Experimental Diabetes Mellitus

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1540 relevant articles (31 outcomes, 125 trials/studies) found for this Disease

Description: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.

Also Known As:

Diabetes Mellitus, Experimental; Diabete, Streptozocin; Diabetes, Alloxan; Diabetes, Streptozocin; Diabetes, Streptozotocin; Streptozocin Diabete; Alloxan Diabetes; Streptozocin Diabetes; Streptozotocin Diabetes

Relationship Network

Disease Context: Research Results

Nutritional and Metabolic Diseases

Metabolic Diseases: 1264

Glucose Metabolism Disorders: 39

Diabetes Mellitus: 22586

Experimental Diabetes Mellitus: 1540

Endocrine System Diseases: 390

Diabetes Mellitus: 22586

Experimental Diabetes Mellitus: 1540

Related Diseases

1.	Body Weight (Weight, Body)
2.	Inflammation
3.	Poisoning
4.	Cardiomyopathies (Cardiomyopathy)
5.	Diabetes Mellitus
103 Diseases and 240 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Prysiazhna, O D: 5 articles (01/2008 - 01/2003)
2.	Sahach, V F: 4 articles (01/2008 - 01/2003)
3.	Kotsiuruba, A V: 4 articles (01/2007 - 01/2003)
4.	Tkachenko, M M: 3 articles (01/2007 - 01/2003)
5.	Patel, Samir P: 3 articles (09/2006 - 01/2006)
6.	Katyare, Surendra S: 3 articles (09/2006 - 01/2006)
7.	Brodiak, I V: 2 articles (01/2008 - 09/2006)
8.	Sybirna, N O: 2 articles (01/2008 - 09/2006)
9.	Bilichenko, S V: 2 articles (05/2007 - 01/2006)
10.	Lebedev, V P: 2 articles (05/2007 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Experimental Diabetes Mellitus:

1.	Insulin (Novolin)FDA Link 02/01/1983 - "Induction of streptozotocin-diabetes in rats weighing 200 g resulted in a marked decrease in the insulin responsiveness of fat cells" 01/01/2005 - "Effects of streptozotocin-diabetes and insulin replacement on the epididymis of prepubertal rats: histological and histomorphometric studies." 07/01/1999 - "To ascertain the glomerular hemodynamic basis for this effect of ACEI, micropuncture studies were performed in male Wistar-Froemter rats after 5 to 6 wk of insulin-treated streptozotocin diabetes" 07/01/1997 - "In the present study we examined the converse condition by testing the effects of chronic salt loading on kidney function in moderately hyperglycemic insulin-treated rats with early and established streptozotocin diabetes" 09/01/1996 - "The present study sought to determine the effect of short-term (one month) and acute (one hour) insulin reversal treatment on nerve blood flow deficits in streptozotocin-diabetes" Get all the results and reference details, order at left...
2.	Glucose (Dextrose)FDA LinkGeneric 11/01/1981 - "The present study suggests that although streptozotocin diabetes alters plasma-ocular glucose transport, there is no direct impairment of glucose carrier function" 07/01/2003 - "Brown adipose tissue (BAT) glyceroneogenesis was evaluated in rats either fasted for 48 h or with streptozotocin-diabetes induced 3 days previously or adapted for 20 days to a high-protein, carbohydrate-free (HP) diet, conditions in which BAT glucose utilization is reduced" 07/01/1997 - "Maternal semistarvation and streptozotocin-diabetes in rats have different effects on the in vivo glucose uptake by peripheral tissues in their female adult offspring." 11/01/1995 - "Level of glucose in blood, gas exchange, and hematologic indicators of rats with experimental diabetes mellitus after carotid glomectomy]" 10/01/1993 - "Using 13C-NMR spectroscopy, we investigated the effects of experimentally induced diabetes (streptozotocin 65 mg/kg, i.v.) on glucose metabolism and contractile function in the isolated perfused rat heart" Get all the results and reference details, order at left...
3.	AlloxanIBA 01/01/1995 - "Protection against alloxan diabetes by low-dose 60Co gamma irradiation before alloxan administration." 05/01/1980 - "In starved mice injected with MH before alloxan there was an inhibition of the initial hyperglycaemia, but occurrence of a "second" hyperglycaemia, suggesting an absence of protection against the development of alloxan diabetes" 04/01/2002 - "DTZ, 20 mg/kg, was orally administered to control rabbits and rabbits with fifth day (experiment was performed at fifth day after first and second days intravenous administration of alloxan) and 13th day (experiment was performed at 13th day after first, second, sixth, and 10th days intravenous administration of alloxan) diabetes mellitus induced by alloxan" 07/01/1993 - "Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique." 05/01/1992 - "A new model of experimental diabetes mellitus in dogs (a combination of pancreas resection with intraarterial administration of alloxan) was recommended." Get all the results and reference details, order at left...
4.	Blood Glucose (Blood Sugar)IBA 01/01/2006 - "Transcranial stimulation normalizes blood sugar levels in alloxan diabetes in rats." 05/01/1980 - "The data show that alloxan diabetes may develop in the absence of an "initial" hyperglycaemia and a triphase blood glucose response" 03/01/1956 - "Alloxan diabetes in the hamster: dosage and blood sugar curves." 02/01/2007 - "Exposure of rats with experimental diabetes mellitus to wide-band electromagnetic radiation generated by He-Ne laser and modulated by the pancreas and spleen is informing and phenomenological method prolonging animal life span, normalizing blood glucose level, and promoting regeneration of the pancreas." 03/01/1978 - "A microelectrode intracellular leading off of the postsynaptic potentials of isolated skeletal muscles was carried out in rats with alloxan diabetes of short duration (1--5 weeks), but manifest (blood sugar level from 150 to 350 mg%)" Get all the results and reference details, order at left...
5.	DNA (Deoxyribonucleic Acid)IBA 01/01/1994 - "Comparative analysis of serum DNA content in healthy rats, rats with experimental alloxan diabetes, and the rats with the diabetes compensated by transplantation of the embryonal pancreas into the anterior chamber of the eye" 12/01/2000 - "Alkylation of DNA leads to necrosis of pancreatic beta cells and thus to a state of insulin-dependent diabetes mellitus, well-known as streptozotocin diabetes in experimental diabetes research." 05/05/2000 - "Comparison of therapeutic regimens in the amelioration of alterations in rat gastrointestinal mucosal DNA, RNA and protein induced by streptozotocin diabetes mellitus." 12/01/1976 - "1. Kidney weight and content of protein, RNA and DNA were measured in rats with streptozotocin diabetes of varying duration" 01/01/1971 - "Effect of insulin on DNA synthesis and DNA polymerase activity in organ culture of rat mammary carcinoma, and the inflence of insulin pretreatment and of alloxan diabetes." Get all the results and reference details, order at left...
6.	Streptozocin (Streptozotocin)FDA Link 11/01/1996 - "The purpose of this study was to examine the mechanisms of alterations in cardiac K+ channel function in early stages of experimental diabetes mellitus induced by streptozotocin" 04/01/1995 - "The present studies examined the effects of streptozotocin induced diabetes on the concentrations of CA-III. The concentration of CA-III in the liver, muscles and serum of rats with experimental diabetes mellitus was measured by the method of enzyme-immunoassay" 02/01/1992 - "This study examined the effect of experimental diabetes mellitus on the dorsal tongue of rats which were made diabetic by tail-vein injections of streptozotocin (50 mg/kg) and then raised for either 5 or 10 months" 05/01/2007 - "METHODS: We used two distinct animal models of chemical diabetes (alloxan-induced in the rabbit and streptozotocin-induced in the rat) with or not T supplementation" 08/01/2006 - "Streptozotocin is well known inducer of experimental diabetes mellitus when injected peripherally" Get all the results and reference details, order at left...
7.	Galactose (Galactopyranose)FDA LinkGeneric 01/26/1953 - "A biochemical aspect of the crystalline lens of the rat during a diet rich in galactose and in alloxan diabetes.]" 11/09/1998 - "Nerve conduction velocity, laser Doppler flow, and axonal caliber in galactose and streptozotocin diabetes." 03/20/1992 - "CNTF-like activity, found in nerve extracts by in vitro bioassay, was reduced to 20% of control values after 1 or 2 months of galactose feeding (both P less than 0.01) and to 70% of control values after two months of streptozotocin diabetes (P less than 0.01)" 11/01/1981 - "The purpose of this study was to compare endoneurial fluid pressure (EFP) in the peripheral nerves of rats in three experimental models: streptozotocin diabetes, galactose neuropathy, and sucrose intoxication" 03/26/1999 - "Neither streptozotocin diabetes nor galactose intoxication affected the amount of 125I-labeled BDNF retrogradely transported to the DRG after injection into the sciatic nerve" Get all the results and reference details, order at left...
8.	FructoseIBA 09/01/1974 - "Effect of fructose administration on liver glycolysis in rate with alloxan diabetes]" 03/24/1972 - "Increased fructose production by the brain in alloxan diabetes." 02/27/1953 - "Protection against alloxan diabetes by mannose and fructose." 01/01/1961 - "Inclusion of methionine-S35 into liver slices of rats with alloxan diabetes in a medium containing glucose or fructose.]" 03/01/1958 - "Studies on the comparative utilization of glucose, fructose and galactose in alloxan-diabetes." Get all the results and reference details, order at left...
9.	HexokinaseIBA 07/01/1970 - "Hexokinase activity of cardiac muscle in animals with alloxan diabetes]" 09/01/1967 - "A study of the effect of alloxan-diabetes on mammary-gland hexokinase during the mid-lactation period revealed that, although the total glucose-phosphorylating capacity of the mammary gland was almost unchanged, the relative contributions of type I and type II hexokinases altered, decreasing the type II/type I activity ratio to about 1." 10/01/1968 - "The effect of anti-insulin serum and alloxan-diabetes on the distribution and multiple forms of hexokinase in lactating rat mammary gland." 03/01/1984 - "The present paper is concerned with the effects of the above-indicated compounds on the activity of glycogen phosphorylase (a- and b-forms), phosphoprotein phosphatase and hexokinase in liver and muscle tissues of white rats with alloxan diabetes" 07/01/1971 - "Activity of hexokinase and glucose-6-phosphate dehydrogenase in hemopoietic cells of the bone marrow in normal rabbits and after hydrocortisone administration during starvation and alloxan diabetes]" Get all the results and reference details, order at left...
10.	Messenger RNA (mRNA)IBA 02/27/2001 - "These results indicate that GLUTx1 mRNA and protein have a unique expression pattern in rat hippocampus and suggest that streptozotocin diabetes increases steady-state mRNA levels in the absence of concomitant increases in GLUTx1 protein expression." 01/01/1997 - "Renal antioxidant enzyme mRNA levels are increased in rats with experimental diabetes mellitus." 07/01/1995 - "After 19-d maternal insulinopenic diabetes (streptozotocin), placental GLUT3 mRNA and protein levels were increased four-to-fivefold compared to nondiabetic rats, whereas GLUT1 mRNA and protein levels remained unmodified" 01/01/1995 - "In case of Zucker rats we did not detect any significant change in grp78 mRNA, grp78 protein level showed opposite changes being essentially unchanged in streptozotocin-diabetes and significantly reduced in Zucker rats" 03/01/1993 - "Effect of streptozotocin-diabetes on the level of VIP mRNA in myenteric neurones." Get all the results and reference details, order at left...
820 Drugs and Important Bio-Agents and 1484 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 01/01/1991 - "Transplantation of the embryonic pancreas to an immune privileged area (the anterior chamber of the eye) ensures considerable improvement of the condition of animals with alloxan diabetes" 04/01/1982 - "Normal response to pregnancy in rats cured of streptozotocin diabetes by transplantation of one fetal pancreas." 09/01/2001 - "Study of the reversibility of endothelial dysfunction in a rat model of diabetes mellitus: experimental treatment by transplantation of pancreatic islets." 11/01/2001 - "Reversal of streptozotocin-diabetes after transplantation of piscine principal islets to nude mice." 01/01/1998 - "Pancreatic transplantation reverses endothelial dysfunction in experimental diabetes mellitus." Get all the results and reference details, order at left...
2.	Islets of Langerhans Transplantation 03/01/1981 - "To establish the neural mediation of this reflex response we used rats that were cured from streptozotocin diabetes by intrahepatic islet-transplantation as a denervated B-cell preparation" 01/01/1988 - "Preliminary report on microencapsulated islet transplantation in experimental diabetes mellitus in China." 05/01/1983 - "Hypogastrinemia in streptozotocin diabetes with islet transplantation--reconstitution." 12/01/2001 - "Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart." 10/27/2001 - "METHODS: Homologous islet transplantation was performed in inbred Lewis rats 15 days (TA), 4 months (TB), and 8 months (TC) after streptozotocin diabetes" Get all the results and reference details, order at left...
3.	Pancreas Transplantation 09/01/1975 - "Long term studies of pancreas transplantation in experimental diabetes mellitus." 07/01/1980 - "Prevention by whole pancreas transplantation of glomerular basement membrane thickening in alloxan diabetes." 01/01/1976 - "Effect of whole pancreas transplantation on eye lesions of alloxan diabetes." 03/01/1974 - "Recovery from experimental diabetes mellitus in mice after pancreas transplantation." 04/01/2000 - "In conclusion, in a rat model with streptozotocin-diabetes and pancreas transplantation but no need for immunosuppression, both systemic and portal venous drainage avoid peripheral and hepatic insulin resistance; also, there is no increased risk for atherosclerosis." Get all the results and reference details, order at left...
4.	Transplants (Transplant) 03/01/2008 - "METHODS: Sixty inbred male Lewis rats were assigned to four experimental groups: NC-15 nondiabetic control rats; DC-15 untreated diabetic control rats; PT1-15 diabetic rats that received syngeneic pancreas transplants 2 weeks after alloxan diabetes induction; PT2-15 diabetic rats that received pancreas transplants 12 weeks after diabetes onset" 03/01/1964 - "PANCREAS GRAFT IN THE ANTERIOR CHAMBER OF THE EYE OF THE RAT WITH ALLOXAN DIABETES.]" 03/01/1964 - "SUBCONJUNCTIVAL PANCREATIC GRAFT IN A RAT WITH ALLOXAN DIABETES.]" 02/01/1988 - "To compare the long-term effectiveness of whole pancreas transplantation and pancreatic islet transplantation in controlling the metabolic disorders of alloxan diabetes, metabolic studies were performed monthly for 2 years in 4 groups of highly inbred rats: (1) NC-116 nondiabetic controls; (2) DC-273 untreated alloxan-diabetic controls; (3) PDT-182 rats that received syngeneic pancreaticoduodenal transplants shortly after induction of diabetes with alloxan; and (4) IT-92 rats that received an intraportal injection of at least 1500, but usually 2000, syngeneic pancreatic islets shortly after induction of diabetes with alloxan" 09/01/1987 - "To compare the long-term effectiveness of whole pancreas transplantation and pancreatic islet transplantation in controlling the metabolic disorders and preventing the kidney lesions of alloxan diabetes, metabolic and morphologic studies were performed in four groups of rats: (1) NC-116 nondiabetic controls; (2) DC-273 untreated alloxan-diabetic controls; (3) PDT-182 rats that received syngeneic pancreaticoduodenal transplants not long after induction of diabetes with alloxan; and (4) IT-92 rats that received an intraportal injection of at least 1500 and usually 2000 syngeneic pancreatic islets soon after induction of diabetes with alloxan" Get all the results and reference details, order at left...
5.	Isogeneic Transplantation 08/01/1975 - "Serial renal morphologic, ultrastructural immunohisotlogic and functional studies were done on diabetic Lewis rats to evaluate the course of nephropathy and to study the effects of early pancreatic isografts on renal disease associated with streptozotocin diabetes" 06/15/1996 - "Syngeneic transplantation of rat islets into subcutaneous tissue failed to cure streptozocin diabetes" 11/01/1979 - "Ocular fluorophotometry in streptozotocin diabetes mellitus in the rat: effect of pancreatic islet isografts." 02/01/1979 - "Reversal of insulinopenia, hyperglycemia, glycosuria, and polyuria associated with severe alloxan diabetes in the rat was accomplished by syngeneic transplantation of whole late-gestation fetal rat pancreata" 09/01/1975 - "Alloxan diabetes was induced in inbred rats that then were divided into four groups consisting of unoperated diabetic controls, sham-operated diabetic controls, rats given pancreaticoduodenal isografts, and rats given duct-ligated pancreas isografts" Get all the results and reference details, order at left...
36 Therapies and Procedures and 119 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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Research Summary Report
on Experimental Diabetes Mellitus

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