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Dermatomyositis (Dermatopolymyositis)

A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
Also Known As:
Dermatopolymyositis; Polymyositis Dermatomyositis; Dermatomyositis, Adult Type; Dermatomyositis, Childhood Type; Adult Type Dermatomyositides; Adult Type Dermatomyositis; Childhood Type Dermatomyositides; Childhood Type Dermatomyositis; Dermatomyositides; Dermatomyositides, Adult Type; Dermatomyositides, Childhood Type; Dermatopolymyositides; Polymyositis-Dermatomyositides; Polymyositis-Dermatomyositis
Networked: 2002 relevant articles (128 outcomes, 165 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Polymyositis
2. Interstitial Lung Diseases (Interstitial Lung Disease)
3. Systemic Lupus Erythematosus (Libman-Sacks Disease)
4. Inclusion Body Myositis
5. Polyneuropathies (Polyneuropathy)

Experts

1. Kuwana, Masataka: 21 articles (09/2015 - 06/2004)
2. Fujimoto, Manabu: 18 articles (01/2015 - 04/2003)
3. Mimori, Tsuneyo: 17 articles (01/2015 - 09/2004)
4. Lundberg, Ingrid E: 17 articles (11/2014 - 04/2002)
5. Dalakas, Marinos C: 16 articles (02/2015 - 06/2003)
6. Greenberg, Steven A: 15 articles (07/2014 - 06/2004)
7. Werth, Victoria P: 15 articles (07/2012 - 09/2002)
8. Muro, Yoshinao: 13 articles (09/2015 - 09/2010)
9. Miller, Frederick W: 13 articles (09/2014 - 07/2002)
10. Casciola-Rosen, Livia: 12 articles (12/2015 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dermatomyositis:
1. Intravenous Immunoglobulins (IVIG)FDA Link
2. Immunoglobulins (Immunoglobulin)IBA
3. Adrenal Cortex Hormones (Corticosteroids)IBA
4. Cyclosporine (Ciclosporin)FDA LinkGeneric
5. Methotrexate (Mexate)FDA LinkGeneric
6. Tacrolimus (Prograf)FDA LinkGeneric
7. rituximab (Mabthera)FDA Link
8. Cyclophosphamide (Cytoxan)FDA LinkGeneric
9. Prednisolone (Predate)FDA LinkGeneric
10. CortisoneIBA

Therapies and Procedures

1. Aftercare (After-Treatment)
2. Drug Therapy (Chemotherapy)
3. Transplants (Transplant)
4. Mesenchymal Stem Cell Transplantation
5. Resistance Training