|1.||Chung, Kyu Hyuck: 1 article (06/2011)|
|2.||Han, Eunyoung: 1 article (06/2011)|
|3.||In, Sanghwan: 1 article (06/2011)|
|4.||Lee, Sooyeun: 1 article (06/2011)|
|5.||Chung, Heesun: 1 article (06/2011)|
|6.||Choi, Hwakyung: 1 article (06/2011)|
|7.||Maravelias, Constantinos P: 1 article (08/2010)|
|8.||Nikolaou, Panagiota D: 1 article (08/2010)|
|9.||Athanaselis, Sotirios A: 1 article (08/2010)|
|10.||Pistos, Constantinos M: 1 article (08/2010)|
|1.||Renal Insufficiency (Renal Failure)
01/01/1984 - "Clearance of pharmacologically active unbound desmethyldiazepam was reduced in renal failure patients as opposed to controls, and free fraction in serum was greater. "
01/01/1984 - "Clorazepate dipotassium and diazepam in renal insufficiency: serum concentrations and protein binding of diazepam and desmethyldiazepam."
|2.||Substance Withdrawal Syndrome (Withdrawal Symptoms)
02/01/2004 - "Effective doses were 0.07 to 0.56 mg/kg, and plasma effective levels of chloro-N-desmethyldiazepam were 12.3-115.1 ng/mL. Cloxazolam may be an effective and safe antiepileptic for intractable epilepsy, and should be used as an adjunct to other antiepileptic drugs or administered after other agents."
04/01/1988 - "Abstinence was evaluated using a Nordiazepam Precipitated Abstinence Scale (NPAS) of various signs of abstinence and by counting seizure episodes. "
03/01/1985 - "These beneficial effects may reflect a heightened response by limbic seizure foci to the anticonvulsant effects of nordiazepam, or a potentiation of its anticonvulsant effects through attenuating patient anxiety."
07/28/1976 - "The distribution pattern of diazepam and N-desmethyldiazepam offers a rationale for its efficacy in inhibiting seizures spreading and for the lack of effect on primary foci discharges."
10/01/1991 - "This abstinence as measured by the NPAS score was more severe in diazepam- and halazepam-dependent than in nordiazepam-dependent dogs whereas the incidence of precipitated clonic seizures was greater in the diazepam- and nordiazepam-dependent than in the halazepam-dependent dogs. "
09/01/1976 - "A study was made of the interrelationship between the minimal effective doses of pseudoclonic and clonico-tonic convulsions, and also tonic extension caused by the intravenous injection of corazol to mice and the effect of anticonvulsive action of sulazepam and its metabolites (diazepam, desmethyldiazepam and oxadiazepam) on this process. "
|5.||Body Weight (Weight, Body)
12/01/1986 - "In Study Two, desmethyldiazepam kinetics were compared in eight cigarette smokers (mean, 19 cigarettes/day) and in 11 nonsmoking controls matched for age, sex, and body weight. "
08/01/1997 - "Diazepam terminal half-life, volume of distribution, clearance, free fraction, unbound volume of distribution, free clearance, peak desmethyldiazepam concentration, and area under the desmethyldiazepam concentration-time curve were determined after i.v. administration of 0.25 mg of diazepam/kg of body weight to foals at 4, 21, 42, and 84 days of age. "
01/01/1995 - "Dosages were: clorazepate dipotassium: body weight < 55 kg: 10 mg; body weight > 55 kg: 20 mg; nordiazepam: 1 gtt/kg; 5 mg = 24 gtt). "
11/01/1985 - "Signs of abstinence such as tremor, hot foot walking and twitches and jerks were more frequently observed in N-desmethyldiazepam-dependent dogs than in diazepam-dependent dogs as were decreases in food and water intake and in body weight. "
03/01/1998 - "Changes in body weight (BW) in female rats treated for 5 weeks (wk) with weekly subcutaneous implantation of silastic capsules containing different benzodiazepines (BZs): diazepam (DZ) 90, 180, 360 and 540 mg wk-1; nordiazepam (ND) 600 mg wk-1; oxazepam (OX) 600 mg wk-1 and flunitrazepam (FN) 540 mg wk-1 and in male rats exposed to DZ (540 mg wk-1) were evaluated herein. "
|2.||Anticonvulsants (Antiepileptic Drugs)
|7.||Pyridostigmine Bromide (Pyridostigmine)
|8.||gamma-Aminobutyric Acid (GABA)