Deoxycholic Acid (Sodium Deoxycholate)

A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
Also Known As:
Sodium Deoxycholate; Choleic Acid; Deoxycholic Acid, 12beta-Isomer; Deoxycholic Acid, 3beta-Isomer; Deoxycholic Acid, 5alpha-Isomer; Deoxycholic Acid, Disodium Salt; Deoxycholic Acid, Magnesium (2:1) Salt; Deoxycholic Acid, Monoammonium Salt; Deoxycholic Acid, Monopotassium Salt; Deoxycholic Acid, Monosodium Salt; Deoxycholic Acid, Sodium Salt, 12beta-Isomer; Dihydroxycholanoic Acid; Lagodeoxycholic Acid; 12beta-Isomer Deoxycholic Acid; 3beta-Isomer Deoxycholic Acid; 5alpha-Isomer Deoxycholic Acid; Acid, 5alpha-Isomer Deoxycholic; Acid, Choleic; Acid, Deoxycholic; Acid, Desoxycholic; Acid, Dihydroxycholanoic; Acid, Lagodeoxycholic; Deoxycholate, Sodium; Deoxycholic Acid, 12beta Isomer; Deoxycholic Acid, 3beta Isomer; Deoxycholic Acid, 5alpha Isomer; Deoxycholate; Desoxycholic Acid; Cholan-24-oic acid, 3,12-dihydroxy-, (3alpha,5beta,12alpha)-
Networked: 627 relevant articles (27 outcomes, 53 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Dowling, R H: 10 articles (05/2005 - 01/2000)
2. Murphy, G M: 9 articles (05/2005 - 06/2000)
3. Bernstein, Carol: 8 articles (07/2014 - 12/2002)
4. Bernstein, Harris: 8 articles (07/2014 - 12/2002)
5. Walsh, Thomas J: 7 articles (10/2014 - 01/2002)
6. Payne, Claire M: 7 articles (08/2011 - 12/2002)
7. Byun, Youngro: 6 articles (11/2012 - 04/2007)
8. Garewal, Harinder: 6 articles (01/2009 - 12/2002)
9. Thomas, L A: 6 articles (05/2005 - 01/2000)
10. Veysey, M J: 6 articles (05/2005 - 09/2000)

Related Diseases

1. Infection
2. Visceral Leishmaniasis (Kala Azar)
3. Neoplasms (Cancer)
4. Cryptococcal Meningitis
5. Aspergillosis
02/01/2012 - "In this retrospective study we evaluated the impact of amphotericin B (AmB) deoxycholate inhalation prophylaxis on invasive aspergillosis (IA) in 611 allogeneic stem cell transplant (alloSCT) recipients and their tolerance of the inhalations. "
10/01/2006 - "Organ transplant recipients are at increased risk for severe invasive aspergillosis, and amphotericin deoxycholate has been the standard treatment for many years. "
11/01/2004 - "Here we examined the protective effects of administration of PTX3 alone or together with deoxycholate amphotericin B (Fungizone) or liposomal amphotericin B (AmBisome) against invasive aspergillosis in a murine model of allogeneic bone marrow transplantation. "
03/01/2004 - "We compared various amphotericin B formulations (no treatment or 0.8 mg of Fungizone [conventional deoxycholate amphotericin B] per kg of body weight, or 0.8, 4, or 8 mg of Amphocil, AmBisome, or Abelcet per kg of body weight) for treatment of systemic murine aspergillosis. "
02/01/2005 - "The results show that: (a) neutrophil activation by Aspergillus occurs through TLR signalling pathways differently affecting the oxidative and non-oxidative mechanisms of the killing machinery; (b) by diverting signalling from TLR-2 to TLR-4, liposomes of AmBisome activate neutrophils to an antifungal state while attenuating the pro-inflammatory effects of deoxycholate amphotericin B; (c) this translates in vivo to the optimization of the AmBisome therapeutic efficacy in mice with aspergillosis. "

Related Drugs and Biologics

1. Amphotericin B (Amphotericin)
2. liposomal amphotericin B
3. phospholipid emulsion soybean oil (Intralipid)
4. Bile Acids and Salts (Bile Acids)
5. Cholesterol
6. Cholates
7. Micelles
8. Liposomes (Liposome)
9. Simvastatin (Zocor)
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Bone Marrow Transplantation (Transplantation, Bone Marrow)
3. Aftercare (After-Treatment)
4. Ligation
5. Intra-Articular Injections