Diabetes Insipidus

A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.

Networked: 2556 relevant articles (84 outcomes, 108 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypopituitarism (Sheehan's Syndrome)
2.	Hyponatremia
3.	Neoplasms (Cancer)
4.	Hypothyroidism
5.	Diabetes Mellitus

Experts

1.	Christ-Crain, Mirjam: 10 articles (05/2022 - 07/2007)
2.	Refardt, Julie: 8 articles (01/2022 - 12/2018)
3.	Laws, Edward R: 7 articles (06/2022 - 05/2005)
4.	Arima, Hiroshi: 7 articles (10/2020 - 05/2009)
5.	Rej, Soham: 7 articles (01/2020 - 01/2011)
6.	Thompson, Christopher J: 6 articles (06/2017 - 12/2004)
7.	Thompson, C J: 6 articles (03/2015 - 10/2002)
8.	Oiso, Yutaka: 6 articles (01/2014 - 11/2003)
9.	Bichet, Daniel G: 5 articles (01/2022 - 07/2005)
10.	Hagiwara, Daisuke: 5 articles (10/2020 - 12/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Diabetes Insipidus:

1.	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 01/01/1990 - "During nursing the diabetes insipidus improved significantly whereby DDAVP doses could be reduced to 20-10 percent. " 05/01/2009 - "Overall, growing experience with DDAVP has shown that it is a safe and effective treatment for diabetes insipidus caused by a variety of factors." 11/01/2004 - "Diabetes insipidus (DI) was observed in 10/18 patients before surgery and in 15/18 patients after surgery; during surgery it was effectively treated with synthetic desmopressin (DDAVP) and hydroelectrolytic solutions. " 02/01/1978 - "Two patients with acute postoperative diabetes insipidus were effectively treated with 5 microgram of dDAVP every 14 to 18 h. " 07/23/1977 - "A single dose of 20 micrograms of DDAVP given intranasally had an antidiuretic action from 16 to 24 hours in the three cases, and 10 micrograms given twice daily intranasally was effective in controlling the diabetes insipidus with no side effects. "
2.	Vasopressins (Vasopressin)IBA 01/01/1982 - "The use of animals with diabetes insipidus, particularly the Brattleboro homozygous (DI) rat, may help to circumvent a number of methodological problems and provide a useful model for assessing the role of vasopressin in the control of renal hemodynamics. " 01/01/2019 - "Viral rescue of magnocellular vasopressin cells in adolescent Brattleboro rats ameliorates diabetes insipidus, but not the hypoaroused phenotype." 08/01/2000 - "The naturally-occurring frame-shift mutation in the hereditary diabetes insipidus (Brattleboro) rat completely eliminated vasopressin expression. " 02/01/1983 - "She was treated with intranasal vasopressin for diabetes insipidus and responded well to treatment. " 01/01/2023 - "Vasopressin-deficient Brattleboro rats are a model of hereditary hypothalamic diabetes insipidus that have been used extensively for the study of vasopressin actions in behavior and physiology. "
3.	GlucocorticoidsIBA 01/01/2010 - "High dose glucocorticoid treatment resulted in markedly improved symptoms, and resolution of focal symptoms and diabetes insipidus. " 06/07/2023 - "The survival rate was higher in the GH group (HR [hazard ratio] 0.60; P = .01) and reduced in patients with glucocorticoid replacement (HR 2.02; P < .01) or diabetes insipidus (HR 1.67; P = .04). " 08/01/2017 - "Diabetes insipidus appears as a negative prognostic factor for response to glucocorticoids." 03/01/2008 - "In this report, we show a case of ECD presenting diabetes insipidus and multiple xanthogranulomas received glucocorticoid treatment over a year. " 04/01/1991 - "At the terminal stage, plasma AVP did not increase in response to the withdrawal of glucocorticoid and urine volume remained decreased, suggesting the presence of masked diabetes insipidus. "
4.	Hormones (Hormone)IBA 01/01/2020 - "The rate of persistent new hormone deficit was low at 8%, including a 2.8% rate of permanent diabetes insipidus, and 45% of patients had improvement in preoperative hormone deficit following surgery. " 12/16/2014 - "Four of these were cured, 10 patients developed postoperative anterior pituitary hormone deficiency, and one patient developed diabetes insipidus. " 04/01/1981 - "These studies have evaluated the relationship between renal PG synthesis and hormone levels in rats with hereditary diabetes insipidus, a species devoid of circulating ADH. " 01/01/2023 - "Pre-surgical diabetes insipidus was only seen in Group B, in which also hormone deficiencies were more frequent and numerous. " 10/28/2022 - "All patients had pituitary abnormalities on radiological assessment, 6 developed diabetes insipidus (DI), and 8 presented with anterior pituitary hormone deficiencies in the disease duration. "
5.	Hydrocortisone (Cortisol)FDA LinkGeneric 07/01/1998 - "Partial tumour remission was achieved resulting in decreased cortisol production and disappearance of the diabetes insipidus. " 10/01/2003 - "We report the results of a prospective randomized controlled trial, which looked at the incidence of postoperative diabetes insipidus (DI) following the use of three different hydrocortisone protocols, and the results of a study, on the incidence of DI and cortisol response in patients not given hydrocortisone. " 10/01/2003 - "Hydrocortisone dose and postoperative diabetes insipidus in patients undergoing transsphenoidal pituitary surgery: a prospective randomized controlled study." 06/14/2023 - "The pooled data revealed a higher incidence of postoperative transient diabetes insipidus in the no-hydrocortisone group than in the hydrocortisone group (RR, 1.88; 95% CI, 1.13 to 3.12; p = 0.02). " 11/01/2022 - "Postoperatively, the patient developed transient diabetes insipidus and hydrocortisone dependence but was neurologically intact and eupituitary on follow-up. "
6.	Arginine Vasopressin (Argipressin)IBA 12/01/1995 - "Transient diabetes insipidus in pregnancy--a consequence of enhanced placental clearance of arginine vasopressin." 11/28/2022 - "A working group of representatives from national and international endocrinology and pediatric endocrine societies now proposes changing the name of "diabetes insipidus" to "Arginine Vasopressin Deficiency (AVP-D)" for central etiologies, and "Arginine Vasopressin Resistance (AVP-R)" for nephrogenic etiologies. " 11/17/2022 - "A working group of representatives from national and international endocrinology and endocrine pediatric societies now proposes changing the name of "diabetes insipidus" to "Arginine Vasopressin Deficiency (AVP-D)" for central etiologies, and "Arginine Vasopressin Resistance (AVP-R)" for nephrogenic etiologies This editorial provides both the historical context and the rational for this proposed name change." 11/01/2022 - "A working group of representatives from national and international endocrinology, nephrology and pediatric societies now proposes changing the name of 'diabetes insipidus' to 'arginine vasopressin deficiency (AVP-D)' for central etiologies and 'arginine vasopressin resistance (AVP-R)' for nephrogenic etiologies. " 11/01/2022 - "A working group of representatives from national and international endocrinology, and pediatric endocrine societies now proposes changing the name of 'diabetes insipidus' to 'arginine vasopressin deficiency (AVP-D)' for central etiologies, and 'arginine vasopressin resistance (AVP-R)' for nephrogenic etiologies. "
7.	Prednisolone (Predate)FDA LinkGeneric 05/01/2009 - "Diabetes insipidus during pregnancy has a variety of causes, some that predate the pregnancy and others that begin during gestation. " 06/21/1957 - "[Diabetogenic action of prednisolone and its effect of diuresis in diabetes insipidus]." 07/07/1956 - "[Prednisolone in the treatment of diabetes insipidus; preliminary note]." 01/01/2007 - "Prednisolone therapy improved all of her clinical findings except diabetes insipidus. " 04/01/2006 - "Prednisolone therapy improved all of his clinical findings except diabetes insipidus. "
8.	Antidiuretic AgentsIBA 01/01/1994 - "Because of its antidiuretic effects, CBZ has been used successfully to treat diabetes insipidus centralis. " 12/01/2010 - "It is also known that Carba is used to decrease the urinary volume in Diabetes Insipidus (DI) because it has an antidiuretic effect. " 12/15/1972 - "[Antidiuretic effect of carbamazepin in diabetes insipidus]." 03/01/1969 - "Antidiuretic effect of sulfonylureas in idiopathic diabetes insipidus." 05/15/1953 - "[Antidiuretic effect in diabetes insipidus after p-carboxy-benzolsulfo-di-n-butylamide (longacid)]."
9.	ChlorpropamideFDA LinkGeneric 01/01/1991 - "The present in vitro microperfusion study examined whether chlorpropamide (CPM) has a direct effect on hydraulic conductivity (Lp x 10(-6) cm/atm.sec) and 14C-urea permeability (Pu x 10(-5) cm/sec) in the middle and distal inner medullary collecting duct (IMCD) obtained from acutely water-loaded Wistar rats and rats homozygous for diabetes insipidus (DI). " 01/01/1970 - "Studies on the mechanism of "chlorpropamide antidiuresis" in diabetes insipidus." 10/01/1983 - "Chlorpropamide action on renal concentrating mechanism in rats with hypothalamic diabetes insipidus." 02/15/1983 - "Chlorpropamide in pregnancy and transient neonatal diabetes insipidus." 03/01/1982 - "The use of chlorpropamide in diabetes insipidus in children."
10.	ElectrolytesIBA 07/01/2014 - "Moreover, along all cases, 19 were of improved vision and view, 2 of postoperative diabetes insipidus, and 1 of electrolyte imbalance. " 06/01/2018 - "Shortly after initiation, a massive rise in urine output ensued in addition to a change in his urine electrolyte studies, leading to the diagnosis of drug-induced diabetes insipidus. " 01/01/2023 - "Diabetes insipidus (DI) is a recognised complication of pituitary surgery, with diagnosis requiring clinical observation aided by plasma and urine electrolytes and osmolalities. " 06/01/2018 - "Active postoperative managements of diabetes insipidus and fluid and electrolyte imbalance may help patients with earlier recovery." 06/01/2018 - "Diabetes insipidus and fluid and electrolyte imbalance were timely controlled after surgery. "

Therapies and Procedures

1.	Therapeutics 10/01/1993 - "Understanding the nature of defective diabetes insipidus may ultimately lead to improved therapy." 11/01/1982 - "Oral antidiuretic therapy: studies in the diabetes insipidus rat." 06/01/1975 - "[Case of congenital diabetes insipidus--study on its therapy and physiopathology]." 03/01/2020 - "Both patients developed diabetes insipidus and required postoperative adjuvant DA therapy. " 01/01/2017 - "This article reviews the genetics of diabetes insipidus in the context of its diagnosis, clinical presentation, and therapy."
2.	Drug Therapy (Chemotherapy) 01/01/1996 - "CHOP chemotherapy proved to be an effective treatment for both the systemic and CNS involvement in our patient, but diabetes insipidus has persisted. " 11/01/2004 - "All three patients initially developed multifocal LCH lesions during early childhood (age <3 years) that responded well to chemotherapy; however, two of the three patients later developed diabetes insipidus. " 02/01/2018 - "Currently, children with organ involvement who do not have a good response to chemotherapy and have neurodegeneration or diabetes insipidus are the most problematic patients. " 01/01/2016 - "Special consideration must be given when managing diabetes insipidus in the adipsic patient, post-surgical patient, and in those undergoing chemotherapy or receiving medications that alter free water clearance." 07/01/2013 - "Response to surgery and chemotherapy and development of diabetes insipidus were the main outcome measures. "
3.	Radiotherapy 09/01/1995 - "Furthermore, low dose radiotherapy is a successful treatment for LCH-dependent masses in the hypothalamus; however, normalization or regression of CT abnormalities after radiotherapy did not affect the clinical diabetes insipidus status." 01/01/2020 - "Patients with NCAs had significantly higher recurrence (p = 0.021), adjuvant radiation therapy usage (p = 0.002), and postoperative diabetes insipidus (p = 0.028). " 06/01/2017 - "Although the majority of such patients are treated with radiation therapy, it remains unclear whether diabetes insipidus can be controlled by radiation therapy. " 10/01/2012 - "Gross-total was associated with increased rates of diabetes insipidus (OR 7.7, p = 0.05) compared with the combination of STR and radiotherapy (RT). " 05/01/2006 - "His diabetes insipidus persisted, and he underwent intensity-modulated radiation therapy to the sellar region. "
4.	Hypophysectomy 07/01/1988 - "For the surviving dogs in both studies, diabetes insipidus developed immediately after hypophysectomy and resolved within 2 weeks. " 02/01/1957 - "Further studies of diabetes insipidus following hypophysectomy in man." 09/01/2008 - "Diabetes insipidus is a clinical entity that is often seen in neurosurgical patients either during or immediately after transsphenoidal hypophysectomy. " 01/01/2006 - "A decrease in the function and the number of AVP-producing and -secreting magnocellular neurons after hypophysectomy, suggests that the clinical improvement of postoperative diabetes insipidus-like symptoms may not be related to the recovery of AVP secretion." 01/01/2006 - "Acute diabetes insipidus-like symptoms have been reported as a complication after hypophysectomy in dogs. "
5.	Conservative Treatment 01/01/2005 - "Six patients occurred transient diabetes insipidus, 2 patients with transient cerebrospinal rhinorrhoea cured by conservative therapy. " 07/09/2021 - "Transient diabetes insipidus was observed in 18 patients (24.6%); and rhinorrhoea, which was resolved with conservative treatment, in 4 (5.4%). " 05/01/2016 - "Diabetes insipidus uncovered during conservative management of complicated acute appendicitis." 01/01/2005 - "Conservative management of the congenital nasal pyriform aperture stenosis is adopted and management of diabetes insipidus is described. " 06/01/2001 - "Complications were follows: cerebrospinal fluid rhinorrhea in 2 cases, diabetes insipidus in 1 case, all of them were cured by conservative treatment; nasal septum perforation in 1 case, without any treatment. "