beneficial in diabetic neuropathy" 07/01/2005 - "Moreover, given the potential role of oxidative stress in the pathogenesis of secondary complications in diabetes, alpha-lipoic acid might be beneficial in the prevention/treatment of these complications as was recently shown for diabetic neuropathy." 12/01/2000 - "Lipoic acid supplementation has been found to be beneficial in preventing neurovascular abnormalities in diabetic neuropathy" 01/01/1999 - "Here we review the current evidence from the clinical trials that assessed the therapeutic efficacy and safety of thioctic acid in diabetic polyneuropathy" Get all the results and reference details, order at left...
4.	Capsaicin (Zostrix)IBA 11/01/1991 - "Study results suggest that topical capsaicin cream is safe and effective in treating painful diabetic neuropathy." 06/01/1991 - "The results of this study indicate that topical capsaicin 0.075% cream is safe and effective in managing painful diabetic neuropathy." 01/01/2002 - "In the present study, we first examined the role of capsaicin-sensitive C-fibers in the development of allodynia induced by diabetic neuropathy" 01/01/1992 - "OBJECTIVE--We conducted an 8-wk controlled study with topical 0.075% capsaicin in subjects with chronic severe painful diabetic neuropathy who were unresponsive or intolerant to conventional therapy" 01/01/1992 - "RESEARCH DESIGN AND METHODS--We examined the effects of topical 0.075% capsaicin cream on thermal and vibration thresholds in 22 subjects with painful diabetic neuropathy who participated in a double-blind vehicle-controlled therapeutic trial" Get all the results and reference details, order at left...
5.	sorbinilIBA 04/01/1988 - "There was no significantly beneficial effect of sorbinil on clinical or neurophysiological measurements of nerve function in patients with established diabetic neuropathy" 04/01/1986 - "In a study of 11 patients with severely painful diabetic neuropathy treated with sorbinil for 3 weeks [placebo-controlled in single-blind fashion (n = 8)], pains (as assessed on a 0 to 20 rating scale) improved from a mean score of 16 down to 8, with deterioration following drug withdrawal" 11/15/1985 - "After an improvement in motor and sensory nerve conduction velocities was demonstrated in asymptomatic diabetic patients taking sorbinil (compared with velocities during a placebo period), 11 patients with painful diabetic neuropathy were treated with sorbinil for three weeks without alterations in diabetic management or control" 06/01/1985 - "It is concluded that sorbinil treatment results in some improvement in peripheral nerve function in symptomatic diabetic polyneuropathy, but that the long-term effect may be of limited value." 09/01/1988 - "In a double-blind placebo-controlled trial the effect of Sorbinil (250 mg daily) on diabetic neuropathy was examined" Get all the results and reference details, order at left...
6.	Insulin (Novolin)FDA Link 12/01/2006 - "Intensified insulin therapy plus antineuritic medication is more effective than antineuritics alone in painful diabetic neuropathy]" 10/01/1987 - "In order to study the effects of improved metabolic control on painful diabetic polyneuropathy, 15 patients were treated with continuous subcutaneous insulin infusion over a 12 month period" 05/01/2007 - "The aim of this study was to evaluate the in vivo behavioral effect of low-dose insulin on diabetic neuropathy in rats through behavioral testing in hyperglycemic conditions" 06/30/1999 - "The Diabetes Control and Complications Trial (DCCT) established the importance of hyperglyemia and other consequences of insulin deficiency in the pathogenesis of diabetic neuropathy, but the precise mechanisms by which metabolic alterations produce peripheral nerve fiber damage and loss remain unclear" 11/01/1998 - "OBJECTIVES: To study the occurrence of diabetic neuropathy and the effect of insulin treatment in elderly Type 2 diabetic patients" Get all the results and reference details, order at left...
7.	Streptozocin (Streptozotocin)FDA Link 07/15/1990 - "Both drugs were effective for the treatment of diabetic neuropathy characterized by decreased motor nerve conduction velocity, that is, slowing of tail and sciatic-tibial motor nerve conduction velocities in streptozocin-induced diabetic rats was prevented during 3 weeks by intubating Di-Cl-PSH or beta-NSH at 50 mg/kg/day" 08/01/1995 - "RESEARCH DESIGN AND METHODS--We used the model of streptozotocin-induced diabetic neuropathy (SDN) and evaluated the efficacy of LA supplementation in improving nerve blood flow (NBF), electrophysiology, and indexes of oxidative stress in peripheral nerves affected by SDN, at 1 month after onset of diabetes and in age-matched control rats" 01/01/2007 - "ABSTRACT: BACKGROUND: To study the effects of a pre-germinated brown rice diet (PR) on diabetic neuropathy in streptozotocin (STZ)-induced diabetic rats" 07/17/2006 - "In the present study, we have investigated the effect of U83836E [(-)-2-((4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,3,7,8-tetramethyl-2H-1-benzopyran-6-ol, 2HCl], a potent free radical scavenger in streptozotocin (STZ)-induced diabetic neuropathy in rats" 05/01/2006 - "Since we introduced cultured dorsal root ganglia (DRG) neurons from streptozotocin (STZ)-induced diabetic mice as "an in vitro model to study diabetic neuropathy" (Sotelo et al., 1991), more than 30 papers have been devoted to the study of diabetic neuropathy with culture systems of neurons and Schwann cells derived from adult animals" Get all the results and reference details, order at left...
8.	Nerve Growth Factor (NGF)IBA 11/01/1994 - "These findings indicate that, while NGFR expression is normal in the STZ-diabetic neuropathy model, the marked decrease in receptor saturation observed in diabetics may reflect low peripheral NGF levels, which in consequence leads to the apparent deprivation of neuronal NGF in diabetic rats." 07/01/2002 - "These results suggest that gene transfer with an NGF-producing herpes-based vector may prove useful in the treatment of diabetic neuropathy." 11/01/1996 - "One study of NGF in patients with diabetic neuropathy found that the drug improved neurologic function and produced an increase in the patients' ability to sense cooling or painful heat" 02/01/2003 - "However, a phase 3 trial in diabetic neuropathy and a phase 2 trial in HIV-related neuropathy have failed to demonstrate any substantial effect of treatment with NGF" 01/01/2001 - "Recent studies have demonstrated that deficient NGF support of peptidergic nociceptors is involved in problems with small-fiber diabetic neuropathy" Get all the results and reference details, order at left...
9.	ONO 2235 (epalrestat)IBA 05/01/1996 - "Although data are limited, they strongly suggest that epalrestat is a highly effective and safe agent for the treatment of diabetic neuropathy." 11/01/1993 - "Epalrestat 150 mg/day for 12 weeks improved motor and sensory nerve conduction velocity, and vibration threshold compared with baseline and placebo in patients with diabetic neuropathy" 05/01/1996 - "More than 5000 patients with diabetic neuropathy who were treated with epalrestat for 3-12 months were treated to analyze the efficacy and the adverse reactions of the drug in this study" 05/01/2008 - "Epalrestat may serve as a new therapeutic option to prevent or slow the progression of diabetic neuropathy" 05/01/2008 - "Unlike the current treatment options for diabetic neuropathy, epalrestat may affect or delay progression of the underlying disease process" Get all the results and reference details, order at left...
10.	Glucose (Dextrose)FDA LinkGeneric 04/01/2004 - "In the current study, we have determined that the GCP II inhibitor 2-(phosphonomethyl) pentanedioic acid (2-PMPA) is protective against glucose-induced programmed cell death (PCD) and neurite degeneration in dorsal root ganglion (DRG) neurons in a cell culture model of diabetic neuropathy" 02/01/2004 - "Racemic LA (rac-LA) has shown promise in treating diabetic polyneuropathy, and some studies suggest that it improves glucose homeostasis in patients with type 2 diabetes" 07/01/2007 - "Therefore in the present study, glucose-induced toxicity was studied in PC12 cells as an in vitro cellular model for diabetic neuropathy using the MTT assay" 12/07/2001 - "Recent studies have reported that rat sympathetic neurons exposed to increased concentrations of glucose in vitro initiate an apoptotic program which culminates in neuronal cell death, a process proposed to contribute to the development of human diabetic autonomic neuropathy" 07/01/1986 - "These results indicated the need for further long-term studies of the role of strict glucose control in the prevention of diabetic neuropathy." Get all the results and reference details, order at left...
648 Drugs and Important Bio-Agents and 1590 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Decompression 02/01/2008 - "We concluded that peripheral nerve decompression can be used effectively in the treatment of diabetic neuropathy patients." 06/01/2003 - "Finally, an electron microscopic study revealed variable degenerative changes in all groups, but they were milder in groups II and III. This experimental study reveals that adding internal decompression to external release doubled the effect in reducing derangement in the sciatic nerves of the rats and, in the authors' opinion, offers cause for further optimism in the treatment of diabetic neuropathy." 02/01/2008 - "We researched the effect of nerve decompression procedures on diabetic neuropathy cases just in the following day after surgery as well as later, at 6 months" 02/01/2008 - "Early and late results of nerve decompression procedures in diabetic neuropathy: a series from Turkiye." 07/01/2007 - "We evaluated the effects of "prophylactic" decompression procedures on the progression of diabetic neuropathy in an experimental model" Get all the results and reference details, order at left...
2.	Transcutaneous Electric Nerve Stimulation (TENS) 06/01/2004 - "In conclusion, our study indicates that the new TENS device "Salutaris" is a convenient, non-pharmacological option for primary or adjuvant treatment of painful diabetic neuropathy." 06/01/2004 - "In a double blind, randomised study, 19 patients suffering from mild-to-moderate symptomatic diabetic neuropathy (Total Symptom Score, NTSS 4-16) received either treatment with the new transcutaneous electrical nerve stimulation (TENS) device "Salutaris" (verum group) or a placebo treatment with an identical but electrically inactive device (placebo group)" 06/01/2004 - "Impact of low frequency transcutaneous electrical nerve stimulation on symptomatic diabetic neuropathy using the new Salutaris device." 08/01/1999 - "Application of TENS to the skin of the lumbar area may be an effective treatment for the pain of diabetic neuropathy." 08/01/1999 - "The purpose of this case report is to describe the alteration of pain in a patient with severe, painful diabetic neuropathy following application of transcutaneous electrical nerve stimulation (TENS) to the low back" Get all the results and reference details, order at left...
3.	Renal Dialysis (Hemodialysis) 09/01/2007 - "MATERIALS AND METHODS: All patients with diabetic neuropathy (DN) in predialysis, hemodialysis, or peritoneal dialysis (PD) in our transplantation referral area (population, 1.8 million; data collection ended December 7, 2005) were examined for basic SPK criteria (NTO 2005 Consensus)" 03/01/2002 - "BACKGROUND: Carpal tunnel syndrome (CTS) is one of the major problems of long-term hemodialysis (HD), but sometimes difficult to distinguish from uremic or diabetic neuropathy by clinical symptoms" 08/01/1989 - "There may be uremic and/or diabetic neuropathy in these patients, and these neuropathies may be responsible for the more rapid deterioration and poorer surgical results in carpal tunnel syndrome associated with hemodialysis than in idiopathic cases" 05/13/2005 - "The following items were evaluated as documented: diagnosis, type, and duration of diabetes mellitus; diabetic neuropathy and retinopathy; amputations; causes of hemodialysis" 08/21/2002 - "Venlafaxine in the treatment of painful peripheral diabetic neuropathy in a uremic patient undergoing hemodialysis." Get all the results and reference details, order at left...
4.	Analgesia 11/01/1952 - "Caudal analgesia; clinical applications in vasospastic diseases of the legs and in diabetic neuropathy." 11/01/2006 - "METHODS: We retrospectively investigated 567 patients with a preexisting peripheral sensorimotor neuropathy or diabetic polyneuropathy who subsequently underwent neuraxial anesthesia or analgesia" 11/01/2006 - "Neurologic complications after neuraxial anesthesia or analgesia in patients with preexisting peripheral sensorimotor neuropathy or diabetic polyneuropathy." 05/01/2003 - "Several AEDs have reportedly produced analgesia in a range of neuropathic pains, including painful diabetic neuropathy (PDN) and post-herpetic neuralgia" 11/01/2006 - "CONCLUSIONS: The risk of severe postoperative neurologic dysfunction in patients with peripheral sensorimotor neuropathy or diabetic polyneuropathy undergoing neuraxial anesthesia or analgesia was found to be 0.4% (95% CI 0.1%-1.3%)" Get all the results and reference details, order at left...
5.	Transplantation (Transplant Recipients) 06/01/2005 - "These findings suggest that transplantation of EPCs from cord blood may be a useful treatment for diabetic neuropathy." 11/01/2008 - "Transplantation of bone marrow-derived mesenchymal stem cells improves diabetic polyneuropathy in rats." 07/01/1998 - "Benefit of pancreatic transplantation on diabetic neuropathy: euglycemia or immunosuppression?" 11/01/1997 - "Long-term effects of pancreatic transplantation on diabetic neuropathy." 06/01/1994 - "Our data suggest that diabetic muscle pathology could be reversed and the progression of diabetic amyotrophy halted through the restoration of a euglycemic state by successful pancreatic islet transplantation, at least in short-term experimental diabetes." Get all the results and reference details, order at left...
57 Therapies and Procedures and 224 more articles analyzed in the Full Patient-Physician Summary Report, order at left...