Drug Eruptions (Drug Eruption)

Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.

Also Known As:

Drug Eruption; Maculopapular Drug Eruption; Maculopapular Exanthem; Morbilliform Drug Reaction; Morbilliform Exanthem; Drug Eruption, Maculopapular; Drug Eruptions, Maculopapular; Drug Reaction, Morbilliform; Drug Reactions, Morbilliform; Eruption, Drug; Eruption, Maculopapular Drug; Eruptions, Drug; Eruptions, Maculopapular Drug; Exanthem, Maculopapular; Exanthem, Morbilliform; Exanthems, Maculopapular; Exanthems, Morbilliform; Maculopapular Drug Eruptions; Maculopapular Exanthems; Morbilliform Drug Reactions; Morbilliform Exanthems; Reaction, Morbilliform Drug; Reactions, Morbilliform Drug; Dermatitis Medicamentosa; Dermatitis, Adverse Drug Reaction

Networked: 1612 relevant articles (18 outcomes, 42 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypersensitivity (Allergy)
2.	Systemic Inflammatory Response Syndrome (Sepsis Syndrome)
3.	Urticaria (Hives)
4.	Eosinophilia
5.	Fever (Fevers)

Experts

1.	Nakamura, Motonobu: 21 articles (07/2021 - 08/2009)
2.	Sawada, Yu: 21 articles (07/2021 - 08/2009)
3.	Yoshioka, Manabu: 13 articles (07/2021 - 01/2016)
4.	Katoh, Norito: 13 articles (01/2019 - 01/2006)
5.	Ohmori, Shun: 12 articles (01/2021 - 01/2016)
6.	Omoto, Daisuke: 11 articles (01/2021 - 01/2016)
7.	Shiohara, Tetsuo: 11 articles (11/2018 - 08/2002)
8.	Haruyama, Sanehito: 11 articles (07/2017 - 01/2016)
9.	Tokura, Yoshiki: 10 articles (01/2022 - 09/2006)
10.	Nakai, Noriaki: 9 articles (05/2016 - 12/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Drug Eruptions:

1.	Carbamazepine (Tegretol)FDA LinkGeneric 09/01/2015 - "Carbamazepine, although initially effective against PTS, caused drug eruption and she was unable to continue. " 09/22/2023 - "Carbamazepine-induced bullous fixed drug eruption: A case report." 08/18/2023 - "Retrieving domestic and foreign literature, it is not uncommon to report that carbamazepine causes drug eruption, including severe drug eruption, and there are obvious ethnic differences in the pathogenicity of HLA genotyping. " 05/01/2021 - "Carbamazepine-induced linear and bullous fixed drug eruption representing Wolf 's isotopic phenomenon." 10/01/1997 - "Carbamazepine-induced fixed drug eruption."
2.	Trichloroethylene (Trichloroethene)IBA 03/01/2015 - "To study the expression of C3aR and C5aR in trichloroethylene-sensitized mouse liver injury and discuss the pathogenesis of Dermatitis Medicamentosa-like of TCE (DMLT). " 10/01/2011 - "[Dynamic change study of dermatitis medicamentosa-like of trichloroethylene patients with liver damage]." 11/01/2011 - "[Analysis of subgroups of lymphocyte in peripheral blood among dermatitis medicamentosa-like of trichloroethylene patients and healthy exposed workers]." 10/01/2011 - "The early liver damage in dermatitis medicamentosa-like of trichloroethylene patients was serious, and repeatedly attacked, so we should lead to enough attention to the clinical work and prevention. " 01/01/2012 - "To study the better efficacy of clinic treatment for dermatitis medicamentosa like of trichloroethylene (DMLT) and observe the clinic efficacy of Xuebejing injection for DMLT patients with systemic inflammatory response syndrome (SIRS). "
3.	Anti-Bacterial Agents (Antibiotics)IBA 07/01/2023 - "The present case emphasizes that the close observation of patients with drug eruption induced by antibiotics is imperative. " 02/01/2023 - "The cutaneous microbiome of purpuric drug eruptions showed a significant increase in alpha diversity and a decrease in the relative abundance of Staphylococcus following antibiotic treatment. " 02/01/2023 - "Swabs were obtained from skin lesions and the nasal mucosa before and after antibiotic treatment of purpuric drug eruptions. " 02/01/2023 - "To characterize temporal changes in the skin and mucosal microbiomes before and after antibiotic treatment of EGFR inhibitor-related purpuric drug eruptions. " 02/01/2023 - "However, the longitudinal temporal shifts in the skin microbiome that occur before and after antibiotic treatment of purpuric drug eruptions remain largely unknown. "
4.	Imatinib Mesylate (Gleevec)FDA Link 04/01/2005 - "In this study, the characteristics of the cutaneous drug eruptions by STI571 were investigated. " 03/01/2017 - "We report a case of imatinib-induced lichenoid drug eruption (LDE), a rare cutaneous manifestation, along with a review of the literature." 03/01/2017 - "Imatinib mesylate-induced lichenoid drug eruption." 01/01/2015 - "We report a case of lichenoid drug eruption due to imatinib. " 01/01/2015 - "Lichenoid drug eruption due to imatinib mesylate."
5.	Amoxicillin (Wymox)FDA LinkGeneric 02/01/1976 - "(2) Amoxicillin was effective against: Staphylococcus aureus in 10 of 11 patients (90.9%) Staphylococcus epidermidis in 2 of 2 patients (100%) Streptococcus hemolyticus in 3 of 4 patients (75%) Streptococcus viridans in 1 of 1 patient (100%) Diplococcus pneumoniae in 1 of 1 patient (100%) (3) Although one patient developed drug eruption, there were no side effects that necessitated cessation of administration. " 12/01/2017 - "A pediatric case of selective fixed drug eruption to amoxicillin." 05/01/2013 - "Fixed drug eruption: a selective reaction to amoxicillin." 09/01/2008 - "Fixed drug eruption caused by amoxicillin-clavulanic." 09/01/1997 - "On reviewing the literature we have only found three reports of fixed drug eruption fue to amoxycillin."
6.	InterferonsIBA 01/01/2014 - "We evaluated the value of skin tests and the efficacy of a 12-step desensitization protocol to pegylated interferon (IFN) in patients with generalized drug eruptions due to IFNs. " 09/01/2020 - "Interferon-γ release test and TNF-α release test yielded different patterns in the present case, suggesting a different role for each in different drug eruption types." 07/01/2017 - "To our knowledge, this is the first known case of a lichenoid drug eruption from interferon in a seronegative HCV patient with metastatic RCC.</p> <p><em>J Drugs Dermatol. " 07/01/2015 - "Allergic sensitization to pegylated interferon-α results in drug eruptions." 05/01/2011 - "We herein describe a patient who developed morbilliform drug eruption under treatment with pegylated interferon. "
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/01/2017 - "The present case indicates that tumor necrosis factor-α antagonist is a safe, fast and effective treatment for severe drug eruption, but it is unable to prevent the rise of peripheral blood eosinophils." 07/15/2012 - "Lichenoid drug eruption is an uncommon, but previously reported, side effect of anti-tumor necrosis factor therapy. " 12/01/2017 - "Severe erythema multiforme-type drug eruption controlled by tumor necrosis factor-α antagonist: A case study." 12/01/2016 - "Pigmented lichenoid drug eruption: a new clinical presentation of interface dermatitis induced by anti-TNF alpha drugs." 07/01/2009 - "Eleven cases of lichen planus or lichenoid drug eruptions have been previously reported in patients taking TNF-alpha inhibitors, in addition to several cases of psoriasiform eruptions with a lichenoid histology. "
8.	Methotrexate (Mexate)FDA LinkGeneric 01/01/2021 - "Bullous drug eruption with low dose methotrexate." 01/18/2016 - "After she received 100 mg of methotrexate, drug eruptions were observed starting on day 3 and grew progressively worse. " 11/01/2013 - "Bullous drug eruption in a patient with psoriasis after a test dose of methotrexate." 09/01/2021 - "Further investigations are needed to evaluate the adverse cutaneous effects of spironolactone as well as the efficacy of systemic methotrexate in treating patients with a significant number of SCCs arising from lichenoid drug eruptions." 06/01/1987 - "Drug eruption caused by nitrazepam in a patient with severe pustular psoriasis successfully treated with methotrexate and etretinate."
9.	SteroidsIBA 01/01/2021 - "Skin rashes appeared two days later, and were treated with a topical steroid as just drug eruptions. " 05/01/2005 - "The histopathologic diagnosis of "drug eruption" is supported by the resolution of symptoms following discontinuation of MM. However, other possibilities include an immune-mediated process supported by the presence of lymphocytic infiltrations, the clinical appearance and the distribution of lesions (simulating a psoriatic-like dermatitis), as well as the marked response to steroids." 11/01/2018 - "Following the first administration, severe drug eruption occurred and despite temporary improvement seen by intravenous infusion of steroids in combination with oral administration and external use thereof, it relapsed in the early stages and toxic epidermal necrosis developed. " 01/01/2021 - "Lichenoid drug eruptions associated with PD-1 inhibitors show rapid improvement with high potency topical steroids and do not require cessation of the offending drug. " 01/01/2009 - "He had been treated with oral retinoids, steroids, and phototherapy for the diagnoses of drug eruption, pityriasis rubra pilaris, and exfoliative dermatitis at other hospitals. "
10.	Immune Checkpoint InhibitorsIBA 01/01/2021 - "Cutaneous adverse events, such as lichenoid drug eruptions, are well-known common side effects associated with PD-1 inhibitors. " 09/01/2020 - "However, immune checkpoint inhibitors are associated with various cutaneous adverse events, one of which is psoriasiform drug eruption. " 11/27/2023 - "Immune checkpoint inhibitor-induced lichenoid drug eruption-sparing scar burns." 11/01/2022 - "There were differences in time to onset after immune checkpoint inhibitor initiation, with a median of approximately 1 month (erythema multiforme, Stevens‒Johnson syndrome, and toxic epidermal necrolysis), 2 months (drug eruption and eczematous dermatitis), 4 months (lichenoid dermatitis), and 5‒6 months (bullous pemphigoid and vitiligo). " 01/01/2021 - "Lichenoid drug eruptions associated with PD-1 inhibitors show rapid improvement with high potency topical steroids and do not require cessation of the offending drug. "

Therapies and Procedures

1.	Therapeutics 01/01/2023 - "Lichenoid drug eruption in patients on anti-TB therapy in a high HIV prevalence setting." 06/27/2022 - "Anti-CMV therapy is highly recommended for patients with CMV-IRIS or severe drug eruption who have risk factors for CMV reactivation resulting in fatal outcomes." 01/01/2022 - "Lichenoid drug eruptions have been implicated as the side effects of anti-retroviral therapy. " 11/01/2021 - "Drug eruptions with novel targeted therapies - immune checkpoint and EGFR inhibitors." 10/01/2021 - "We report a case of fixed drug eruption in a 58-year-old lady treated for diabetes with four pharmacologically different anti-diabetic agents that were used at separate times of therapy. "
2.	Oral Administration 12/01/2012 - "Fixed drug eruption (FDE) usually develops after oral administration and is described as a cutaneous reaction recurring at the same location each time the drug is taken. " 07/01/2013 - "After the surgery, he was treated with oral administration of S-1 as postoperative adjuvant chemotherapy, but stopped after five months because of a drug eruption and general fatigue. " 11/01/2018 - "Following the first administration, severe drug eruption occurred and despite temporary improvement seen by intravenous infusion of steroids in combination with oral administration and external use thereof, it relapsed in the early stages and toxic epidermal necrosis developed. " 12/01/2023 - "To report a 24-year-old man who developed exanthematous drug eruptions in general and swelling sensation of the hands after first dose of oral administration of medicines for Helicobacter pylori infection 7 h later, who was finally confirmed with delayed-type IV allergic reaction to furazolidone by provocation tests. " 03/01/2002 - "We now describe recall dermatitis along the residual cutaneous lesions of a previous thoracic herpes zoster in a patient who developed a drug eruption after oral administration of aciclovir. "
3.	Chemoradiotherapy 12/01/2014 - "We report two cases of cutaneous drug eruption caused by tmz during and after radiochemotherapy treatment. " 04/01/2010 - "Concurrent chemoradiotherapy is safe and effective for squamous cell carcinoma of the anal canal, but care is required to prevent drug eruption during treatment." 04/01/2010 - "We report a case of drug eruption (erythema multiforme type) in a 54-year-old woman, following concurrent chemoradiotherapy for squamous cell carcinoma of the anal canal. " 04/01/2010 - "[Drug eruption (erythema multiforme type) following chemoradiotherapy with mitomycin C and 5-fluorouracil administration for squamous cell carcinoma of the anal canal]."
4.	Conservative Treatment 06/17/2015 - "drug eruptions, allergic eczemas, irritative dermatitis/vulvitis, Behcet's Syndrome and pemphigus/pemphigoid usually respond well to conservative treatment. " 09/25/2021 - "During the treatment of imatinib, the incidence of grade 3 or higher adverse reactions was 22.1% (15/68), including 12 cases of grade 3 neutropenia and 3 of grade 4 drug eruption, which were all relieved after conservative treatment. "
5.	Self Medication 07/01/2008 - "The present study was carried out to determine the age, sex incidence and clinical pattern of drug eruptions, to recognize offending drugs (self medication or prescribed), to evaluate mortality and morbidity associated with drugs, to educate the patients, and to avoid self-administration of drugs and re-administration of the offending drugs. " 04/01/2004 - "All the patients presented one or more fixed drug eruption reactivation lesions induced by sulfaguanidine as self-medication for diarrhea. "