|4.||Cardiac Arrhythmias (Arrythmia)
|1.||Maron, Barry J: 34 articles (09/2015 - 03/2002)|
|2.||Basso, Cristina: 15 articles (08/2015 - 07/2002)|
|3.||Thiene, Gaetano: 14 articles (11/2014 - 07/2002)|
|4.||Maron, Martin S: 13 articles (11/2015 - 07/2006)|
|5.||Spirito, Paolo: 12 articles (08/2015 - 10/2004)|
|6.||Haas, Tammy S: 11 articles (08/2015 - 08/2005)|
|7.||Ackerman, Michael J: 11 articles (08/2014 - 06/2002)|
|8.||Chen, S R Wayne: 10 articles (01/2015 - 08/2002)|
|9.||Sinagra, Gianfranco: 10 articles (12/2014 - 07/2002)|
|10.||Wanner, Christoph: 10 articles (10/2014 - 09/2008)|
|1.||Amiodarone (Amiodarona)FDA LinkGeneric
04/01/1994 - "beta-Blockers and amiodarone are effective in primary prevention of sudden death in selected populations. "
05/01/2007 - "The object of this study was to determine the incidence, dose, and time until onset of bilateral vision loss from amiodarone as a secondary end point in an investigation of amiodarone's role in preventing sudden death. "
05/01/1999 - "Assuming NSVT as a potential prognostic marker for sudden death, amiodarone treatment may have exerted a beneficial effect in these patients, but this statement is only a presumption due to the limitations of our study. "
03/11/1999 - "Several trials have evaluated the role of amiodarone in decreasing mortality in patients at high risk of developing sudden death. "
03/11/1999 - "Amiodarone and "primary" prevention of sudden death: critical review of a decade of clinical trials."
06/04/1992 - "Antiarrhythmic drugs have not been shown to be effective for preventing sudden death, although there are as yet no well-controlled randomized trials. "
11/01/1992 - "Several trials investigating the efficacy of antiarrhythmic drugs in decreasing sudden death have yielded disappointing results. "
07/01/1979 - "Thus, it may serve as a model to study sudden death and the efficacy of antiarrhythmic drugs."
09/01/2002 - "The efficacy of antiarrhythmic drugs and devices in preventing sudden death and reducing total mortality is uncertain. "
07/01/1996 - "Prevention of sudden death, reduction in total mortality, or improvement in symptoms remain the only benefits of antiarrhythmic drugs. "
|3.||Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
08/01/2003 - "Emphasis on foods rich in n-3 fatty acids shows promise for reducing cardiovascular outcomes, particularly sudden death."
03/01/2004 - "Clinical studies show that N-3 PUFA or fish oil supplementation appears to reduce mortality and sudden death. "
09/01/2002 - "However, we believe that large-scale prospective multicentric randomized trials aimed at preventing sudden death in high-risk patients as well as at testing the effects of n-3 PUFA in patients with intracoronary devices and sustained ventricular arrhythmias, are a major direction to be followed to better understand the n-3 PUFA and sudden death issue."
03/01/2002 - "The hypothesis that a protection from sudden death occurs because of antiarrhythmic effects of omega-3 fatty acids is supported by studies on cellular and animal models. "
06/01/2013 - "Recent randomized evidence indeed fails to support that n-3 fatty acids may prevent sudden death in nonrenal patients. "
|4.||Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
11/01/1981 - "Pretreatment with aspirin, which uniformly inhibited platelet aggregation, was associated with a reduced incidence of sudden death (25%), but the difference between aspirin-treated and control animals lacked statistical significance. "
05/01/2010 - "Detecting an interaction between acetylsalicylic acid and PF4-H-ABs regarding sudden death and mortality, we found that the association between PF4-H-ABs and outcomes was restricted to patients with acetylsalicylic acid use, most likely because of indication bias. "
06/03/1995 - "Stable angina is an ideal application for low-dose aspirin with an improvement in combined incidence of myocardial infarction and sudden death of 34%. "
07/01/2003 - "Autopsy-proven shunt thrombosis is one of the leading causes of interim sudden death, and aspirin therapy may not be helpful. "
02/15/2001 - "Sudden death occurred seven days after acute gastrointestinal bleeding and subsequent interruption of aspirin therapy. "
|5.||Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
12/01/2006 - "The use of highly concentrated and purified omega-3 polyunsaturated fatty acids (n-3 PUFAs), in addition to standard secondary prevention after MI, results in a significant reduction in the risk of sudden death. "
01/01/2006 - "The use of highly concentrated and purified omega-3 polyunsaturated fatty acids (n-3 PUFAs), in addition to standard secondary prevention after MI, results in a significant reduction in the risk of sudden death versus no n-3 PUFAs. "
02/01/2011 - "The goal of this study was to determine the mechanisms of n-3 polyunsaturated fatty acids (n-3 PUFA) on anti-arrhythmias and prevention of sudden death. "
04/01/2010 - "Risk of sudden death is associated with a low blood level of n-3 polyunsaturated fatty acids. "
06/01/2006 - "Omega-3 polyunsaturated fatty acids (omega3-PUFAs) from fish oil reduce the risk of sudden death presumably by preventing life-threatening arrhythmias. "
|6.||Propranolol (Inderal)FDA LinkGeneric
11/01/1978 - "All patients with this disorder should be treated with propranolol; surgical intervention, although it does not totally abolish the risk of sudden death, appears to offer symptomatic improvement in most cases over a long-term follow-up period."
06/01/1982 - "Nineteen of the 78 patients (24%) were taking propranolol in apparently adequate dosages, indicating that this drug does not provide absolute protection against sudden death. "
02/01/1998 - "The results of the Cox regression analysis, adjusting for all baseline variables with p values <0.25, showed the relative risk of overall mortality rate and the relative risk of sudden death were 2.13 ( 1.22, 3.70) and 2.56 (1.27, 5.26), respectively, for the placebo group compared with the propranolol group. "
02/01/1998 - "Sudden death in the placebo arm was 9.7% compared with 4.7% in the propranolol group (p = 0.012, log rank test). "
07/15/1990 - "Mortality was 7.8% (sudden death 4.8%) in the propranolol group and 7.9% (sudden death 4.8%) in the placebo group (p greater than 0.99, log rank test). "
12/01/1980 - "In multivariate Cox regression, controlling for age, blood pressure, serum cholesterol, cigarettes smoked per day and relative weight, heart rate is a significant risk factor for sudden CHD death and non-CVD death in two of the three studies, with the association with sudden death being U-shaped in one of the studies. "
05/01/2013 - "Increased LCAT activity measured as a serum cholesterol esterification rate was a risk for CHD and sudden death in a Japanese general population."
04/20/1999 - "Resting heart rate, systolic or diastolic blood pressure, tobacco consumption, body mass index, diabetes status, serum cholesterol, and parental history of sudden death were independent factors associated with sudden death during follow-up (23 years on average). "
12/01/1990 - "In asymptomatic persons the risk of sudden death varies over a wide range in relation to risk factors such as systolic blood pressure, serum cholesterol, cigarette smoking, heart rate, electrocardiographic abnormality and relative weight. "
05/01/2013 - "Increased serum cholesterol esterification rates predict coronary heart disease and sudden death in a general population."
|8.||Spironolactone (Aldactone)FDA LinkGeneric
03/03/2015 - "Of the 11,968 patients who died of sudden death while receiving spironolactone, we identified 328 whose death occurred within 14 days after antibiotic exposure. "
09/02/1999 - "This 30 percent reduction in the risk of death among patients in the spironolactone group was attributed to a lower risk of both death from progressive heart failure and sudden death from cardiac causes. "
12/01/1962 - "Hyperkalemia and sudden death during Spironolactone (Aldactone) therapy."
01/01/2000 - "Similarly, for spironolactone, the RALES study showed a reduced incidence of sudden death in cardiac failure, as its physiopathological modes of action suggested. "
05/01/2005 - "The RALES study has shown that spironolactone reduces the risk of morbidity and mortality both from progressive heart failure and sudden death in patients with NYHA class III or IV heart failure. "
|9.||Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
06/01/2001 - "The mechanism of ACE inhibitors benefits is multifactorial and includes prevention of progressive LV remodeling, prevention of sudden death and arrhythmogenicity and structural stability of the atherosclerotic process. "
06/01/2000 - "Sudden death and the electrophysiological effects of angiotensin-converting enzyme inhibitors."
01/01/2000 - "Sudden death: ACE inhibitors and beta-blockers."
05/22/1990 - "To date, however, ACE inhibitors have not been demonstrated to have a significant effect on the incidence of sudden death. "
08/01/1997 - "This influence of some ACE inhibitors on HRV may be beneficial in reducing the risk for sudden death in post-myocardial infarction patients."
|10.||Verapamil (Calan)FDA LinkGeneric
01/01/1996 - "These experiments tend to confirm the positive results recently obtained in man with verapamil in the prevention of postinfarction sudden death, provided that myocardial contractility is not too much adversely affected. "
02/01/1996 - "In contrast, and when taken together, the DAVIT-I and DAVIT-II studies with verapamil show significant reductions in sudden death, reinfarction and total mortality. "
02/01/1992 - "One of the interesting byproducts of that study was the possibility that verapamil prevented postinfarct sudden death, which implies a potential antiarrhythmic mechanism. "
08/01/2008 - "Verapamil, however, does not lower the risk of sudden death; therefore, an ICD implantation is advised. "
01/01/2001 - "This kind of VT had a high incidence of sudden death, so it was very important for physicians to identify and treat it promptly with long-term verapamil. "
|1.||Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
07/01/2010 - "This issue has acquired even greater relevance since implantable cardioverter-defibrillators have proved to be highly effective in preventing sudden death in high-risk subjects. "
04/01/2009 - "Therefore, identification of those patients at high risk of sudden death represents a major clinical problem and has become an even greater challenge since the implantable cardioverter-defibrillator (ICD) has proved to be highly effective in preventing sudden death in HCM. "
12/01/2007 - "Therefore, risk stratification for sudden death has a major role in the management of HCM and has acquired even greater relevance since the implantable cardioverter-defibrillator (ICD) has proved to be highly effective in preventing sudden death in this disease. "
03/11/1999 - "The implantable cardioverter defibrillator (ICD) is highly effective in the prevention of sudden death, but no mortality benefit in advanced CHF has yet been shown. "
03/01/1995 - "It has been shown that implantable cardioverter defibrillator (ICD) therapy has a low surgical mortality and is highly effective in the prevention of sudden death. "
03/01/2004 - "Implanted cardioverter defibrillator (ICD) is expensive but highly effective in preventing sudden death. "
05/01/2009 - "These observations also suggest that home automatic defibrillator strategies for sudden death prevention are unlikely to be effective in HCM."
10/01/2004 - "New evidence suggests that the implantable cardiac defibrillator (ICD) may be effective for primary prevention of sudden death. "
11/01/1995 - "Transvenous cardioverter defibrillators offer effective protection against sudden death. "
09/01/2012 - "Clinical studies of defibrillator/pacemaker therapy for primary prevention against sudden death in PAH patients are lacking."
|3.||Drug Therapy (Chemotherapy)
05/01/1996 - "Comparison of ICD outcome with that of drug therapy in three large retrospective studies and two small prospective randomized trials favors improved survival and sudden death prevention with device therapy. "
07/01/2012 - "We present a case of sudden death due to hemorrhagic expansion of the intra-atrial component of WT, immediately after commencement of chemotherapy, an uncommon incident."
02/01/2007 - "Contrary to the frequently repeated speculation that the risk stratification for sudden death and hence prophylactic placement of ICDs is reasonably accurate, there is little cost difference between pharmacotherapy and ICD treatment over the long term. "
10/01/2004 - "Drug therapy can reduce the incidence of sudden death in many subgroups of patients. "
03/01/2004 - "Using a standard cost-effectiveness threshold and plausible parameter ranges, it is unlikely that ICD is cost-effectiveness in preventing CHF sudden death relative to standard drug therapy."
06/01/1997 - "The results of this preliminary study suggest that removal of a patient from a heart transplant waiting list may represent a risk for sudden death, particularly in patients with elevated ventricular filling pressures, irrespective of otherwise favorable clinical status and exercise performance."
03/01/1996 - "Animal studies have shown reasonable cadaveric graft function up to several hours after sudden death by drug administration. "
09/01/2015 - "QT interval prolongation, a marker of risk for arrhythmias and sudden death, is highly prevalent among kidney transplant patients receiving different classes of immunosuppressive drugs."
02/01/2015 - "More than 750,000 people die of sudden death each year, and many are potential non-heart-beating donors (NHBDs) for lung transplant. "
01/01/2014 - "Sudden death in a patient with bone marrow transplant by a fungus among us."
|5.||Coronary Artery Bypass (Coronary Artery Bypass Surgery)
05/01/2013 - "Case 2: sudden death after coronary artery bypass surgery in a 49-year-old female, diabetic, dyslipidemic, hypertensive, obese patient."
12/01/2003 - "The problem of postoperative sudden death and the effect of age, gender and association of coronary artery bypass grafting were studied after implantation of a bioprosthetic valve in aortic position. "
09/04/1993 - "Incidences of reinfarction, sudden death, and coronary artery bypass grafting in one year. "
12/01/1985 - "We concluded that coronary artery bypass surgery is beneficial to certain survivors of prehospital sudden death. "
01/01/1985 - "There are many potential approaches to the prevention of reinfarction and sudden death, but the proof of benefit as yet is confined to the use of beta-adrenoceptor blocking drugs and coronary artery bypass surgery. "