Decerebrate State

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59 relevant articles (3 outcomes, 0 trials/studies) found for this Disease

Description: A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)

Also Known As:

Decerebrate Posturings; Decerebrate Rigidity; Decerebrate States; Decorticate Rigidities; Decorticate States; Posturing, Decerebrate; Posturings, Decerebrate; Rigidities, Decorticate; State, Decerebrate; States, Decerebrate; Decerebrate Posturing; Decorticate Rigidity; Decorticate State; Rigidity, Decerebrate; Rigidity, Decorticate

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3406

Neurologic Manifestations: 2876

Decerebrate State: 59

Signs and Symptoms Pathological Conditions

Signs and Symptoms

Neurologic Manifestations: 2876

Decerebrate State: 59

Related Diseases

1.	Fever (Fevers)
2.	Heart Arrest (Cardiac Arrest)
3.	Coma (Comas)
4.	Intracranial Hypertension
5.	Ventricular Fibrillation
18 Diseases and 13 more articles analyzed in the Research Interface, order at left...

Experts

1.	Kao, Chuen-Der: 1 article (01/2008)
2.	Liao, Kwong-Kum: 1 article (01/2008)
3.	Lai, Kuan-Lin: 1 article (01/2008)
4.	Chang, Jiun-Bin: 1 article (01/2008)
5.	Wu, Zin-An: 1 article (01/2008)
6.	Chen, Jen-Tse: 1 article (01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Decerebrate State:

1.	Oxazolidinones (2 Oxazolidone)IBA 09/01/1986 - "Some oxazolidinones markedly reduced the severity of this decerebrate rigidity in a dose-dependent manner, (4S,5R)-4-(2-methylpropyl)-3- [3-(perhydroazepin-1-yl)propyl]-5-phenyl-1,3-oxazolidin-2-on e (MLV-6976) being the most potent" 09/01/1986 - "In addition to the oxazolidinones, an aminoalcohol derivative, (1RS,2SR)-5-methyl-1-phenyl-2-(3-piperidinopropylamino )hexan-1-ol (MLV-5860) also reduced the rat decerebrate rigidity" 01/01/1988 - "Pharmacology of oxazolidinones in rat decerebrate rigidity, with reference to their glutamate blocking action." 09/01/1986 - "A new class of potent centrally acting muscle relaxants: pharmacology of oxazolidinones in rat decerebrate rigidity." 06/01/1989 - "Kynurenate, ketamine, (4S, 5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl- 1,3- oxazolidin-2-one hydrochloride (MLV-6976), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclo-hepten-5,10-imine maleate (MK-801), 3-((/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) and DL-2-amino-7-phosphonoheptanoic acid (APH) reduced the severity of decerebrate rigidity in a dose-dependent manner, although there was a large variability in the effective doses" Get all the results and reference details, order at left...
2.	Propranolol (Inderal)FDA LinkGeneric 06/01/1991 - "3. In contrast to these findings, injection in other experiments of 0.25-0.50 microliter of a solution of propranolol at the concentration of 16 micrograms/microliter of saline increased the extensor tonus in the ipsilateral limbs, while the decerebrate rigidity either remained unmodified or slightly decreased in the contralateral limbs" 07/01/1994 - "Central fevers after TBI have been reported to have been treated successfully with propranolol in two children with decerebrate posturing" Get all the results and reference details, order at left...
3.	Kynurenic Acid (Kynurenate)IBA 06/01/1989 - "Kynurenate, ketamine, (4S, 5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl- 1,3- oxazolidin-2-one hydrochloride (MLV-6976), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclo-hepten-5,10-imine maleate (MK-801), 3-((/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) and DL-2-amino-7-phosphonoheptanoic acid (APH) reduced the severity of decerebrate rigidity in a dose-dependent manner, although there was a large variability in the effective doses" Get all the results and reference details, order at left...
4.	Ketamine FDA LinkGeneric 06/01/1989 - "Kynurenate, ketamine, (4S, 5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl- 1,3- oxazolidin-2-one hydrochloride (MLV-6976), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclo-hepten-5,10-imine maleate (MK-801), 3-((/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) and DL-2-amino-7-phosphonoheptanoic acid (APH) reduced the severity of decerebrate rigidity in a dose-dependent manner, although there was a large variability in the effective doses" Get all the results and reference details, order at left...
5.	3- (2- carboxypiperazin- 4- yl)propyl- 1- phosphonic acid (CPP)IBA 06/01/1989 - "Kynurenate, ketamine, (4S, 5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl- 1,3- oxazolidin-2-one hydrochloride (MLV-6976), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclo-hepten-5,10-imine maleate (MK-801), 3-((/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) and DL-2-amino-7-phosphonoheptanoic acid (APH) reduced the severity of decerebrate rigidity in a dose-dependent manner, although there was a large variability in the effective doses" Get all the results and reference details, order at left...
6.	maleic acid (maleate)IBA 06/01/1989 - "Kynurenate, ketamine, (4S, 5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl- 1,3- oxazolidin-2-one hydrochloride (MLV-6976), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclo-hepten-5,10-imine maleate (MK-801), 3-((/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) and DL-2-amino-7-phosphonoheptanoic acid (APH) reduced the severity of decerebrate rigidity in a dose-dependent manner, although there was a large variability in the effective doses" Get all the results and reference details, order at left...
7.	Diazepam (Valium)FDA LinkGeneric 11/01/1964 - "ACTION OF VALIUM ON EXPERIMENTAL DECEREBRATE RIGIDITY AND ON RIGIDITY OF CHILDREN WITH CERBRAL MOTOR DISEASE.]" 09/01/1979 - "Effects of diazepam and baclofen on the anemic decerebrate rigidity in rats were studied by using the drugs that modify GABAergic mechanisms of deplete catecholamine" 09/01/1979 - "Effects of diazepam and baclofen on the anemic decerebrate rigidity in rats (author's transl)]" 11/01/1983 - "Diazepam and chlordiazepoxide were of limited potency in morphine-induced rigidity and decerebrate rigidity, but were potent on the polysynaptic reflex" 01/01/1993 - "Local cerebral glucose utilization in rats with decerebrate rigidity and effects of centrally acting muscle relaxants, diazepam and tizanidine." Get all the results and reference details, order at left...
8.	Central Muscle RelaxantsIBA 01/01/1993 - "These results suggest that the vestibular and cerebellar nuclei are the possible sites responsible for the development of decerebrate rigidity and the action of some centrally acting muscle relaxants." 12/01/1974 - "Effects of some antiparkinsonism drugs and centrally acting muscle relaxants on the intercollicular decerebrate rigidity in rats." 09/01/1986 - "A new class of potent centrally acting muscle relaxants: pharmacology of oxazolidinones in rat decerebrate rigidity." 01/01/1993 - "Local cerebral glucose utilization in rats with decerebrate rigidity and effects of centrally acting muscle relaxants, diazepam and tizanidine." Get all the results and reference details, order at left...
9.	Serotonin (5 Hydroxytryptamine)IBA 11/01/1988 - "Following intravenous administration of the serotonin precursor 5-hydroxytryptophan, mimicking the tonic activity of these pathways in the decerebrate state, it was again possible to elicit the long-lasting excitability increase by a train of impulses in Ia afferents" 05/01/1979 - "neurones.2. In the decerebrate state without cooling the spinal cord 13% of the cells (eleven out of eighty-three) responded to intra-arterial injection of bradykinin, 33% (twenty-two out of sixty-nine) to 5-hydroxytryptamine, and 38% (thirty-five out of ninety-one) to potassium injection.3. The general time course and the latency of the responses of s.c.t" 05/01/1979 - "1. In cats, extracellular micro-electrode recordings were made from axons of the spinocervical tract (s.c.t.) in both the decerebrate state and during cold block of the spinal cord (reversible spinal state) to examine the effects of intra-arterial injection of algesic agents (bradykinin, potassium, 5-hydroxytryptamine) into the gastrocnemius-soleus (g.s.) muscle on the discharge behaviour of s.c.t" Get all the results and reference details, order at left...
10.	Phenytoin (Dilantin)FDA LinkGeneric 01/01/1985 - "Phenytoin (DPH) was evaluated for its capacity to reduce several motor manifestations of decerebrate rigidity in the cat" 09/01/1976 - "In cats decerebrated by a midcollicular section, decerebrate rigidity developed that was not alleviated by phenytoin even in doses as great as 60 mg per kilogram" 09/01/1976 - "In the presence of 20 mg per kilogram phenytoin, however, as little as 0.1 mg per kilogram chlorpromazine markedly reduces decerebrate rigidity" 09/01/1976 - "Suppression of decerebrate rigidity by phenytoin and chlorpromazine." Get all the results and reference details, order at left...
63 Drugs and Important Bio-Agents and 53 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Resuscitation 01/01/1970 - "A clinico-morphologic analysis of decerebrate rigidity arising following resuscitation]" 01/01/1988 - "We report the case of an 88-year-old man who had a 5- to 6-minute cardiac arrest and then had decerebrate posturing during the post-resuscitation period, indicating that he had suffered a significant ischemic/anoxic insult" Get all the results and reference details, order at left...
2.	Renal Replacement Therapy (Therapies, Renal Replacement) 03/01/2006 - "We report on the case of a patient who suffered a cardiac arrest in ventricular fibrillation (VF), leading to a decerebrate state, who made a rapid complete neuronal recovery following the institution of continuous renal replacement therapy (CRRT)" Get all the results and reference details, order at left...
3.	Liver Transplantation 08/01/1995 - "RESULTS: From a comatose state with seizures and decerebrate posturing, the patient woke up the day after heterotopic auxiliary liver transplantation" Get all the results and reference details, order at left...
4.	Artificial Respiration (Mechanical Ventilation) 08/26/1985 - "Decerebrate posturing, a decrease in value (mean +/- SEM) of arterial oxygen tension (Pa02) of 26 +/- 1 torr, and an increase in arterial carbon dioxide tension (PaCO2) of 11 +/- 1 torr occurred in the dogs, which were supported by mechanical ventilation" Get all the results and reference details, order at left...
5.	Electrodes (Electrode) 05/01/1979 - "1. In cats, extracellular micro-electrode recordings were made from axons of the spinocervical tract (s.c.t.) in both the decerebrate state and during cold block of the spinal cord (reversible spinal state) to examine the effects of intra-arterial injection of algesic agents (bradykinin, potassium, 5-hydroxytryptamine) into the gastrocnemius-soleus (g.s.) muscle on the discharge behaviour of s.c.t" Get all the results and reference details, order at left...
7 Therapies and Procedures and 8 more articles analyzed in the Research Interface, order at left...

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