Type 2 Diabetes Mellitus (MODY)

11515  relevant articles (625 outcomes, 2092 trials/studies) found for this Disease

MODY; Diabetes Mellitus, Type II; NIDDM; Diabetes Mellitus, Type 2; Diabetes Mellitus, Non Insulin Dependent; Diabetes Mellitus, Noninsulin Dependent; Adult-Onset Diabetes Mellitus; Diabetes Mellitus, Adult Onset; Diabetes Mellitus, Ketosis Resistant; Diabetes Mellitus, Maturity Onset; Diabetes Mellitus, Slow Onset; Ketosis-Resistant Diabetes Mellitus; Maturity Onset Diabetes Mellitus; Non-Insulin-Dependent Diabetes Mellitus; Slow-Onset Diabetes Mellitus; Stable Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Maturity-Onset; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Maturity-Onset Diabetes Mellitus

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY)
2.	Insulin Resistance
3.	Obesity
4.	Type 1 Diabetes Mellitus (Autoimmune Diabetes)
5.	Hyperglycemia
422 Diseases and 5948 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Heine, R J: 9 articles (07/2008 - 03/2000)
2.	Derosa, Giuseppe: 9 articles (03/2008 - 02/2003)
3.	Lübben, Georg: 9 articles (06/2007 - 01/2003)
4.	Chiasson, Jean-Louis: 9 articles (05/2007 - 06/2002)
5.	Lee, H K: 8 articles (08/2008 - 05/2000)
6.	Laakso, Markku: 8 articles (03/2008 - 06/2002)
7.	Bogardus, C: 8 articles (05/2007 - 01/2000)
8.	Cho, Y M: 7 articles (08/2008 - 05/2005)
9.	Park, K S: 7 articles (08/2008 - 05/2005)
10.	Hayden, Melvin R: 7 articles (07/2007 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Type 2 Diabetes Mellitus:

1.	Insulin (Novolin)FDA Link 06/01/1990 - "Most non-insulin-dependent diabetic (NIDDM) patients are also unlikely to have meaningful improvement in glycemic regulation on insulin-sulfonylurea therapy" 03/01/1998 - "To date, insulin is the only hypoglycaemic agent which has been proven both effective and safe in NIDDM patients with cardiovascular complications" 06/01/2008 - "WS treatment significantly improved insulin sensitivity index (K(ITT)) that was significantly decreased in NIDDM control rats" 12/01/1995 - "Insulin (500 mU/ml) added acutely during the fluorescence reading caused a rapid 31 +/- 3.9 percent rise in intracellular Mg(2+) in the normal subjects, which was significantly greater than the 18 +/- 1.6 percent rise observed in the NIDDM subjects (P < 0.01)" 11/01/1988 - "Control of diabetes with short term therapy (2-6 weeks) resulted in a significant improvement in the mean specific insulin binding in both FCPD and NIDDM patients (P less than 0.001) due to increased binding affinity in the former, and increased affinity and the number of binding sites in the latter" Get all the results and reference details, order at left...
2.	Glucose (Dextrose)FDA LinkGeneric 09/01/2004 - "Although there is widespread use of herbal dietary supplements that are believed to benefit type 2 diabetes mellitus, few have been proven to do so in properly designed randomized trials; their efficacy for intermediate-term glucose control remains unclear" 12/01/2005 - "BACKGROUND: Although both strength training (ST) and endurance training (ET) seem to be beneficial in type 2 diabetes mellitus (T2D), little is known about post-exercise glucose profiles" 06/01/1996 - "Impaired glucose tolerance (IGT) male subjects showed significantly greater thickness of the intimal plus medial complex (IMT) than age-matched healthy males and showed no significant differences compared to age-matched NIDDM patients" 02/21/1987 - "In contrast, the patients with non-insulin-dependent diabetes mellitus showed a significant improvement in their glucose tolerance, which paralleled the severity of their diabetes" 01/01/1987 - "These sources were found to be potentially beneficial in the reduction of plasma glucose in non-insulin dependent diabetes mellitus subjects" Get all the results and reference details, order at left...
3.	Metformin (Glucophage)FDA LinkGeneric 12/01/2008 - "Metformin is widely used for the treatment of type 2 diabetes mellitus" 08/01/2007 - "Both slow-release (SR) and regular-release (RR) metformin were effective in the treatment of type 2 diabetes mellitus" 12/01/2005 - "BACKGROUND: Metformin hydrochloride is widely used for the treatment of type 2 diabetes mellitus (DM-2)" 01/01/2005 - "BACKGROUND AND OBJECTIVE: Metformin is an effective treatment for type 2 diabetes mellitus" 06/01/2003 - "BACKGROUND: Few data are available on the long-term efficacy of metformin, one of the main drugs in the treatment of type 2 diabetes mellitus" Get all the results and reference details, order at left...
4.	Blood Glucose (Blood Sugar)IBA 01/01/2000 - "A multicentric study by the Indian Council of Medical Research showed that a preparation from Pterocarpus marsupium was effective in reducing levels of blood glucose and glycosylated haemoglobin in patients with non-insulin-dependent diabetes mellitus" 05/20/2006 - "BACKGROUND AND OBJECTIVE: The efficacy of self-measurement of capillary blood glucose (SMBG) in patients with type 2 diabetes mellitus is not fully established" 04/01/2006 - "CONCLUSION: The randomized clinical trials performed to date provided positive results on the effectiveness of interventions with self-monitoring of blood glucose in type 2 diabetes mellitus" 12/12/1998 - "This multi-center, prospective, randomized, intervention trial of 5102 newly-diagnosed patients with type 2 diabetes mellitus was aimed at determining whether improved blood glucose control can prevent complications and reduce associated morbidity and mortality" 09/01/1997 - "OBJECTIVE: To determine the efficacy of self-monitoring of blood glucose (SMBG) in NIDDM patients from studies published during the years 1976-1996" Get all the results and reference details, order at left...
5.	AcarboseFDA Link 09/01/2005 - "The STOP-NIDDM trial confirmed the efficacy of acarbose in decreasing the risk of diabetes by 36% in similar high risk population" 01/01/2006 - "CONCLUSION: The STOP-NIDDM Trial demonstrated that, in subjects with IGT, acarbose treatment was effective in reducing the risk of type 2 diabetes" 02/16/1997 - "Acarbose was shown to be effective in treating NIDDM and to be safe and well-tolerated." 03/01/1989 - "These findings demonstrate that acarbose is effective in moderating the metabolic effects of NIDDM in this diabetic rodent model, and suggest that acarbose may have potential in the management of NIDDM in humans." 02/01/1996 - "These results indicate that treatment with acarbose is safe and effective in adjunct to dietary therapy for the treatment of NIDDM." Get all the results and reference details, order at left...
6.	Glyburide (Glibenclamide)FDA LinkGeneric 01/01/2002 - "CONCLUSIONS: Compared with glyburide, Mix75/25 significantly improved glycemic control in older patients with type 2 diabetes mellitus, could be administered after meals without compromising glycemic control, and was well tolerated." 04/01/1998 - "Oral first-line treatment of type 2 diabetes mellitus is usually initiated with glibenclamide (glyburide), which is known to increase bodyweight (reflecting group B)" 03/01/1998 - "In this study nine patients with Type 2 diabetes mellitus were subjected to four treatments in random order on separate days: (A) endurance exercise after the administration of 3.5 mg glibenclamide; (B) as A but given only 1.75 mg glibenclamide; (C) as A but with placebo; (D) rest and administration of 1.75 mg glibenclamide" 01/01/1997 - "Clinical study of glibenclamide in combination with kelening treatment in non-insulin dependent diabetes mellitus]" 10/01/1994 - "In a placebo-controlled, double-blind crossover trial, 32 patients with NIDDM with suboptimal control on chronic glyburide treatment fulfilling entry criteria were randomized to receive one of two regimens: (1) glyburide at bedtime and placebo in morning or (2) placebo at bedtime and glyburide in the morning" Get all the results and reference details, order at left...
7.	rosiglitazone (Avandia)FDA Link 01/01/2005 - "Predictive clinical parameters for therapeutic efficacy of rosiglitazone in Korean type 2 diabetes mellitus." 10/01/2007 - "The objective of this study was to determine if rosiglitazone (RSG) reduced the odds of restenosis and if RSG improved the odds of clinical outcomes after percutaneous coronary intervention (PCI) in type 2 diabetes mellitus (DM) patients" 09/01/2003 - "OBJECTIVE: To assess the clinical safety and efficacy of rosiglitazone maleate in the treatment of patients with type 2 diabetes mellitus" 09/01/2003 - "The safety and efficacy of rosiglitazone maleate in the treatment of patients with type 2 diabetes mellitus in China]" 01/01/2007 - "Published studies of at least 24 weeks rosiglitazone treatment in people with type 2 diabetes mellitus did not provide evidence that patient-oriented outcomes like mortality, morbidity, adverse effects, costs and health-related quality of life are positively influenced by this compound" Get all the results and reference details, order at left...
8.	pioglitazone (Actos)FDA Link 09/01/2000 - "These data suggest pioglitazone to be effective in reducing UAE and urinary ET-1 concentrations in NIDDM patients with microalbuminuria." 10/01/2007 - "BACKGROUND: The aim of this study is to explore appropriate indicators for the efficacy of pioglitazone (Pio) before and during treatment of Japanese patients with type 2 diabetes mellitus (T2DM)" 03/01/2006 - "Pioglitazone, another TZD, marginally decreased the incidence of cardiovascular complications in patients with Type 2 diabetes mellitus (PROactive trial)" 06/01/2006 - "Safety and efficacy of low-dose pioglitazone (7.5 mg/day) vs. standard-dose pioglitazone (15 mg/day) in Japanese women with type 2 diabetes mellitus." 09/12/2007 - "Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials." Get all the results and reference details, order at left...
9.	troglitazone (Rezulin)FDA Link 09/01/2001 - "Troglitazone is effective in approximately 50% in patients with type 2 diabetes (NIDDM)" 08/01/1998 - "In order to assess the relationship between clinical efficacy of troglitazone on glycemic control and baseline characteristics of patients with NIDDM, we analyzed the data of ten clinical studies on troglitazone carried out in Japan" 02/01/1996 - "OBJECTIVE: To investigate the clinical efficacy of troglitazone, a newly developed oral hypoglycemic agent, in patients with NIDDM" 05/01/2003 - "A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus." 02/01/2001 - "STUDY OBJECTIVE: To characterize frequency of liver enzyme elevation in patients with type 2 diabetes mellitus receiving troglitazone" Get all the results and reference details, order at left...
10.	Glipizide (Glucotrol)FDA LinkGeneric 09/01/2000 - "Quality of life was improved compared with baseline after 12 weeks' treatment with glipizide GITS 5 to 20 mg/day plus diet in a US double-blind, placebo-controlled trial in 569 patients with type 2 diabetes mellitus" 12/01/1994 - "Comparative efficacy of a once-daily controlled-release formulation of glipizide and immediate-release glipizide in patients with NIDDM." 09/01/2006 - "OBJECTIVE: The aim of this study was to compare the efficacy and tolerability of a sustained-release glipizide (GSR) formulation with those of immediate-release glipizide (GIR) in Chinese patients with type 2 diabetes mellitus" 09/01/2006 - "Sustained-release versus immediate-release glipizide for treatment of type 2 diabetes mellitus in chinese patients: A randomized, double-blind, double-dummy, parallel-group, 12-week clinical study." 08/01/1990 - "In the second study, the diurnal glycemic excursions in 8 NIDDM patients chronically and continuously (24 h/day) exposed to glipizide (2.5-7.5 mg 3 times/day) were similar when the drug was taken 30 min before each of the three main meals and when taken immediately before the meals" Get all the results and reference details, order at left...
1768 Drugs and Important Bio-Agents and 11232 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Exercise (Aerobic Exercise) 11/01/1995 - "This study shows that improvement in physical fitness by introducing regular physical exercise as part of the treatment programme in patients with NIDDM results in a significant amelioration of their cardiovascular risk profile." 12/01/1994 - "CONCLUSIONS--Lifestyle modification consisting of diet combined with aerobic exercise can be effective for controlling NIDDM and reducing risk factors associated with macrovascular complications in both men and women" 02/01/2008 - "In conclusion, aerobic exercise training improved glycemic control and reduced oxidative stress in patients with type 2 diabetes mellitus" 02/01/2007 - "During the past 50 years several studies have underlined the central role of physical exercise in the management of patients with both type 1 and type 2 diabetes mellitus" 11/01/2008 - "SUBJECTS AND METHODS: Fifteen participants with type 2 diabetes mellitus (T2DM) participated in a 16-week supervised exercise training program: 7 (mean age=50.7 years, SD=6.9) in a combined aerobic and eccentric resistance exercise program (AE/RE group) and 8 (mean age=58.5 years, SD=6.2) in a program of aerobic exercise only (AE group)" Get all the results and reference details, order at left...
2.	Diet Therapy (Therapy, Diet) 01/01/1981 - "The efficacy of diet therapy used for one patient with the newly classified maturity-onset diabetes of the young (MODY) is reported" 01/01/2007 - "The aim of the study to assess the efficacy diet therapy recommended for patients who were recently found to have type 2 diabetes mellitus as well as the influence of the diet on metabolic control of the subjects" 10/01/2004 - "The aim of this study was to determine the effect of diet-therapy on lipid peroxidation in patients with Type 2 diabetes mellitus (T2DM)" 08/01/1991 - "A study was undertaken to find out how the hedonic responses to, and reported liking and consumption of, sweet and fat foods change during the first months of diet therapy of recently diagnosed patients with non-insulin-dependent diabetes mellitus" 07/01/2002 - "Diet therapy is an essential instrument in the prevention and treatment of non-insulin-dependent diabetes mellitus and its complications" Get all the results and reference details, order at left...
3.	Drug Therapy (Chemotherapy) 11/01/2006 - "PURPOSE: The objectives of the present study were (1) to discern trends in the prescribing of oral pharmacotherapy for the management of type 2 diabetes mellitus (DM) in the United States during the years 1990 through 2001 and (2) to examine the mediating role of primary health insurance coverage on patients' access to pharmaceutical innovation for the management of type 2 DM" 06/01/2005 - "STUDY OBJECTIVES: To assess the characteristics of children with type 2 diabetes mellitus and to determine the efficacy and safety of drug therapies for this disease in this population" 06/01/1999 - "To obtain such insight, we used 10 years of electronic medical-record data from Kaiser Permanente Northwest Division, a large, group-model health maintenance organization in the United States, to study drug transitions, lapses in drug therapy, and mortality among 693 persons with newly diagnosed type 2 diabetes mellitus in 1988" 01/01/1998 - "The United Kingdom Prospective Diabetes Study (UKPDS) implications for the pharmacotherapy of type 2 diabetes mellitus." 01/19/2008 - "Drug therapy is less effective than lifestyle modifications in the prevention of type 2 diabetes mellitus" Get all the results and reference details, order at left...
4.	Caloric Restriction 09/16/2008 - "OBJECTIVES: This study sought to assess the effects of prolonged caloric restriction in obese patients with type 2 diabetes mellitus (T2DM) on myocardial triglyceride (TG) content and myocardial function" 09/16/2008 - "Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function." 01/01/2002 - "Influence of caloric restriction diet on clinical and biochemical parameters in patients with type 2 diabetes mellitus]" 05/01/1995 - "Research is needed to explore new ways to use VLCDs and other approaches to caloric restriction in the treatment of obese persons with NIDDM." 02/01/1995 - "Is caloric restriction effective in preventing diabetes mellitus in the Otsuka Long Evans Tokushima fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus?" Get all the results and reference details, order at left...
5.	Aftercare (After-Treatment) 04/01/1994 - "Lipid composition of platelets in patients with non-insulin-dependent diabetes mellitus: studies before and after treatment of diabetes." 02/01/1992 - "Acid cholesteryl ester hydrolase activity of mononuclear leukocytes in patients with non-insulin-dependent diabetes mellitus: studies before and after treatment of diabetes." 06/20/2008 - "Biochemical and genetic data support the notion that IDE may play a role in late onset Alzheimer disease (AD), and recent studies suggest an association between AD and diabetes mellitus type 2. Here we show that a natively folded recombinant IDE was capable of forming a stable complex with Abeta that resisted dissociation after treatment with strong denaturants" 03/01/2001 - "Further, an increase of insulin resistance and development of non-insulin-dependent diabetes mellitus has been described after treatment with IFN-alpha" 04/01/1999 - "Five patients (33.3%) three with IDDM and two with NIDDM developed DON with 50% improvement of visual acuity after treatment, whereas in the whole population of 482 GO patients 19 had DON (3.9%), showing 69.4% improvement of vision after treatment" Get all the results and reference details, order at left...
139 Therapies and Procedures and 598 more articles analyzed in the Full Patient-Physician Summary Report, order at left...