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Debrisoquin (Debrisoquine)

An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Also Known As:
Debrisoquine; Tendor; 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-
Networked: 151 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Branch, Robert A: 2 articles (02/2011 - 09/2006)
2. Zhang, Ran-Ran: 1 article (01/2015)
3. Ueno, Yasuharu: 1 article (01/2015)
4. Taniguchi, Hideki: 1 article (01/2015)
5. Tsuchida, Tomonori: 1 article (01/2015)
6. Nie, Yun-Zhong: 1 article (01/2015)
7. Li, Bin: 1 article (01/2015)
8. Zheng, Yun-Wen: 1 article (01/2015)
9. Buch, Shama C: 1 article (02/2011)
10. Stewart, Nicolas A: 1 article (02/2011)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Lung Neoplasms (Lung Cancer)
3. Parkinson Disease (Parkinson's Disease)
4. Body Weight (Weight, Body)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Guanethidine
2. Bethanidine (Batel)
3. Cytochrome P-450 CYP2D6 (CYP2D6)
4. Cytochrome P-450 Enzyme System (Cytochrome P450)
5. Methyldopa (Aldomet)
6. Mephenytoin (Mesantoin)
7. Sparteine
8. Dapsone
9. Caffeine (No Doz)
10. Norepinephrine (Noradrenaline)

Related Therapies and Procedures

1. Stem Cell Transplantation
2. Transplantation (Transplant Recipients)
3. Renal Dialysis (Hemodialysis)
4. Drug Therapy (Chemotherapy)
5. Oral Administration