Deoxyribonucleosides

02/19/1996 - "At supralethal exposures of gamma-irradiation, Deoxyribonucleosides and DNA are equally effective in reversing radiation damage which otherwise leads to chromosome breakage. "

05/01/1999 - "In view of their safety, availability, and efficacy, deoxyribonucleosides hold considerable promise for improving healing of chronic wounds."
05/01/1999 - "We hypothesized that a topical mixture of purified deoxyribonucleosides would accelerate wound healing in an open wound model. "
05/01/1999 - "Topically applied deoxyribonucleosides reproducibly accelerate wound healing in normal and ischemic wounds, and to a magnitude equivalent to that of recombinant growth factors such as platelet-derived growth factor, previously studied in this model. "
05/01/1999 - "An equiweight mixture containing all 4 of the major deoxyribonucleosides (deoxyadenosine, deoxycytidine, deoxyguanosine, and thymidine), designated PN105, or other subgroups of deoxyribonucleosides, or vehicle (saline) was applied to wounds on 1 ear every 2 days, with the other ear serving as a control. "

01/01/2017 - "Reciprocally, ectopic expression of TS and RR or addition of deoxyribonucleosides resulted in suppression of senescence phenotypes in normal or tumor cells caused by overexpression of activated HRAS or depletion of C-MYC, respectively. "
07/30/1965 - "Inhibition by halogenated deoxyribonucleosides of the production of tumors by a polyoma virus."
11/01/1991 - "Inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted skin tumor formation in mice by 16 alpha-fluoro-5-androsten-17-one and its reversal by deoxyribonucleosides."
12/21/1982 - "The cancer chemotherapeutic drug cis-diamminedichloroplatinum (II) (cis-DDP) was reacted with deoxyribonucleosides, and the products were separated by high-pressure liquid chromatography and characterized by 1H nuclear magnetic resonance. "
03/07/1997 - "The antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has been shown previously to be enhanced markedly by the co-administration of pyrimidine deoxyribonucleosides (Lin and Prusoff, Cancer Res 47: 394-397, 1987). "

05/01/2015 - "PLD1 inhibition of HIV-1 infection was partially rescued by adding exogenous deoxyribonucleosides that bypass the need for de novo dNTP synthesis. "
07/01/2008 - "We conclude that chronic OV infection through oxidative/nitrative stress leads to increased urinary excretion of the etheno-bridged deoxyribonucleosides, reflecting high LPO-derived DNA damage in vivo. "
06/09/1972 - "Inhibition of the catabolism of deoxyribonucleosides in Escherichia coli after infection by T 4 phage."
09/01/2020 - "5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection."

01/15/1987 - "Three levels of 1,3-bis(2-chloroethyl)-1-nitrosourea (10, 15, and 20 mg/kg) were coadministered to mice bearing the L1210 leukemia or the B16/F10 melanoma with each of the deoxyribonucleosides (2 g/kg). "
06/01/1989 - "Reduced DNA damage induced in human melanoma cells by dacarbazine in the presence of deoxyribonucleosides."
09/01/1979 - "The effects of purine deoxyribonucleosides on bromodeoxyurdine (BrdU) mutagenesis in Syrian hamster melanoma cells were determined. "