Cytochalasins

11- to 14-membered macrocyclic lactones with a fused isoindolone. Members with INDOLES attached at the C10 position are called chaetoglobosins. They are produced by various fungi. Some members interact with ACTIN and inhibit CYTOKINESIS.

Networked: 40 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fondy, Thomas P: 3 articles (08/2015 - 11/2014)
2.	Trendowski, Matthew: 3 articles (08/2015 - 11/2014)
3.	Acquafondata, Christopher: 2 articles (08/2015 - 04/2015)
4.	Chen, Hongdan: 1 article (01/2022)
5.	Li, Qing: 1 article (01/2022)
6.	Li, Senlin: 1 article (01/2022)
7.	Lu, Yi: 1 article (01/2022)
8.	Tian, Cheng: 1 article (01/2022)
9.	Tong, Qingyi: 1 article (01/2022)
10.	Wang, Jia: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Due to the pivotal role of microfilament in cancer cells, targeting microfilaments with cytochalasins is considered a promising anticancer strategy. " 05/01/2015 - "New cytochalasins from medicinal macrofungus Crodyceps taii and their inhibitory activities against human cancer cells." 11/01/2014 - "Cytochalasins are mycogenic toxins derived from a variety of fungal sources that have shown promising in vitro efficacy in disrupting microfilaments and producing remarkable cell enlargement and multi-nucleation in cancer cells without producing enlargement and multi-nucleation in normal blood cells. " 05/01/2011 - "In vitro growth inhibitory effects of cytochalasins and derivatives in cancer cells." 02/01/1988 - "Photoaffinity labeling of plasma membrane receptors for cytochalasins in Ehrlich tumor cells."
2.	Sarcoma (Soft Tissue Sarcoma) 04/01/2023 - "The actin disruptive properties of all cytochalasins obtained in this study and of the previously reported cytochalasins RKS-1778 and phomopchalasin N were examined, and monitored by fluorescence microscopy using human osteo-sarcoma (U2-OS) cells. "
3.	Adenocarcinoma 12/16/2017 - "Therefore, in this study, we examined the effects of cytochalasins and structurally related compounds on cell survival and the regulation of autophagy in human lung A549 adenocarcinoma cells. "
4.	Leukemia 04/01/2015 - "In vivo, cytochalasins B and D substantially increased the life expectancy of mice challenged with P388/S and P388/ADR leukemias, and in some cases, produced long-term survival. " 04/01/2015 - "For in vivo characterization, cytochalasins B and D were administered intraperitoneally (i.p.) to Balb/c mice challenged with drug sensitive P388-S or multidrug resistant P388/ADR leukemias. " 01/01/1985 - "Effects of calmodulin antagonists and cytochalasins on proliferation and differentiation of human promyelocytic leukemia cell line HL-60." 01/01/1985 - "The effects of cytochalasins on the antigen-induced serotonin release from rat basophilic leukemia cells were investigated. " 01/01/1985 - "Effects of various cytochalasins on the IgE-mediated serotonin release from rat basophilic leukemia cells."
5.	Infections 01/01/1978 - "Nevertheless, a number of informative observations emerge which provide insight into specific aspects of the interaction of viruses with their host cells, and help us to understand the mode of action of cytochalasins on specific cellular functions: Cytochalasins may decrease or increase the competence of cells for infection by viruses. " 02/01/2002 - "Fluorescence staining of filamentous actin with a fluorescein-isothiocynate labelled mycotoxin, in the absence and presence of microfilament inhibitors cytochalasins B and D, and electron microscopy were used to investigate the role and fate of actin microfilaments during poliovirus infection, morphogenesis and release in an intestinal cell line, HRT-18. " 11/01/1994 - "Inhibition of infection of macrophages with Ehrlichia risticii by cytochalasins, monodansylcadaverine, and taxol."

Related Drugs and Biologics

1.	RKS 1778
2.	jasplakinolide
3.	Xanthones
4.	Terpenes (Terpenoids)
5.	Cytochalasin B
6.	Anthraquinones
7.	Alkaloids
8.	dihydrocytochalasin B
9.	Polyketides
10.	Cytostatic Agents

Related Therapies and Procedures

1.	Therapeutics